Porcine Epidemic Diarrhea Virus RNA Present in Commercial Spray-Dried Porcine Plasma Is Not Infectious to Naïve PigsResearch Article Published on 2014-08-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Administered Alter antibody assigned Canada Cell culture component condition determine disease course epidemic diarrhea evaluate Evidence FIVE group indicate log naïve North America PEDV pig plasma positive post inoculation present raised Randomly remained RNA seroconvert seroconverted significantly Spread Transmission treatment groups virus [DOI] 10.1371/journal.pone.0104766 PMC 바로가기 [Article Type] Research Article
An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of conceptResearch Article Published on 2014-08-052022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] affected bioassay Clinical sign clinically Complete controls diarrhea Epidemic epidemic diarrhea experiment Feed in vivo Infection initial Initially intestinal lesion naïve negative negative control no evidence of PCR PEDV Porcine positive Result risk risk factor RNA Spread Support Transmission viral shedding virus virus infection vomiting was tested were used [DOI] 10.1186/s12917-014-0176-9 PMC 바로가기 [Article Type] Research Article
Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirusResearch Published on 2014-05-062022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated acute respiratory syndrome ADE Analysis Anti-viral antibodies antibody Antibody-dependent enhancement binding Cell cells chimeric competent consequence coronavirus cytoplasmic dependent on downstream elicited ENhance evaluate Fcγ receptor FcγR Fluorescence full-length Health heat-inactivated human coronavirus human macrophage human macrophages human monocyte-derived macrophage IgGs immune Immune cell immune complex Infection Infection route information Lentiviral particle Macrophage Microscopy molecular mechanism naïve observation Occurrence Pathogens performed polymerase chain Pseudotypes Public Quantitative receptor receptors Replication reported response Result risk RT-PCR SARS-CoV SARS-CoV vaccine serum shown Signaling signaling domain signaling pathway spike Support susceptibility transcriptase Trimers vaccination virus [DOI] 10.1186/1743-422X-11-82 PMC 바로가기 [Article Type] Research
The Adjuvanticity of an O. volvulus -Derived r Ov -ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human PrimatesResearch Article Published on 2012-05-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation adjuvant adjuvanticity administration anti-RBD antibody Antibody Response antigens bystander Course DC different Effectiveness Efficacy element first vaccination functional host response IFN-γ IgG2a IL-2 IL-6 immunized induce Influenza virus maturation mice naïve NHPs non-human primate not affect Onchocerca volvulus primate promote promoted Protective protective immune response Protein provided RBD reported retained SARS-CoV spike protein sera subsequent Th1 Th1 cytokines Th2 response the receptor-binding domain titre TNF-α upregulated utility vaccination Vaccine vaccine antigen virus strains was used [DOI] 10.1371/journal.pone.0037019 PMC 바로가기 [Article Type] Research Article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article