The frequency of combined IFITM3 haplotype involving the reference alleles of both rs12252 and rs34481144 is in line with COVID-19 standardized mortality ratio of ethnic groups in Englandrs12252 및 rs34481144의 참조 대립유전자를 포함하는 결합된 IFITM3 일배체형의 빈도는 영국의 인종 그룹의 COVID-19 표준화된 사망률과 일치합니다Computational Biology Published on 2020-11-122022-08-13 Journal: PeerJ [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project allele allele frequency alleles Analysis Asian association Bame black cellular Chinese Cohort collected Combination contribute correlation COVID-19 COVID-19 patient COVID-19 severity cytokine cytokine production Dengue Ebola England ethnic group Ethnic groups explain focus Frequency Genetic Haplotype HIV IFITM3 immune effector protein implicated implication Implications Influenza Invasion Latino mechanism Mortality mortality risk outcome past polymorphism Population protein 3 reference allele Regulation reported restriction rs12252 rs34481144 SARS-CoV-2 SARS-CoV-2 pandemic severity SNP Socioeconomic factor Socioeconomic Factors standardized mortality ratio Standardized Mortality Ratios subgroup subgroups suggested the disease transmembrane protein USA vaccination efficacy variant Viral viral replication viruses while White people with COVID-19 [DOI] 10.7717/peerj.10402 PMC 바로가기 [Article Type] Computational Biology
Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 PathogenesisReview Published on 2020-11-102022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acting acute lung injury acute respiratory distress acute respiratory syndrome alteration alterations Anti-inflammatory Antiviral ARDS autophagy baicalin cellular Clearing coagulation dysfunction Compound contribute cordycepin coronavirus Course COVID-19 Cytopathic effect Diseases Disseminated intravascular coagulation Effect endothelial feature Frame hallmark herbal compound Host host cell Immunoproteasome impairment in viral include Infection infections Inflammation inflammatory mediator Invasion kaempferol metabolic pathway MODS modulate multiple organ dysfunction neurological Novel coronavirus Occurrence outcome pandemic Pathogenesis pathway pharmacological Pneumonia polyphenol Potential quercetin Replication reported researcher respiratory viruses resveratrol SARS-CoV-2 SARS-COV-2 infection subcellular syndrome System systemic inflammation target Therapeutic approach therapy Transmission viral infection virion virus widespread [DOI] 10.3390/antiox9111105 PMC 바로가기 [Article Type] Review
Pirfenidone: A novel hypothetical treatment for COVID-19피르페니돈: COVID-19에 대한 새로운 가상 치료제Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] 신약개발, 유전자 메커니즘, 치료법, [키워드] ACE acute respiratory distress acute respiratory distress syndrome adverse effects angiotensin angiotensin converting enzyme Angiotensin converting enzyme receptor Apoptosis approved ARDS Cell COVID-19 COVID-19 patients cytokine Cytokine storm decrease distress downregulate expression fibrosis hypothetical idiopathic Idiopathic pulmonary fibrosis Inflammation inhibit Invasion IPF kill majority mechanism mechanism of action Mild mild to moderate mild to moderate disease moderate disease morbidity Mortality multiorgan failure oxidative stress pathophysiology Patient patients with COVID-19 Pirfenidone pneumocyte Pneumocytes PROTECT pulmonary pyridone receptor respiratory distress Respiratory distress syndrome syndrome Treatment treatment for COVID-19 treatment of COVID-19 patients [DOI] 10.1016/j.mehy.2020.110005 PMC 바로가기 [Article Type] Article
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer폐암에서 SARS-CoV-2 숙주 침입 유전자의 구조적 변이 및 발현 프로파일Article Published on 2020-11-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid analyses Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Anomaly Basigin binding can be used Cancer CD147 cleaving coronavirus correlation Correlation analysis COVID-19 effective enzyme Evidence evidence of expression expression levels expression profile Features furin Gene Expression Gene expression analysis Genes Genetic genomic groups healthy control Host hypothese hypotheses in silico in silico analysis Invasion Laboratory lung lung adenocarcinoma lung cancer mechanism Mutation pathogenic Patient recent residue respiratory SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly statistically survival survival analysis susceptibility target gene Target genes the RBD the SARS-CoV-2 therapy TMPRSS2 TMPRSS2 level today transmembrane serine protease transmembrane serine protease 2 Variation virus was determined was done [DOI] 10.1002/jmv.26107 PMC 바로가기 [Article Type] Article
COVID-19: Targeting Proteases in Viral Invasion and Host Immune ResponseMolecular Biosciences Published on 2020-10-092022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absence accelerated ACE2 administration antiviral drug approach Cathepsins caused chemokine clinical evidence coronavirus COVID-19 cytokine globe help Host Host immune response host immunity immune reaction immune response immune system in viral Infection infections inflammatory cell information Invasion involved knowledge MERS Perspective plasma Predictive promoted protease protease inhibitors Proteases proteolytic Research respiratory disorder response SARS-CoV-2 SARS-CoV-2 viral severity Spread suggested target protease targeting therapeutic response TMPRSS2 tracing vaccination virus [DOI] 10.3389/fmolb.2020.00215 PMC 바로가기 [Article Type] Molecular Biosciences
Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling AnalysisResearch Article Published on 2020-10-082022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein acute inflammatory response Angiotensin II angiotensin-converting enzyme inhibitor approach ARB binding blocker cardiovascular disease cardiovascular diseases Cell cell entry cell membrane chronic inflammation Chronic kidney disease coronavirus COVID-19 COVID-19 pandemic diabete diabetes disease disease severity dosage drug Effects enzyme epidemiological data epithelial cell Evidence exacerbated Factors heart failure help host cell host cells host’s immune response hypertension implication increase in induce Infection Inflammation inhibitor Invasion lack lethal disease Lungs mathematical medication medications Model modeling Mortality pandemic Pandemics pathogenesis of COVID-19 Patient physician predict RAS receptor renin-angiotensin system risk SARS- CoV-2 SARS-CoV SARS-CoV-2 severe COVID-19 subsequent suggested the spike protein therapy tissue damage tissues treated Treatment virus while [DOI] 10.1371/journal.pcbi.1008235 PMC 바로가기 [Article Type] Research Article
Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite말라리아 기생충의 숙주 세포 침입에 있어 Rhoptry 단백질 RhopH3의 인산화는 중요하다.Research Article Published on 2020-10-062024-08-11 Journal: mBio [Category] 말라리아, [키워드] host cell invasion Invasion malaria Phosphorylation protein phosphorylation Signaling [DOI] 10.1128/mBio.00166-20 PMC 바로가기 [Article Type] Research Article
Thromboprophylaxis with enoxaparin is associated with a lower death rate in patients hospitalized with SARS-CoV-2 infection. A cohort studyResearch paper Published on 2020-10-052022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] Adjusted analysis Admission analyzed caused Cohort cohort study collected coronavirus Coronavirus disease 2019 COVID-19 death rate Effect Endothelial cell enoxaparin evaluated Evidence finding foundation heparin hospital Hospital stay Hospitalization hypercoagulability in-hospital mortality Infection intensive care intensive care unit Invasion Logistic regression low molecular weight heparin Mortality multivariate nine overlap weight Patient patients hospitalized patients treated Poisson regression polymerase chain positive Proinflammatory cytokine randomized clinical trial Rate Ratio real time reduce reduced risk respiratory reverse transcription risk RT-PCR SARS-CoV-2 SARS-COV-2 infection Secondary outcomes Support Thromboprophylaxis Treatment was used [DOI] 10.1016/j.eclinm.2020.100562 PMC 바로가기 [Article Type] Research paper
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19Mini Review Published on 2020-10-052022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Central nervous system cerebrospinal fluid cerebrovascular diseases coronavirus coronavirus disease COVID-19 COVID-19 patient cranialis current Diagnosis Encephalitis Encephalopathy Evidence Features hematogenous Hemorrhagic highlight Invasion manifestation mechanisms Meningitis myopathies nervous system neurologic neurological Neurological involvement neurological manifestation Neurological symptom Neuropathogenesis pathogen patients positive recent Respiratory system reveal SARS-CoV-2 SARS-COV-2 infection Spread syndrome systemic symptom the disease Treatment Vaccines virus with COVID-19 [DOI] 10.1590/0037-8682-0477-2020 PMC 바로가기 [Article Type] Mini Review
Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patientsResearch article Published on 2020-10-012022-10-05 Journal: Heliyon [Category] 바이오마커, 유전자 메커니즘, [키워드] ACE2 ACE2 mRNA association AUC Biochemistry Biomarkers Clinical genetics confirmed case Contact COVID-19 COVID-19 patient COVID-19 patients DPP4 elevated EMILIN1 EMILIN2 expression expression level expression of SARS-CoV-2 functional genetics genomic Genomic biomarkers Host Host invasion genes Invasion knowledge less MMRN1 MMRN2 Molecular biology mRNA nasopharyngeal oropharyngeal swab overexpression patients positive profile raised SARS-CoV-2 SARS-CoV-2 infections severe COVID-19 severe COVID-19 patient severe symptom subject subjects the SARS-CoV-2 TMPRSS2 Virology with COVID-19 [DOI] 10.1016/j.heliyon.2020.e05143 [Article Type] Research article