A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5)Article Published on 2014-05-232022-10-06 Journal: Vaccine [Category] 진단, [키워드] antigen-specific antibody BALB/c mice cause children Efficacy evaluate exacerbate expressing glycoprotein Histopathology Hospitalization Human immune individuals Infant Infection lung lung lesion mice morbidity and mortality parainfluenza virus Parainfluenza virus 5 platform protective immunity Protein respiratory respiratory syncytial virus responses RSV severe respiratory disease the vaccine vaccination Vaccine Vaccine development vaccine strain virus were used wild-type [DOI] 10.1016/j.vaccine.2014.03.049 PMC 바로가기 [Article Type] Article
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections안지오텐신 전환 효소 2는 치명적인 조류 인플루엔자 A H5N1 감염으로부터 보호합니다Article Published on 2014-05-062022-09-25 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] ACE2 administration alleviate angiotensin-converting enzyme 2 cause death rates develop downregulation enzyme expression flu H5N1 highly pathogenic human ACE2 inactivation Infection Influenza influenza A Influenza virus information lung lung failure Lung injury Medical research mice Mouse models outbreak Pandemics Pathologies Patient patients Potential treatment PROTECT Respiratory tract diseases serum Serum level severe lung injury severity supplementary material virus [DOI] 10.1038/ncomms4594 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus InfectionResearch Article Published on 2014-03-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Adaptive immune response addition Administered airway airways alveolar macrophage CD4 CD4 T cell CD8 T cell coronavirus Coronavirus infection Critical Depletion disease evaluated Frequency Hepatitis Human Infection Liposome lung lung tissue mice Mild modulating morbidity and mortality mouse Pathogenesis pulmonary Respiratory disease shown significant increase subsequent susceptible Treg virus [DOI] 10.1371/journal.pone.0090720 PMC 바로가기 [Article Type] Research Article
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism Meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
Pulmonary pathology in pediatric cerebral malariaarticle Published on 2013-12-312024-09-01 Journal: Med Hypotheses [Category] 말라리아, [키워드] Africa cerebral malaria immunohistochemistry lung macrophages malaria pediatric Tissue arrays [Article Type] article
The evolution of codon usage in structural and non-structural viral genes: The case of Avian coronavirus and its natural host Gallus gallusArticle Published on 2013-09-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Avian coronavirus Gallus gallus 100% conserved Alpha Amino acid CAI cellular coded codon codon adaptation index codon usage compared coronavirus different driving effective Evolution GC Gene Genes Genetic glycoprotein Host host gene immune intestinal kidney less Lineage lung molecular molecular basis Mutation natural selection non-structural proteins nucleocapsid oviduct Papain-like protease predicted Protein protein A relative Replication respiratory tract significantly spike spike gene subunit synonymous Topology viral spike virus Virus–host Vitamin D receptor was measured were used [DOI] 10.1016/j.virusres.2013.09.033 PMC 바로가기 [Article Type] Article
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
Recombinant parainfluenza virus 5 vaccine encoding the influenza virus hemagglutinin protects against H5N1 highly pathogenic avian influenza virus infection following intranasal or intramuscular vaccination of BALB/c miceArticle Published on 2013-01-012022-10-06 Journal: Journal of Virology [Category] 진단, [키워드] administration Antigen approach BALB/c BALB/c mice booster contraindication different effectively controlled Efficacy ENCODE expressing H5N1 highly pathogenic immune responses immunization inactivated Infection Influenza Influenza virus intramuscular intramuscular vaccination intranasal lung mucosal IgA response Neutralizing New pandemic parainfluenza virus Prevent PROTECT Protective recombinant required robust serum antibody response shown single vaccine tested the vaccine threat vaccination Vaccine Vaccine development Vaccines virion Virology virus virus replication viruses while [DOI] 10.1128/JVI.02330-12 PMC 바로가기 [Article Type] Article