Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responsesResearch Published on 2016-09-072023-06-07 Journal: Respiratory Research [Category] Fulltext, 신종인플루엔자, [키워드] COPD HBEC Human Influenza Innate immunity interferon lung RIG-I TLR3 [DOI] 10.1186/s12931-016-0428-2 PMC 바로가기 [Article Type] Research
Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic studyOriginal Article Published on 2016-09-012023-06-08 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] HA pyrosequencing 2009 pandemic immunohistochemistry Influenza lung [DOI] 10.1111/irv.12410 PMC 바로가기 [Article Type] Original Article
Assessment of pathogenicity and tissue distribution of infectious bronchitis virus strains (Italy 02 genotype) isolated from moroccan broiler chickensResearch Article Published on 2016-06-082022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] affecting age amplification assessment bronchitis Cell chicken Clinical scoring Clinical sign conducted demonstrated distribution dominant epithelial hyperplasia exhibited four groups Genotype group groups histological induce infected organ Infectious Bronchitis Virus Infectious bronchitis virus (IBV) Inflammatory information inoculated Italy Italy 02 kidney kidney damage lamina propria lesion lesions lethargic lung macroscopic mass vaccination Massachusetts Morocco Mortality mucosal pathogen Pathogenecity Pathogenesis pathogenicity Post-infection Randomly Real-time PCR reported Respiratory disease Respiratory system Result serological response strain tested tissue tracheal Vaccine viral disease Viral RNA virus viruses were recorded [DOI] 10.1186/s12917-016-0711-y PMC 바로가기 [Article Type] Research Article
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathwayArticle Published on 2016-05-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] A549 cells Activation Analysis binding site dependent activation dose epithelial cell expression Genes human lung in vitro in vivo indicated induce inhibitor injection luciferase reporter assay lung lung tissues Macrophage infiltration MAPK mechanism Mouse models NF-κB nuclear translocation Papain-like protease pathway Plasmid PLPro pro-fibrotic promoter promoter region reduced response responsible ROS SARS Coronavirus SARS-CoV significantly siRNA STAT3 stimulated TGF-β1 transcription factor triggered triggering up-regulate up-regulating vimentin [DOI] 10.1038/srep25754 PMC 바로가기 [Article Type] Article
Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi ArabiaResearch Article Published on 2016-04-212022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] Abnormalities Administered Admission age Alanine ALT Analysis Anemia Characteristics chest X-ray clearance clinical feature Confounding Coronary artery disease coronavirus CoV creatinine CXR death determine Diagnosis disease effect of treatment Efficacy elevated evaluate evaluated Gender healthcare worker hypertension Hypoxemia increased survival independent Infection interferon beta Kingdom Laboratory Leukocytosis lung male MERS MERS CoV MERS-CoV middle Middle Eastern respiratory syndrome coronavirus Most patient multivariate logistic regression outcome overall mortality Patient PCR polymerase chain predictor randomized trial reduced renal respiratory respiratory rate Result retrospective retrospective cohort Saudi Arabia severity severity of illness survival the patient Treatment Treatment outcome treatment regimen Univariate analysis vomiting was performed was reduced [DOI] 10.1186/s12879-016-1492-4 PMC 바로가기 [Article Type] Research Article
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice미세소포 프로스타글란딘 E 합성효소-1 결핍 마우스에서 폐렴구균의 치명성 증가 및 결함 있는 폐 청소Article Published on 2016-04-082024-08-23 Journal: American Journal of Physiology - Lung Cellular and Molecular Physiology [Category] 폐렴구균 감염증, [키워드] bacterial pneumonia host defense lung microsomal prostaglandin E synthase prostaglandins Streptococcus pneumoniae [DOI] 10.1152/ajplung.00220.2015 PMC 바로가기 [Article Type] Article
The IL-1 cytokine family and its role in inflammation and fibrosis in the lungReview Published on 2016-03-212023-08-30 Journal: Seminars in immunopathology [Category] E형 간염, [키워드] fibroblast fibrosis IL-1 IL-18 IL-33 Inflammation lung [DOI] 10.1007/s00281-016-0559-z PMC 바로가기 [Article Type] Review
Replication and shedding of MERS-CoV in Jamaican fruit bats ( Artibeus jamaicensis )Article Published on 2016-02-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] bat cells cellular change Clinical sign Dipeptidyl peptidase 4 disease DPP4 Evidence expression Gene Expression highlight histopathological Hypothesis Infection inoculated intestinal tract intrinsic investigated investigation Jamaican fruit bat lung Lungs maintain MERS-CoV Middle East moderate receptor replicate replicated reservoir respiratory syndrome coronavirus spike glycoprotein Virus shedding zoonotic [DOI] 10.1038/srep21878 PMC 바로가기 [Article Type] Article
Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-CoronavirusResearch Article Published on 2015-12-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accompanied addition animal model antiviral agent Autopsy Brain cause damage Dipeptidyl peptidase 4 Efficacy evaluate exhibited expressing hDPP4 high mortality Human Infection Injury intranasal kidney liver lung Lungs Macrophage infiltration mechanism MERS-CoV MERS-CoV infection mice Middle East Mild Multi-organ damage Neuron neutrophil organ paralysis Pathogenesis peptidase positive Post-infection receptor respiratory Respiratory failure severe pneumonia spleen Symptom systemic inflammation the disease Transgenic mouse Vaccine viral burden viral replication [DOI] 10.1371/journal.pone.0145561 PMC 바로가기 [Article Type] Research Article
Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium폐 상피에서 KLF4 발현 및 케모카인 분비를 위한 폐렴구균 자가용해효소의 역할journal-article Published on 2015-10-012024-08-04 Journal: American Journal of Respiratory Cell and Molecular Biology [Category] 폐렴구균 감염증, [키워드] Inflammation Innate immunity lung Pneumonia Streptococcus pneumoniae [DOI] 10.1165/rcmb.2014-0024OC [Article Type] journal-article