Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies불활성화 백신의 동종 또는 이종 부스터는 중화 항체로부터 SARS-CoV-2 오미크론 변이체 탈출을 감소시킵니다.Coronaviruses Published on 2022-02-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accumulated addition antibodies Antibody titer B.1.1.529 BBIBP-CorV booster booster vaccination convalescent dose eight epitope Epitopes Heterologous homologous homologous or heterologous identified variant inactivated Inactivated vaccine individual less mAb mAbs monoclonal antibodies monoclonal antibody neutralization neutralization titer neutralization titers Neutralizing neutralizing antibody Neutralizing antibody titer NTD omicron Omicron variant protein subunit vaccine pseudovirus raising RBD reduce reduction SARS-CoV-2 SARS-CoV-2 variants sera Seven significantly increased spike mutations Subunit vaccine tested the vaccine therapeutic therapeutic antibodies transmission of SARS-CoV-2 urgency Vaccine variant Viral viral variant VOCs ZF2001 [DOI] 10.1080/22221751.2022.2030200 PMC 바로가기 [Article Type] Coronaviruses
Evaluation of Two Rapid Lateral Flow Tests and Two Surrogate ELISAs for the Detection of SARS-CoV-2 Specific Neutralizing AntibodiesMedicine Published on 2022-02-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] collected convalescent patient COVID-19 detection diagnostics ELISA Euroimmun evaluated Flow highest Lateral lateral flow lateral flow assay lowest negative control sample neutralization Neutralizing antibodies Rapid SARS-CoV-2 sensitivity sera serological significant difference Specific specific neutralizing antibody specificity surrogate Test tested vaccinated individual vaccinated individuals vaccination [DOI] 10.3389/fmed.2022.820151 PMC 바로가기 [Article Type] Medicine
High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 9.0고급 SARS-COV-2 NucleoCapsid 포함 물체 용량을위한 온화한 상태를 사용한 폴딩 : pH 9.0에서 고압의 적용Research Article Published on 2022-02-032022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] aggregate alkaline antibody Antibody binding Antigen application association Bacterial best binding condition conserved Coronaviruses Culture culture media described Diagnosis dialysis Disulfide E . coli effective electrostatic repulsion ELISA expressed for inclusion fragment of Host hydrophobic Inclusion inclusion bodies ionic interaction kDa knowledge media Mild motif non-specific Patient presenting promote promoted Protein purification purity SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid sera solubilization tertiary structure Viral Viral protein western blotting yield [DOI] 10.1371/journal.pone.0262591 PMC 바로가기 [Article Type] Research Article
Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies단순하고 민감한 특정 자체 샘플링 분석은 혈청-홍보 및 산후 연구에서 SARS-COV-2 항체 신호를 보호합니다.Article Published on 2022-02-032022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] 95% CI 95%CI Acute inflammation Analysis antibody Blood capture collected comparable correlation damaged DBS eluate DBS eluates diagnostic diagnostic sensitivity displaying ELISA ELISAs facilitate feasibility IgG and IgM IgM antibody individual Laboratory limits Limits of detection population level Post-vaccine post-vaccine response Prevalence provide recipient remained RNA vaccines robust SARS-CoV-2 SARS-CoV-2 antibody secure sensitivity sera serological serum simple specificity specimen specimen collection Vaccine viral infection WHO [DOI] 10.1038/s41598-022-05640-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responsesArticle Published on 2022-02-032022-10-31 Journal: Cell [Category] COVID-19, [키워드] Abstract ACE2 ACE2 binding ACE2 binding site ameliorated Analysis antibody Beta binding Booster vaccine change changes in comprehensive analysis convalescent convalescent patient COVID-19 pandemic Delta driven by Evolution facilitate failure Gamma Immune escape immune evasion mAb monoclonal antibody Mutation neutralization neutralization titers neutralize Neutralizing antibody response new SARS-CoV-2 omicron pandemic RBD receptor receptor interaction receptor-binding motif reduce reduced reduction in reported reveal SARS-CoV-2 selective sequence sera spike subject the SARS-CoV-2 titer vaccinated individual vaccine dose vaccinee vaccinees Vaccines variant variants virus viruses widespread [DOI] 10.1016/j.cell.2021.12.046 PMC 바로가기 [Article Type] Article
Hidden fraction of Polish population immune to SARS-CoV-2 in May 20212021년 5월에 SARS-CoV-2에 면역된 폴란드 인구의 숨겨진 부분Research Article Published on 2022-02-032022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Anti-RBD IgG anti-SARS-CoV-2 antibodies Antigen antigens Asymptomatic can not collected convalescent COVID-19 COVID-19 pandemic cross-reactivity diagnosed estimation exclusion fraction HCoV HCoV 229E healthy individual healthy individuals herd immunity hospitalized COVID-19 patient hospitalized COVID-19 patients IgA IgA antibodies IgA antibody IgG immune Immunity individual Infection infections investigated Lower majority MERS-CoV modeling NL63 other coronaviruses pandemic Patient patients Population population immunity Population screening positive positive controls Protein public health Quantitative RBD Registered SARS-CoV SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2-specific IgG sera serum sample serum samples spike subject tested vaccination vaccination against COVID-19 Vaccinations virus virus-neutralizing Virus-specific IgG [DOI] 10.1371/journal.pone.0253638 PMC 바로가기 [Article Type] Research Article
Immunogenicity of BNT162b2, BBIBP-CorV and Gam-COVID-Vac vaccines and immunity after natural SARS-CoV-2 infection—A comparative study from Novi Sad, SerbiaBNT162b2, BBIBP-CorV 및 Gam-COVID-Vac 백신의 면역원성과 자연 SARS-CoV-2 감염 후 면역 - 세르비아 Novi Sad의 비교 연구Comparative Study Published on 2022-02-022022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age analyzed anti-S antibody antibody antibody levels BBIBP-CorV BNT162b2 challenge convalescent COVID-19 COVID-19 pandemic COVID-19 vaccine cross-sectional cross-sectional study DiaSorin followed by Gam-COVID-Vac Gam-COVID-Vac vaccine group IgG immune response Immunity immunogenicity individual investigated Italy Kruskal–Wallis test less LIAISON LIAISON SARS-CoV-2 S1/S2 IgG assay majority mass vaccination mean value no statistically significant difference Novi Sad of BNT162b2 Participants percentage Result robust S1/S2 SARS-CoV-2 second dose second dose of vaccine sera seroconversion rate seroconversion rates seroconverted seropositive serum Significant significant differences significantly higher statistically significant difference Vaccine vaccine dose Vaccines was collected was measured was used Wilcoxon rank-sum [DOI] 10.1371/journal.pone.0263468 PMC 바로가기 [Article Type] Comparative Study
Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine : Secondary Analysis of a Randomized TrialmRNA-1273 백신 2회 및 3회 접종 후 이식 수혜자의 SARS-CoV-2 변이체 중화: 무작위 시험의 2차 분석Randomized Controlled Trial Published on 2022-02-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Alpha Alpha variant Analysis analyzed Antibody Response assays Beta Beta variant Controlled trial COVID-19 delta variant Delta variants dose doses double-blind increase lentivirus mRNA mRNA vaccine mRNA-1273 mRNA-1273 vaccine neutralization neutralizing antibody Neutralizing antibody response neutralizing antibody responses Organ transplant Patient percentage points Placebo placebo group positive proportion Pseudovirus neutralization assay Randomized recipient recipients SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants secondary sera the placebo group Transplant vaccine doses vaccine immunogenicity variant variants Virus neutralization viruses wild-type virus [DOI] 10.7326/M21-3480 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants순차적으로 면역 유도된 항체는 SARS-CoV-2 변이체를 교차 중화할 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Animal models and experimental medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody B.1.1.529 collected cross-neutralize cross-neutralize SARS-CoV-2 cross-neutralizing delta variant Delta variants demonstrated dose geometric mean geometric mean titer geometric mean titers GMT GMTs Human human sera Humoral immunity immune Immunity in vitro inactivated Inactivated vaccine lead Mutation neutralization Neutralization antibody neutralization titers Neutralizing activity neutralizing antibody omicron Omicron variant PiCoVacc Protein raised Recombinant protein reduction in SARS-CoV-2 SARS-CoV-2 variant sequentially immune. sera Spike protein target the spike protein vaccination Vaccine variant wild type ZF2001 [DOI] 10.1002/ame2.12216 PMC 바로가기 [Article Type] Article
Fingolimod impairs inactivated vaccine (CoronaVac)-induced antibody response to SARS-CoV-2 spike protein in persons with multiple sclerosisFingolimod는 다발성 경화증 환자에서 SARS-CoV-2 스파이크 단백질에 대한 불활성화 백신(CoronaVac) 유도 항체 반응을 손상시킵니다.Article Published on 2022-02-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody Antibody Response CoronaVac coronavirus COVID-19 ELISA fingolimod healthy individuals humoral impair impairing inactivated Inactivated vaccine Multiple multiple sclerosis participant Person Prevalence recruited SARS-CoV-2 SARS-CoV-2 spike protein sera significantly lower spike IgG Support Treatment vaccination Vaccinations Vaccine were measured [DOI] 10.1016/j.msard.2022.103524 PMC 바로가기 [Article Type] Article