Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide TypeArticle Published on 2016-11-282022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 229E acid Activation activities Alter amide amide bond anticancer Antioxidative antioxidative activity Antiviral antiviral activity binding Biological CAD Cell cell line chloride cinnamic acid derivative Compound compounds Concentration concentrations conjugate Conjugates coronavirus cytostatic activity derivative DPPH evaluated Evidence functional group Hela highest inhibitor inhibitory activity LOX MCF-7 morphology motif novel performed primaquine reducing reported selective spacer synthesis Type [DOI] 10.3390/molecules21121629 PMC 바로가기 [Article Type] Article
Predicting the international spread of Middle East respiratory syndrome (MERS)Research Article Published on 2016-07-222022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] AIC Airline transportation network Akaike information criterion Analysis analyzed Area assumed AUC calculated coronavirus country covariate distribution effective estimate facilitated help highest importation IMPROVE incidence Infectious disease Intensive International majority MERS MERS coronavirus Middle East Middle East respiratory syndrome Muslim predict Predictive reported Result risk Risk assessment Saudi Arabia sensitivity skewed specificity Spread statistical model Support syndrome Transmissibility Transmission model were used [DOI] 10.1186/s12879-016-1675-z PMC 바로가기 [Article Type] Research Article
Global research trends of Middle East respiratory syndrome coronavirus: a bibliometric analysisResearch Article Published on 2016-06-072022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] activity acute respiratory syndrome Analysis article articles average Bibliometric cause Characteristics clinical symptom coronavirus country database exhibited Germany high mortality rate highest humans include International Kingdom MERS-CoV Metrics Middle East Middle East respiratory syndrome Coronavirus outbreak parameter produced proportion rapid increase Region Research respiratory syndrome coronavirus Result Saudi Arabia Scopus searched severe viral pneumonia similarity Spread syndrome USA virus was performed were excluded [DOI] 10.1186/s12879-016-1600-5 PMC 바로가기 [Article Type] Research Article
The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective StudyResearch Article Published on 2016-05-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Admission age association blood sample Bronchiolitis children clinical presentation coronavirus detect disease etiological examined febrile Follow-up gastroenteritis healthy control healthy controls highest Hospitalized Human nasopharyngeal NP swab Patient polymerase positive proportion Prospective Prospective Study Registration remains uncertain role Seizure specimen specimens Stool Surgical Procedure Swab variety virus viruses was used [DOI] 10.1371/journal.pone.0155555 PMC 바로가기 [Article Type] Research Article
S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigenResearch Published on 2016-04-012022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] affinity age analysed binding Cell cellular receptor clinical parameter colostrum Complete contagious diarrhea disease effective ELISA epidemic diarrhea Epitopes eukaryotic exhibited expressed expression highest identify IgA IgG immune response immunization immunized improvement infecting Infection intramuscularly Lactogenic immunity less mammalian mammalian cell morbidity and mortality Mortality N-terminal neutralizing antibody Newborn no significant difference PEDV pregnant produced PROTECT Protein Recombinant S1 protein responsible Result S1 S1 domain S1 protein S1 subunit SDS-PAGE sera serum significantly lower Spike protein subunit Subunit vaccine tested titre transferred vaccination Vaccine vaccine antigen virus Virus neutralization virus neutralization assays virus spike protein yeast [DOI] 10.1186/s12985-016-0512-8 PMC 바로가기 [Article Type] Research
Characterization and analysis of an infectious bronchitis virus strain isolated from southern China in 2013Research Published on 2016-03-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Affect Analysis bronchitis caused characterization China Complete Evolution Genes Genome Genome sequencing highest IBV identity indicated Infectious Bronchitis Virus insertion involved mechanism Mutation parental performed Phylogenetic analysis Prevalence Recombination Result Sequence analysis severe disease strain Strains subgroups Taiwan the disease vaccine strain Variation [DOI] 10.1186/s12985-016-0497-3 PMC 바로가기 [Article Type] Research
High Prevalence and Putative Lineage Maintenance of Avian Coronaviruses in Scandinavian WaterfowlResearch Article Published on 2016-03-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Ana Anseriforme avian CoV Charadriiforme collected coronavirus CoV CoVs described distribution duck Epidemiology Evolution feature fraction genetic diversity Gull highest Host imperative Infectious disease Lineage maintenance Mallard positive sample Prevalence risk screened sequence subsequent sequencing Surveillance variety virus zoonotic [DOI] 10.1371/journal.pone.0150198 PMC 바로가기 [Article Type] Research Article
A Porcine Epidemic Diarrhea Virus Outbreak in One Geographic Region of the United States: Descriptive Epidemiology and Investigation of the Possibility of Airborne Virus SpreadResearch Article Published on 2015-12-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis ArcGIS collected Contact determine disease disease spread dissemination epidemic diarrhea evaluated Geographic highest Hypothesis incidence increased risk indicated Infection information investigation mechanisms outbreak pathogen positive potential mechanism predominant Randomly Region Research Spread suggested Support The United States Transmission virus were used [DOI] 10.1371/journal.pone.0144818 PMC 바로가기 [Article Type] Research Article
Genetic Characterization of the Belgian Nephropathogenic Infectious Bronchitis Virus (NIBV) Reference Strain B1648Communication Published on 2015-08-072022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accessory protein Amino acid Analysis B1648 Belgium characterization chicken circulating Complete complex determinant Europe Evolution Factor full-length genome Genetic genomes Genotype Gray highest IBV identify indicated Infectious Bronchitis Virus Intensive M protein Massachusett nephropathogenic NGS nonstructural protein North Open reading frame ORF ORFs Phylogenetic analysis predicted reference reported sequence sequence homology Sequencing Spike protein strain Strains transcriptase vaccination variant virulent was determined [DOI] 10.3390/v7082827 PMC 바로가기 [Article Type] Communication
Evaluation of Four Commercial Multiplex Molecular Tests for the Diagnosis of Acute Respiratory InfectionsResearch Article Published on 2015-06-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory infections AdV Analysis Antimicrobial therapy approach ARI Clinical management clinical sample core correlation Diagnosis diagnostic documentation French help highest Infection influenza A Laboratory morbidity and mortality multiplex nucleic acid Panel pathogen Patient positive PPV Predictive protocol Real-time PCR respiratory respiratory specimen responsible risk significant effect specificity Spread Test tested the disease track university [DOI] 10.1371/journal.pone.0130378 PMC 바로가기 [Article Type] Research Article