A newly identified linear epitope on non-RBD region of SARS-CoV-2 spike protein improves the serological detection rate of COVID-19 patientsSARS-COV-2 스파이크 단백질의 비 RBD 영역에서 새로 확인 된 선형 에피토프는 COVID-19 환자의 혈청 학적 검출 속도를 향상시킵니다.Research Published on 2021-06-262022-09-01 Journal: BMC Microbiology [Category] MERS, 진단, 치료기술, [키워드] addition analyzed antibody Antigen asymptomatic infection asymptomatic infections asymptomatic patients B cell B cell linear epitopes Combination convalescent sera convalescent serum convenience correlation COVID-19 patient detect detection rate ELISA epitope epitope peptide Epitopes exhibited fast feasibility highest Humoral immunity identify IMPROVE Infectious disease Infectious diseases information lack linear linear epitopes lowest medium neutralizing antibody overlapping Patient peptide peptide-based peptides positive positive correlation positive rate Protein reaction rate reactivity reported Research Result S protein SARS-CoV-2 SARS-CoV-2 spike protein serological serological data serum samples significantly Spike protein subsequent supplementary material Support the S protein titre total patient total patients with COVID-19 [DOI] 10.1186/s12866-021-02241-y PMC 바로가기 [Article Type] Research
Acute kidney injury (AKI) in patients with Covid-19 infection is associated with ventilatory management with elevated positive end-expiratory pressure (PEEP)Observational Study Published on 2021-06-252022-10-04 Journal: Journal of Nephrology [Category] MERS, SARS, 임상, [키워드] 95% CI Abstract acute respiratory distress AKI AKI patients Analysis ARDS Clinical course COVID-19 CRRT Diagnostic Criteria elevated expiratory Factor higher risk ICU ICU patient ICU Patients incidence Infection intensive care KDIGO Kidney injury management median medium Mortality mortality rate occurred outcome outcomes Patient patients PEEP positive Positive end-expiratory pressure renal replacement therapy required Result retrospective severity significantly higher supplementary material syndrome ventilatory [DOI] 10.1007/s40620-021-01100-3 PMC 바로가기 [Article Type] Observational Study
Medication adherence in type 2 diabetes mellitus patients during Covid-19 pandemic: a cross-sectional study from the United Arab EmiratesResearch Article Published on 2021-06-252022-10-31 Journal: F1000Research [Category] Coronavirus, MERS, SARS, [키워드] 95% confidence interval adherence adherent average Care chronic disease Chronic diseases Compliance conducted coronavirus cross-sectional demonstrated diabete diabetic patient ENhance Factor Gender groups Health healthcare professionals identify knowledge medication medication adherence medium novel coronavirus disease pandemic Patient raise receive regimen regimens scale severity significantly the disease Treatment type 2 diabete Type 2 diabetes mellitus United Arab Emirate was used [DOI] 10.12688/f1000research.51729.2 PMC 바로가기 [Article Type] Research Article
Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-SpecificImmunology Published on 2021-06-232022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] activity age association average collected COVID-19 cross-sectional determinant disease exercise Factor female Gender Health IFN-γ immune function Immunity immunologically immunosenescence increased risk individuals interferon-γ investigated lack Logistic regression analysis Major medium men men and women Multiple natural NK cell NK cell activity objective Older pandemic physical Physical exercise Result risk risk factor Serum level significantly significantly lower subject subjects Vitamin D was measured women [DOI] 10.3389/fimmu.2021.594356 PMC 바로가기 [Article Type] Immunology
Rhamnolipids Nano-Micelles as a Potential Hand SanitizerArticle Published on 2021-06-222022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] active site adopted antibacterial agent antiviral agent antiviral treatments Bacteria caused characterized China Computational study COVID-19 demonstrated docking Docking studies hand Health hygiene in vitro Interaction investigated medium membrane permeability molecular multidrug resistant nano-micelles non-structural protein pandemic disease performed Perspective Potential problem produced Proteins Pseudomonas aeruginosa Rhamnolipid rhamnolipids SARS-CoV-2 selected shown silico study social distancing suggested the SARS-CoV-2 utility virus transmission [DOI] 10.3390/antibiotics10070751 PMC 바로가기 [Article Type] Article
Studying the Effect of Taking Statins before Infection in the Severity Reduction of COVID-19 with Machine LearningResearch Article Published on 2021-06-192022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Accuracy Algorithm Analysis angiotensin-converting enzyme-2 atorvastatin average Classifier Clinical features COVID-19 COVID-19 infection COVID-19 patient COVID-19 severity COVID-19 virus Critical death diagnose diastolic pressure Effect evaluate examined FIVE help Illness severity include indicated Iran machine learning machine learning approach medium Mild Other oxygen saturation participant Patient positive predict Research respiratory rate Result Rosuvastatin severity Simvastatin statin Support SVM Taking total patients Treatment [DOI] 10.1155/2021/9995073 PMC 바로가기 [Article Type] Research Article
Evaluation of a High-Definition PCR Assay for the Detection of SARS-CoV-2 in Extracted and Nonextracted Respiratory Specimens Collected in Various Transport Media다양한 운송 매체에서 수집된 추출 및 비추출 호흡기 표본에서 SARS-CoV-2 검출을 위한 고화질 PCR 분석 평가Article Published on 2021-06-172022-09-11 Journal: American journal of clinical pathology [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 benefit Chain Reaction collected conducted coronavirus Cycle threshold values demonstrated detection Extracted extraction extraction-free method Extraction-free PCR High-definition PCR increase in individual Limits of detection medium nucleic acid nucleic acid extraction PCR polymerase chain polymerase chain reaction positive protocol reagent reagents Real-time PCR reduced remained replicate respiratory RT-PCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimen specimens swab specimen symptomatic and asymptomatic Transport Transport media transport medium upper respiratory [DOI] 10.1093/ajcp/aqab060 PMC 바로가기 [Article Type] Article
Sensitive detection and quantification of SARS-CoV-2 in saliva타액에서 SARS-COV-2의 민감한 검출 및 정량화Article Published on 2021-06-142022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] authorization Biological techniques Biomarkers collected Community Comprehensive COVID-19 detect digital PCR Emergency EUA evade evaluate hospital Hospitalized infected cases Infectious diseases Inpatient Laboratory large cohort limitation medium nasal swab nasal swabs nucleic acids Outpatient Patient patients performed positive quantification Real-time reverse transcription PCR reliability reverse transcription PCR RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid sensitive sensitivity specimen tested Viral Viral load viral loads [DOI] 10.1038/s41598-021-91835-7 PMC 바로가기 [Article Type] Article
Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assaysRT-PCR 진단 분석에 적합한 구아니듐 기반 운송 배지를 사용하여 타액에서 SARS-Cov-2 바이러스의 불 활성화Research Article Published on 2021-06-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] 1:1 abrogated buffer Cell culture chain Chain Reaction clinical sample clinical samples condition conditions Copan COVID-19 CPE Cytopathic effect detect detectable diagnostic Dilution downstream evaluated expand guanidinium hazard inactivated inactivation Incubation infectious limit of detection log media medium minute passages positive processing reaction remained respiratory respiratory sample Result room temperature RT-PCR Saliva sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 virus stability temperature tested Transport upper VeroE6 cell VeroE6 cells Viral Viral RNA virus [DOI] 10.1371/journal.pone.0252687 PMC 바로가기 [Article Type] Research Article
Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion나이지리아 인 코호트로부터 혈장 샘플에서 검출 된 저수준 SARS-COV-2 RNA : 혈액 수혈에 대한 시사점Research Article Published on 2021-06-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection average age BGI Blood blood plasma blood sample Blood samples Blood Transfusion Chain Reaction Cohort Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Ct value detection diagnose diagnostic EDTA Effects False negative false negatives False positive fluorescent global pandemic implication in viral individual male median medium MINI nasal swab nasopharyngeal Oropharyngeal PCR plasma plasma sample polymerase chain polymerase chain reaction positive Qiagen real time Real-time PCR recorded respiratory RNA RT-PCR RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 test SARS-CoV-2 viral RNA Sensitivity and specificity severe acute respiratory syndrome Coronavirus specificity sputum study participant Study participants Swab swab sample tested Transport transport medium triggered venepuncture Viral Viral RNA viral RNA Mini Kit VTM was done was obtained [DOI] 10.1371/journal.pone.0252611 PMC 바로가기 [Article Type] Research Article