SARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular responseSARS-CoV-2 mRNA 백신 BNT162b2는 일관된 교차 변형 체액 및 세포 반응을 유발합니다Observational Study Published on 2021-12-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 임상, 진단, 치료기술, [키워드] administration all subject Alpha antibody Antibody Response Antibody titre B.1 B.1.1.7 B.1.351 B.1.525 B.1.617.2 Beta BNT162b2 BNT162b2 vaccine cellular response chemiluminescence immunoassay CLIA CLIA assay CLIA assays Cohort correlation Definition Delta dose Efficacy elicited Eta evaluated Gamma HCW HCWs Health care Health care worker humoral Humoral response immune evasion immune response immunoassays in vitro mRNA vaccine Neutralization assay Neutralizing activity NTA observé P.1 pandemic Protective protective neutralizing antibody provided quantity reliability robust SARS-CoV-2 SARS-CoV-2 bnt162b2 mRNA vaccine SARS-CoV-2 pandemic SARS-CoV-2 variants SARS-CoV-2 variants of concern strain Strains T-cell mediated respone T-cell Response tested the SARS-CoV-2 Trigger vaccinal vaccination variants of concern VoC [DOI] 10.1080/22221751.2021.2004866 PMC 바로가기 [Article Type] Observational Study
Serological anti-SARS-CoV-2 neutralizing antibodies association to live virus neutralizing test titers in COVID-19 paucisymptomatic/symptomatic patients and vaccinated subjects혈청학적 항-SARS-CoV-2 중화 항체와 COVID-19 무증상/증상 환자 및 백신 접종 대상에서 살아있는 바이러스 중화 시험 역가와의 연관성Article Published on 2021-12-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies Anti-spike antibody association automated Concentration correlation COVID-19 cut-off cut-off value detect functional group groups identify immunoassay immunoassays Live virus Live VNT median NAb neutralization test neutralization titer neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Patient PROTECT Protective reference test risk of infection ROC Curve SARS-CoV-2 SARS-CoV-2 neutralizing antibodies second dose Serological assay Serological immunoassay. Serum level Strains subject subjects symptomatic symptomatic patient Symptomatic patients the SARS-CoV-2 vaccinated individuals variant Viral viral infection virus virus infection virus neutralization assays virus neutralization test VNT [DOI] 10.1016/j.intimp.2021.108215 PMC 바로가기 [Article Type] Article
Limited Impact of Delta Variant’s Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population라틴계 집단에서 자연 감염 또는 COVID-19 백신에 의해 부여 된 중화의 효과에 대한 델타 변형 돌연변이가 제한된 영향Comparative Study Published on 2021-11-302022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] breadth COVID-19 COVID-19 vaccine Delta delta variant doses Epsilon Evidence Impact impacted individual individuals induce Latino Limited natural neutralization neutralization capacity Neutralizing activity Neutralizing antibodies neutralizing antibody Population protection public health system public health systems SARS-CoV-2 SARS-CoV-2 pandemic serology tested Transmissibility vaccinated individual vaccine dose variant variants virulence [DOI] 10.3390/v13122405 PMC 바로가기 [Article Type] Comparative Study
Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individualsBNT162B2- 암시 처리 된 개체에서 부작용 및 면역 동역학과의 중화/SARS-COV-2-S1- 결합 항체 반응의 상관 관계Article Published on 2021-11-242022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] adverse effect adverse effects Antibody Response average B.1.351 blocked BNT162b2 determinant dose doses effective enrolled examined feature greater healthy individual IgG levels immune immune response Immunity individual individuals inverse correlation Japan measure men moderate mRNA vaccine mRNA vaccines neutralization Neutralizing activity no correlation Pain Participants potency Prospective Study Protective RNA vaccines SARS-CoV-2 sera Significant symptomatic infection Vaccine variants variants of concern viral infection virions was determined while women [DOI] 10.1038/s41598-021-01930-y PMC 바로가기 [Article Type] Article
Application of SARS-CoV-2 Serology to Address Public Health Priorities공중 보건 우선 순위를 해결하기 위한 SARS-CoV-2 혈청학의 적용Public Health Published on 2021-11-232022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] address Analysis Antibody Response application applied assays binding Clinical research complex COVID-19 cases Critical detect ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibited healthcare highlight IgG Immunity individual level Mild multiplex Neutralizing activity non-COVID-19 case performed population surveillance positive correlation priority Public public health R 2 RBD RBD ELISA Receptor-binding domain Research robust ROC Curve RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG serologic assay serology Surveillance the receptor-binding domain utility vaccination [DOI] 10.3389/fpubh.2021.744535 PMC 바로가기 [Article Type] Public Health
Antibody cocktail effective against variants of SARS-CoV-2SARS-CoV-2 변종에 효과적인 항체 칵테일Research Published on 2021-11-232022-09-10 Journal: Journal of Biomedical Science [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed antibody antibody cocktail B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 Beta binding ability binding activity Brazil caused circulating SARS-CoV-2 variant cocktail Cocktail therapy Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta effective Efficacy Epsilon evaluate exhibited Gamma hamsters high mutation rate India Iota mutation rate neutralization Neutralizing neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody new SARS-CoV-2 New York Plaque assay plaque assays Post-infection PRNT Prophylactic pseudovirus pseudoviruses Receptor-binding domain (RBD) respiratory Result retained RNA virus SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) South Africa Spike protein Spike proteins tested the SARS-CoV-2 the spike protein therapeutic effect Treatment United Kingdom Vaccine variant variants variants of SARS-CoV-2 [DOI] 10.1186/s12929-021-00777-9 PMC 바로가기 [Article Type] Research
MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 VariantsSARS-CoV-2 변이체에 대한 매우 강력한 단일클론 중화 항체로서의 MG1141AImmunology Published on 2021-11-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha antibody Antibody therapeutics Beta Brazil contribute coronavirus coronavirus disease disease outbreak effective Efficiency exhibited Fc-mediated functions Hospitalization humanized monoclonal antibody immunization infections live viruses MG1141A Mild moderate infections monoclonal antibody Mutation neutralize Neutralizing Neutralizing activity outbreak Patient potent Protein Receptor-binding domain reduce reducing respiratory retained SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 neutralizing antibody severe acute respiratory syndrome Coronavirus South Africa Spike protein the receptor-binding domain the spike protein Therapeutic approach treat variants of SARS-CoV-2 virus [DOI] 10.3389/fimmu.2021.778829 PMC 바로가기 [Article Type] Immunology
Safety and Immunogenicity Analysis of a Newcastle Disease Virus (NDV-HXP-S) Expressing the Spike Protein of SARS-CoV-2 in Sprague Dawley RatsSprague Dawley 쥐에서 SARS-CoV-2의 스파이크 단백질을 발현하는 뉴캐슬병 바이러스(NDV-HXP-S)의 안전성 및 면역원성 분석Immunology Published on 2021-11-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (Alpha) (Beta acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Alpha animal model Antibody titer Antibody titers approach B.1.1.7 B.1.351 B.1.617.2 Beta boost Brazil clinical clinical testing coronavirus country COVID-19 elicited expand expressing followed by Histopathology Immunity immunogenicity immunogenicity analysis induce intramuscularly intranasally Local mucosal Neutralizing activity newcastle disease virus performed Post-mortem pre-fusion RAT rat model reactogenicity regimen Region respiratory robust Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine second serum antibodies serum antibody severe acute respiratory syndrome Coronavirus Spike protein Spread systemic reactions tested the Spike the spike protein the United State the vaccine Toxicity United States vaccination vaccination rate Vaccine vaccine administration variants of concern VOCs were assessed wild type [DOI] 10.3389/fimmu.2021.791764 PMC 바로가기 [Article Type] Immunology
Production and Characterization of Nucleocapsid and RBD Cocktail Antigens of SARS-CoV-2 in Nicotiana benthamiana Plant as a Vaccine Candidate against COVID-19Article Published on 2021-11-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antibody Antigen antigens Antiviral candidate characterization co-expressed co-expression cocktail COVID-19 COVID-19 pandemic COVID-19 vaccine demonstrated domain drugs effective elicited global public health high risk immunization immunized mAb mice monoclonal N protein Neutralizing activity Nicotiana benthamiana nucleocapsid nucleocapsid protein plant polyclonal antibody produced Production Protein purification purified RBD RBD of SARS-CoV-2 RBD-specific antibody reactivity Safe SARS-CoV-2 SARS-CoV-2 coronavirus strain Support therapeutic transient expression system vaccine candidate Vaccines variant virus [DOI] 10.3390/vaccines9111337 PMC 바로가기 [Article Type] Article
Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study감염 후 10 개월에 첫 파동 감염된 개체에서 SARS-COV-2에 대한 항체 중화 항체의 지속성 : UNIRSA 코호트 연구Brief Report Published on 2021-11-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] Anti-spike antibody binding domain Bio-Techne Cohort collected COVID-19 Critical elicited first positive First wave fraction geometric geometric mean humoral IgG antibody IgG titers immune response individual Infection Italy longitudinal longitudinal analysis Mild Mild disease Month natural infection neutralization titer Neutralizing activity neutralizing antibody neutralizing humoral response pandemic PCR test performed pseudotype public health R&D Systems RBD Re-infection SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity seroconverted seronegative Seropositivity serum sample subject subjects USA Vaccine development was tested Wave were infected [DOI] 10.3390/v13112270 PMC 바로가기 [Article Type] Brief Report