Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity흰 족제비 모델에서 SARS-CoV-2 감염에 대한 용량 의존적 반응 및 보호 면역의 증거Article Published on 2021-01-042022-09-12 Journal: Nature Communications [Category] 변종, 진단, [키워드] animal model bronchopneumonia candidate vaccine clinical disease COVID-19 dosage dose dosed Endpoint endpoints Evidence ferret ferrets groups High dose induce Infection infection with SARS-CoV-2 intranasally low dose lung Lung pathology medium Mild mild infection pathology pfu progression protective immunity Replication respiratory SARS-CoV-2 SARS-COV-2 infection Therapeutics upper respiratory tract URT UTR Viral Viral RNA Viral RNA shedding viral shedding virus Virus shedding [DOI] 10.1038/s41467-020-20439-y PMC 바로가기 [Article Type] Article
Antibody response to SARS-CoV-2 infection in humans: A systematic review인간의 SARS-CoV-2 감염에 대한 항체 반응: 체계적인 검토Research Article Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] Medicine and Health Sciences, MERS, SARS, 진단, 치료기술, [키워드] Abstract acute phase acute respiratory syndrome antibody Antibody Response Antibody responses appraisal article assessment Asymptomatic asymptomatic infection carried characterising Characteristics clinically cohort study Comprehensive Consensus convalescent plasma Coronaviridae COVID-19 declining demographic characteristics described detectable determinant disease disease control disease onset disease severity eight evaluated Evidence evidenced finding FIVE heterogeneity hospitalised patient Hospitalised patients humoral immune response IgG IgM Immunity implication in vivo initial less limitation literature methodological limitations Mild MOST Neutralising Antibodies neutralising antibody neutralising antibody titre outcome pathogen peaked peaking post-symptom onset Progress protective immunity Public Quality reported researchers respiratory Result SARS-CoV-2 SARS-COV-2 infection screened Serological assay Seven Severe acute respiratory syndrome Specific statistical analysis Study participants symptom onset synthesised systematic review the antibody response the patient Therapeutics title titre titres Vaccines [DOI] 10.1371/journal.pone.0244126 PMC 바로가기 [Article Type] Research Article
Functional antibodies as immunological endpoints to evaluate protective immunity against Shigellaarticle Published on 2020-12-312024-09-01 Journal: Human vaccines & immunotherapeutics [Category] 세균성이질, [키워드] correlates of protection functional antibodies protective immunity Shigella threshold of protection trials for developing countries vaccinology [Article Type] article
HCoV-NL63 and SARS-CoV-2 Share Recognized Epitopes by the Humoral Response in Sera of People Collected Pre- and during CoV-2 PandemicArticle Published on 2020-12-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome addition antibodies antibody Antibody Response Asymptomatic children competitive ELISA coronavirus COVID-19 cohort cross Cross reactivity cross-reactivity definitive diagnosis ELISA epitope Epitopes evaluated HCoV-NL63 Human incidence mild symptoms NL63 Older Patient patients peptides plasma sample protective immunity reduce reported response S protein epitope SARS-CoV-2 SARS-CoV-2 epitope severity significantly higher specific antibody the disease the timing was performed [DOI] 10.3390/microorganisms8121993 PMC 바로가기 [Article Type] Article
Accelerator or Brake: Immune Regulators in Malaria가속기 또는 브레이크: 말라리아의 면역 조절자Article Published on 2020-12-102024-08-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] immune regulators immune responses malaria protective immunity signaling mechanisms type I interferon [DOI] 10.3389/fcimb.2020.610121 PMC 바로가기
Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)Immunology Published on 2020-12-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response Course COVID-19 Critical Evidence global pandemic Human immune system immune response Immunity immunogenicity immunological characteristics implication Infection knowledge long-lasting memory response Novel coronavirus outbreak pandemic Protective protective immunity question raising Reinfection reported SARS-CoV SARS-CoV-2 Sterilising Strategy the disease Vaccine Vaccine development virus Wuhan, China [DOI] 10.3389/fimmu.2020.571481 PMC 바로가기 [Article Type] Immunology
A Prospective Study on Rapidly Declining SARS‐CoV‐2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?Allergy/Immunology Published on 2020-12-022022-10-31 Journal: Cureus [Category] COVID-19, [키워드] antibody Antibody Response B-cell Can COVID-19 COVID-19 infection Critical eight generate IgG IgG antibodies IgG antibody immune response Immunity immunoassay Immunoglobulin Immunoglobulin G individual initial Month neutralizing antibody non-randomized participated positive positive individual Potential Prospective Prospective clinical trial Protective protective antibodies protective immunity quantitative assay Randomly reported Result retained RT-PCR SARS‐CoV‐2 selected single-arm subjects sustained Symptom Testing Trial Vaccine [DOI] 10.7759/cureus.11845 PMC 바로가기 [Article Type] Allergy/Immunology
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate Research Published on 2020-12-012022-10-05 Journal: Nature [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome animal models Antigen candidate vaccine Cellular immune response coronavirus coronavirus disease COVID-19 cynomolgus macaque Efficacy Express Fever hamster immune response Immunity induce infection with SARS-CoV-2 Lung disease macaques Mesocricetus mice Mus pandemic prefusion Prevent protective immunity Safe safety profile SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine single dose T helper the SARS-CoV-2 triggered Vaccine vaccine platform Vaccines virus [DOI] 10.1038/s41586-020-3035-9 [Article Type] Research
Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platformArticle Published on 2020-11-302022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] Antigen Cancer caused cellular immune responses Coronavirus-2 develop development DNA expressing generate global pandemic humoral immunized immunodominant implicated Infectious disease Live attenuated vaccines mice Neutralizing antibodies nucleocapsid antigen nucleocapsid antigens platform poxvirus protective immunity robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine stimulate unique Vaccine vaccine candidate vaccine platform vaccinia vector viral infection [DOI] 10.1038/s41467-020-19819-1 PMC 바로가기 [Article Type] Article
Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico AnalysisResearch Article Published on 2020-11-192022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome Analysis association candidate vaccine caused cholera complex conducted coronavirus COVID-19 COVID-19 disease develop EAAAK linker epitope Epitopes feasible flexible globe GPGPG linkers Health HLA hydrogen bonds in vitro experiment in vivo Interaction molecular docking analysis multiepitope vaccine N-terminus positive protective immunity Safe SARS-CoV-2 sequence spike glycoprotein stability subunit suggested Support the Spike the vaccine toxin Vaccine was performed [DOI] 10.1155/2020/8893483 PMC 바로가기 [Article Type] Research Article