Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral targetResearch Article Published on 2020-08-282022-11-01 Journal: Science Advances [Category] COVID-19, MERS, [키워드] antiviral efficacy antiviral target AP2M1 cause conserved coronavirus COVID-19 Endoplasmic reticulum Host host protein Human immunodeficiency virus IAV in vitro in vivo influenza A virus Interaction mechanism MERS-CoV motif Mutation nuclear offer pandemic pathogenic virus Protein protein-protein interaction Proteins reveal SARS-CoV-2 targeting Viral proteins viral replication virus Zika virus ZIKV [DOI] 10.1126/sciadv.aba7910 PMC 바로가기 [Article Type] Research Article
Can Immunization of Hens Provide Oral-Based Therapeutics against COVID-19?Review Published on 2020-08-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-infective agents antibodies antibody Antigen Can caused chicken coronavirus 2 coronavirus disease COVID-19 Diseases effective effective drugs epitope highlight immune therapy immunization Immunoglobulin peptide polyclonal produced prophylactic treatment Prophylaxis prophylaxis strategy respiratory respiratory viral diseases Safe SARS-CoV-2 Specific Therapeutics therapy Vaccine Viral proteins worldwide pandemic [DOI] 10.3390/vaccines8030486 PMC 바로가기 [Article Type] Review
Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanismsArticle Published on 2020-08-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] ACE2 acute respiratory syndrome binding caused Contact coronavirus coronavirus disease COVID-19 disrupt drug Dynamics ENhance enzyme evaluate Host host receptor Hydrogen bond Interaction mechanism molecular Molecular dynamics simulation Molecular modelling pandemic performed Protein public health Receptor binding domain reported residue residues Salt Bridge SARS virus SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein Spike protein stability STABLE Structure suggested the binding affinity Treatment unique Viral proteins virus entry [DOI] 10.1038/s41598-020-71188-3 PMC 바로가기 [Article Type] Article
Human post‐infection serological response to the spike and nucleocapsid proteins of SARS‐CoV‐2Short Article Published on 2020-08-252022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] COVID-19, [키워드] antibodies average characterized collected comparable COVID‐19 COVID‐19 patient Epidemiology Frequency Human individuals nucleocapsid nucleocapsid protein response SARS‐CoV‐2 SARS‐CoV‐2 sera serological response serology specificity spike tested Viral proteins [DOI] 10.1111/irv.12798 PMC 바로가기 [Article Type] Short Article
Activation and evasion of type I interferon responses by SARS-CoV-2Article Published on 2020-07-302022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] Activation Analysis antagonistic effect Antimicrobial responses block C-terminus COVID-19 Critical downstream Effects global public health Host host innate immunity IFN IFN-β induce information inhibit innate immune response Innate immunity interferon interferons M protein modulating nonstructural proteins opposite ORF3 ORF6 pandemic pandemic of COVID-19 pathogenesis of SARS-CoV-2 promoter provide public health response responses S protein SARS-CoV-2 SARS-CoV-2 NSP1 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 replication Signaling Treatment Type I IFN type I interferon viral infection viral pathogen Viral proteins [DOI] 10.1038/s41467-020-17665-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responsesArticle Published on 2020-07-142022-10-04 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] age antibody Antibody Response Convalescent patients COVID-19 COVID-19 in patient diagnostic effective generate Human immune system IgG IgG and IgM immune system lactate dehydrogenase LDH lymphocyte Microarray N proteins nsp5 Orf9b Patient predicted Protein Protein array analysis Proteins provide respond response S1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 proteome sera the N protein the SARS-CoV-2 therapeutic Vaccination strategies viral infection Viral proteins [DOI] 10.1038/s41467-020-17488-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonistsResearch Article Published on 2020-06-202022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] activities Amino acid antagonist antagonists caused Characteristics contribute Coronavirus disease 2019 COVID-19 deaths demonstrated deubiquitinase Health Immune suppression Infection interferon interferon antagonist intranasal novel SARS-CoV-2 virus nsp13 nsp14 Nsp15 ORF6 outbreak PLPro protease SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence similarity suppress the SARS-CoV-2 unique Vaccine viral pathogenesis Viral proteins [DOI] 10.1080/22221751.2020.1780953 PMC 바로가기 [Article Type] Research Article
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particlesArticle Published on 2020-06-052023-08-30 Journal: Nature Communications [Category] E형 간염, [키워드] human Papilloma virus Protein vaccines Viral proteins [DOI] 10.1038/s41467-020-16639-1 PMC 바로가기 [Article Type] Article
Virtual screening of immunomodulatory medicinal compounds as promising anti-SARS-COV-2 inhibitorsResearch Article Published on 2020-05-212022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome acute toxicity Analysis analyzed Antiviral antiviral activity binding energy cause Compound compounds Coronavirus-2 disease distribution Drug repurposing Evidence ferulic acid Genistein Hydrogen bond immunomodulatory inhibitor Interaction material metabolism molecular docking morbidity Mortality nonstructural protein pharmacokinetic pharmacokinetics Proteases provide residue responsible resveratrol severe acute respiratory syndrome-2 significant interaction Spike protein these compounds Toxicity Treatment viral disease Viral protein Viral proteins virus [DOI] 10.2217/fvl-2020-0079 PMC 바로가기 [Article Type] Research Article
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article