Evaluation of electropolymerized molecularly imprinted polymers (E-MIPs) on disposable electrodes for detection of SARS-CoV-2 in saliva타액에서 SARS-CoV-2 검출을 위한 일회용 전극의 전기중합 분자 각인 폴리머(E-MIP) 평가Article Published on 2022-05-082022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence biosensor capture COVID-19 COVID-19 negative crosslinked demonstrated Electrochemical impedance spectroscopy Electrochemical polymerization evaluated functional isothermal LAMP limit of detection log Molecularly imprinted polymers monoclonal antibody monomer N,N'-methylenebisacrylamide National Health Service nine nucleic acid nucleic acid amplification Other respiratory viruses Patient PCA Polymer positive positive sample Principal component principal component analysis pseudoparticle respiratory respiratory viruses Saliva saliva samples SARS-CoV-2 selective selectivity specificity threshold threshold value transfer Treatment UK National Health Service virus [DOI] 10.1016/j.aca.2022.339777 PMC 바로가기 [Article Type] Article
Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2SARS-CoV-2에 대한 RNA 추출 없는 타액 기반 분자 분석의 종합적인 분석 및 임상 평가Article Published on 2022-05-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition analytical sensitivity clinical evaluation Comprehensive described diagnostic false-negative gold gold standard house individual individuals invasive Laboratory medical staff molecular molecular analysis participated PCR protocol provided repeated RNA RNA extraction RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 testing sensitivity shown specificity Standard Swab swabs testing protocols [DOI] 10.1371/journal.pone.0268082 PMC 바로가기 [Article Type] Article
Multiplatform Assessment of Saliva for SARS-CoV-2 Molecular Detection in Symptomatic Healthcare Personnel and Patients Presenting to the Emergency Department증상이 있는 의료 종사자 및 응급실에 내원하는 환자에서 SARS-CoV-2 분자 검출을 위한 타액의 다중 플랫폼 평가Article Published on 2022-05-042022-09-11 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assessment center clinical symptom Clinical symptoms collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cycle threshold value Department detection DiaSorin Direct Emergency emergency department enrolled evaluated healthcare personnel knowledge Lyra molecular Molecular assay molecular assays nasopharyngeal NP swab NP swabs Patient positive presenting relative sensitivity respiratory Saliva saliva sample saliva samples saliva specimen saliva specimens SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimen subset swabs symptomatic These data university Variability [DOI] 10.1093/jalm/jfab115 PMC 바로가기 [Article Type] Article
Impact of Oral Rinsing with Octenidine Based Solution on SARS-CoV-2 Loads in Saliva of Infected Patients an Exploratory Study옥테니딘 기반 용액으로 구강 헹굼이 감염된 환자의 타액에서 SARS-CoV-2 부하에 미치는 영향 탐색적 연구Article Published on 2022-05-042022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] All study participants baseline level baseline levels Cell culture clinical collected COVID-19 patient COVID-19 patients demonstrated eight FIVE highlight Impact infectious Infectivity investigated load material mouth octenidine Octenisept oral oral rinsing. participant phenoxyethanol qPCR quantified reduction returned rinsing RNA RNA load RT-qPCR Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA solution Study participants the SARS-CoV-2 undetectable virus isolation was performed [DOI] 10.3390/ijerph19095582 PMC 바로가기 [Article Type] Article
Transmission and Infectious SARS-CoV-2 Shedding Kinetics in Vaccinated and Unvaccinated Individuals예방 접종 및 예방 접종을 받지 않은 개인의 전염 및 전염성 SARS-CoV-2 배출 역학Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age attack rate Breakthrough infection breakthrough infections Care Caregivers Cell culture Chain Reaction cohort study Community comparable contribute COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccinations Culture delta variant diagnosed with COVID-19 evaluate Evidence female genomic genomic RNA groups Health care health care workers hospital Hospitalization individual individuals Infection initial Inpatients Kinetics less median median age Mild outcome Patient performed polymerase chain polymerase chain reaction residence Saliva saliva samples SARS-CoV-2 secondary secondary attack rate secondary transmission shedding significantly South Korea Spread symptom onset Transmission vaccinated individual Vaccination Status Viral load viral shedding virus virus culture was measured with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.13606 PMC 바로가기 [Article Type] Article
A randomized, controlled, feasibility study of RD-X19 in subjects with mild-to-moderate COVID-19 in the outpatient setting외래 환자 환경에서 경증에서 중등도의 COVID-19가 있는 피험자를 대상으로 한 RD-X19의 무작위, 대조, 타당성 연구Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adverse events Alpha assessment assessments baseline benefit Beta clinical assessment clinical assessments Clinical outcome coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines Device dose doses double-blind enrolled epithelial Epithelial Tissue expression feasibility Feasibility study greater IL-1α IL-1β immune in vitro internal Local Local application log log rank test Measures median time Mild mild to moderate Mild-to-moderate moderate Moderate COVID-19 oral cavity oropharynx outcome measure Outpatient outpatients positive Randomized reaction reduction Replication Saliva SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 strain Severe acute respiratory syndrome shown Signs and symptoms subject sustained Symptom tested the mean tissue tissues treated Treatment variants Viral load visible light [DOI] 10.1111/cts.13249 PMC 바로가기 [Article Type] Randomized Controlled Trial
Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousnessArticle Published on 2022-05-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute infection B.1.1.7 circulating clearance clearance rate contribute Daily explained Genome heterogeneity High-resolution Human in viral individual individual-level heterogeneity Infection Infectious virus nasal swabs peaked reveal Saliva SARS-COV-2 infection SARS-CoV-2 replication Significant tissue Transmissibility variant Variation Viral load Viral RNA shedding virus [DOI] 10.1038/s41564-022-01105-z PMC 바로가기
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection전신 및 점막 IgA 반응은 SARS-CoV-2 mRNA 백신 접종에 대한 반응으로 다양하게 유도되며 후속 감염에 대한 보호와 관련이 있습니다.Article Published on 2022-05-012022-09-11 Journal: Mucosal Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] anti-SARS-CoV-2 Anti-spike booster Breakthrough infection breakthrough infections collected comparable COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines dose elicit Examining exhibited groups IgA IgA response IgG IgG level IgG levels in some infect infected with SARS-CoV-2 Infection Kinetics kinetics of antibody Local mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccination mucosal IgA response oral cavity participant Participants persist positive preventing infection prospective cohort provoke RBD RBD IgA receiving reduce respiratory Saliva SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose serum subsequent systemic These data Transmission upper respiratory tract utility [DOI] 10.1038/s41385-022-00511-0 PMC 바로가기 [Article Type] Article
Establishment of an in-house real-time RT-PCR assay for the detection of severe acute respiratory syndrome coronavirus 2 using the first World Health Organization international standard in a resource-limited country자원이 제한된 국가에서 최초의 세계보건기구 국제표준을 이용한 중증급성호흡기증후군 코로나바이러스 2 검출을 위한 사내 실시간 RT-PCR 분석법 구축Article Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome caused Clinical performance clinical sample clinical samples conserved coronavirus correlation country COVID-19 COVID-19 pandemic Critical E gene evaluated house International international standard limit of detection molecular molecular assays multiplex N gene Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal swabs NIBSC Patient PCR assay positive Primers probe probes public health real-time RT-PCR reference standard Region RT-PCR assay Saliva SARS-CoV-2 specimen Standard Target genes WHO World Health Organization [DOI] 10.1002/jcla.24355 PMC 바로가기 [Article Type] Article
Is saliva collected passively without forceful coughing sensitive to detect SARS-CoV-2 in ambulatory cases? A systematic review보행 시 SARS-CoV-2 검출에 민감한 기침을 하지 않고 수동적으로 침을 채취합니까? 체계적인 검토Review Published on 2022-05-012022-09-11 Journal: Oral surgery, oral medicine, oral pathology and or [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence Asymptomatic Chain Reaction Cohort collected conducted coughing cross-sectional detect inclusion criteria lack limitation Lower mildly symptomatic patient mildly symptomatic patients nasopharyngeal sample Nasopharyngeal samples nasopharyngeal swabs polymerase chain polymerase chain reaction Previous studies Prospective reported reverse transcription reverse transcription polymerase chain reaction RT-PCR Saliva sample collection SARS-CoV-2 SARS-CoV-2 detection sensitivity severity stages supervision symptomatic systematic review the disease Viral load was performed [DOI] 10.1016/j.oooo.2022.01.002 PMC 바로가기 [Article Type] Review