RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cellsArticle Published on 2015-08-012023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] A549 AEC Human Influenza Innate immunity interferon lung PR8 RIG-I TLR3 [DOI] 10.1016/j.virol.2015.03.048 PMC 바로가기
Host Tissue and Glycan Binding Specificities of Avian Viral Attachment Proteins Using Novel Avian Tissue MicroarraysResearch Article Published on 2015-06-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attachment attachment protein binding binding pattern Coronaviral coronavirus CoV Critical dependent on glycan Host host cell hosts Infectious disease influenza virus H5N1 initial Interaction lung M41 Microarray novel organ organ system pathogen Pathogens platform predominant profile Protein reported respiratory tissue S1 protein selected sialic acid specificity susceptibility susceptible tissue tissues type I Validity virus [DOI] 10.1371/journal.pone.0128893 PMC 바로가기 [Article Type] Research Article
Arginase 1 activity worsens lung‐protective immunity against Streptococcus pneumoniae infection아르기나제 1 활성은 폐 보호 면역을 악화시켜 폐렴구균 감염에 대한 저항력을 감소시킨다.journal-article Published on 2015-06-012024-08-04 Journal: Neurogastroenterology and motility : the official [Category] 폐렴구균 감염증, [키워드] Alternative macrophage activation ARG1 IL-13 Inflammation lung [DOI] 10.1002/eji.201445419 [Article Type] journal-article
Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia내인성 조직 인자 경로 억제제는 생쥐 폐렴구균 폐렴에서 숙주 방어에 제한적인 영향을 미친다.journal-article Published on 2015-01-012024-08-04 Journal: Thrombosis and haemostasis [Category] 폐렴구균 감염증, [키워드] Bacterial infection Coagulation inhibitors Inflammation lung Streptococcus pneumoniae [DOI] 10.1160/TH14-12-1053 [Article Type] journal-article
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine modelsArticle Published on 2014-12-012023-06-25 Journal: American journal of physiology. Lung cellular and [Category] 신종인플루엔자, [키워드] cytokine lung mouse retinoic acid-inducible gene I. Toll-like receptor 3 [DOI] 10.1152/ajplung.00158.2014 PMC 바로가기
Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1세포-세포 상호작용 및 흡입된 일산화탄소와 레졸빈 D1에 의한 기관지 수축 유도 에이코사노이드 감소journal-article Published on 2014-11-152024-08-04 Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology [Category] 폐렴구균 감염증, [키워드] ischemia/reperfusion leukotrienes lung resolvins thromboxane transcellular eicosanoid biosynthesis. [DOI] 10.1152/ajplung.00166.2014 [Article Type] journal-article
Infection with MERS-CoV Causes Lethal Pneumonia in the Common MarmosetResearch Article Published on 2014-08-212022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] addition Analysis animal model cause common Comorbidities comparable complicate demonstrated different time point Dipeptidyl peptidase 4 disease Disease model Efficacy evaluate expression Extensive humans immune inflammatory pathways Interaction intranasal lack lesion lethal lung marmoset marmoset model MERS-CoV MERS-CoV infection Middle East Mild modeling moderate disease MOST ocular Pathogenesis post inoculation potential therapeutic agent predicted Protein receptor required respiratory syndrome coronavirus rhesus RNAseq robust severe disease severe pneumonia severity spike glycoprotein the disease translated treated treatment strategy Vaccine Viral load virus entry was tested while [DOI] 10.1371/journal.ppat.1004250 PMC 바로가기 [Article Type] Research Article
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
γ-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosisArticle Published on 2014-08-012023-06-25 Journal: American journal of physiology. Lung cellular and [Category] 신종인플루엔자, [키워드] Bacteria collagen fibrosis lung virus [DOI] 10.1152/ajplung.00300.2013 PMC 바로가기
Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform ExpressionMouse Genetic Resources Published on 2014-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] acute respiratory syndrome aligned base pair collaborative cross conserved coronavirus differential expression eight elements expression gene transcription Genetic variation Genome genomes genomic host response identify Infection influenza A virus instance isoform isoform differential expression junctions knowledge lung mice mouse transcriptome annotation Mutation novel Profiling proportion recorded respiratory respiratory virus resulting RNA sample RNA-Seq sequence sequenced strain Strains transcribed transcript transcriptional transcriptional profile transcriptional response Transcriptome transcripts unlikely Variation viral infection [DOI] 10.1534/g3.114.011759 PMC 바로가기 [Article Type] Mouse Genetic Resources