Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation단순 비뇨 생식기 임질 치료를 위한 게포티다신: 2상, 무작위, 용량 범위, 단일 경구 용량 평가Articles and Commentaries Published on 2018-08-152022-09-07 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 1:1 95% confidence interval adverse event adverse events Antibiotics Bacterial baseline clinical collected Culture cure demonstrated dose drug-resistant effective Efficacy and safety enrolled evaluated Gender gepotidacin gonorrhea groups highest infections inhibitor inhibitory concentration isolate isolates microbiologically Mutation Neisseria gonorrhoeae New participant Participants pharyngeal Phase 2 Phase 2 study Randomized receive rectal rectal specimens rectal swab Registration specimen stratified susceptibility Swab therapeutic option Treatment urogenital [DOI] 10.1093/cid/ciy145 PMC 바로가기 [Article Type] Articles and Commentaries
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial아프리카에서 HIV에 대한 늦은 발표: REALITY 시험의 표현형, 위험 및 위험 계층화Advanced HIV Disease Published on 2018-04-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] Africa age albumin Antiretroviral therapy ART baseline CD4 CD4 count CD4 counts children clinical Cox regression died enrolled Fat mass Fever FIVE Follow-up grip strength group Health Organization hemoglobin high mortality highest HIV Human immunodeficiency virus identify Immunocompromised Immunosuppression individual infected individuals Intensive investigated Kenya laboratory feature median Mobility Mortality neutrophil neutrophil count neutrophil counts Older Older age Participants Patient Phenotypes Platelet poor mobility predictor presentation problem problems Prophylaxis reduced Registration remaining group Result self-care symptom burden Trial Uganda vomiting weight loss white cell World Health Organization Zimbabwe [DOI] 10.1093/cid/cix1142 PMC 바로가기 [Article Type] Advanced HIV Disease
Full-length genome sequences of porcine epidemic diarrhoea virus strain CV777; Use of NGS to analyse genomic and sub-genomic RNAsResearch Article Published on 2018-03-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] affected Analysis Cell culture characterized coding region coronavirus deletions determine diarrhoea disease Epidemic expression feature full-length genome gene product Genome genome sequence genomic highest infected cells Laboratory NGS ORF3 PEDV performed Point mutation predicted premature termination proportion protocols reference sequence RNA sequence Sequencing Spike protein sub-genomic mRNA Variability variant virus virus strain [DOI] 10.1371/journal.pone.0193682 PMC 바로가기 [Article Type] Research Article
Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, ChinaOriginal Article Published on 2017-12-062022-10-31 Journal: European Journal of Clinical Microbiology & Infect [Category] Coronavirus, MERS, [키워드] 229E age children China Clinical characteristics clinical feature clinical manifestation Clinical sign collected coronavirus coughing Epidemiology Evidence Fever group Guangzhou, China highest HKU1 Hospitalized Human human coronavirus Infection less NL63 OC43 Patient PCR Pediatric patient Pneumonia polymerase chain positive Prevalence provide rale respiratory diseases Respiratory pathogens respiratory tract infection respiratory virus Retrospective study significant difference strain subtropical Symptoms tested throat swab [DOI] 10.1007/s10096-017-3144-z PMC 바로가기 [Article Type] Original Article
Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia튀니지 수스 지역에서 아동 입원의 원인 병원체의 역학 및 임상 프로필Research Article Published on 2017-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, 폐렴구균 감염증, [키워드] 229E addition Adenovirus age analyzed association C-reactive protein children clinical manifestation clinical symptom collected Concentration coronavirus distribution DNA exhibited Frequency gastroenteritis highest HKU1 Hospitalization Hospitalized identify incidence increase Infection infections métapneumovirus multiplex NL63 OC43 oxygen support pathogen pneumoniae positive rDNA Real-time PCR real-time RT-PCR respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory tract infection respiratory virus responsible rhinovirus risk of death RSV screened Sousse statistically Streptococcus pneumoniae tested virus [DOI] 10.1371/journal.pone.0188325 PMC 바로가기 [Article Type] Research Article
Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?Article Published on 2017-10-162022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] amino acid substitutions Analysis analyzed animal clade Codons dromedaries Dromedary Evolution FIVE GenBank highest Host implication Infection intermediate Lineage lineages MERS MERS coronavirus MERS-CoV MERS-CoV genome molecular origin recent Recombination recombination event reservoir residue S protein Saudi Arabia selected sequence Spike protein strain Strains while [DOI] 10.3390/ijms18102138 PMC 바로가기 [Article Type] Article
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study자궁 경부 종양에 대한 유전적 감수성 정의 - 전체 게놈 연관 연구Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele amino-acid Antigen approaches association biological basis Cancer cancer development carried cervical cancer Combination complex correlation demonstrated determine determined by DRB1 error foundation Future Genetic genetic loci genetic risk genetic risk score genetic risk scores genetic susceptibility Genetic variant genetic variants Genome-wide association study healthy controls highest HLA HLA alleles HLA haplotype HLA-B HLA-DRB1 host genetics HPV human leukocyte antigen human papillomavirus identify immune immune-related protein immune-related proteins include increased risk indicated Infection inheritance involved leukocyte major histocompatibility complex MHC MHC alleles neoplasia performed pocket Previous studies previous study Prognosis progression Protective residue risk risk factor Risk factors screening methods standard error statistical the major histocompatibility to define Treatment variant women [DOI] 10.1371/journal.pgen.1006866 PMC 바로가기 [Article Type] Research Article
The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015Case Report Published on 2017-07-142022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory distress Admission analyzed antiviral agent ARDS center Chest Clinical course commenced Complete Complete genome Course Diagnosis discharged early treatment epidemiological feature Fever genetic analysis genome sequence highest hospitals hypoxia index case Infection infection control infiltration Intubated Korea Korean Laboratory Measures MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus myalgia occurred outbreak patchy Patient patients PCR rehabilitation respiratory syndrome coronavirus resulting ribavirin Saudi Arabia secondary transmission sequence similarity South Korea sputum supportive care syndrome the patient therapy Transmissibility Treatment Variation Ventilator associated pneumonia Virological virus Whole-genome sequence [DOI] 10.1186/s12879-017-2576-5 PMC 바로가기 [Article Type] Case Report
Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험Articles Published on 2017-05-052022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used [DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles
Cross-sectional survey of selected enteric viruses in Polish turkey flocks between 2008 and 2011Research Article Published on 2017-04-142022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] age Analysis analyzed astrovirus Bacteria chi-square test clinical Co-infection conducted coronavirus country demonstrated disease enteric enteric diseases Enteritis etiology evaluate examined Health Health status healthy help highest indicated Infection Intensive intestinal tract investigated logistic regression model molecular non-structural protein Occurrence parasites Parvovirus Poland positive Prevalence processed Region Research Result resulting RNA-dependent RNA polymerase rotavirus selected Seven simultaneously infected statistical statistically Statistics susceptible These viruses Turkey viral infection virus viruses were infected were used [DOI] 10.1186/s12917-017-1013-8 PMC 바로가기 [Article Type] Research Article