SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaquesSARS-CoV-2는 붉은 털 원숭이에서 강력한 생식 중심 CD4 T 여포 도우미 세포 반응을 유도합니다Article Published on 2021-01-222022-09-10 Journal: Nature Communications [Category] 진단, 치료법, [키워드] Adaptive immunity Antibody Response Antibody responses Antiviral Blood CD4 Cell convalescent plasma COVID-19 follicular GC response GC responses generate Germinal center helper cell humoral induce induction Infectious diseases infused infusion lung lymph nodes Mild Monocytes Nucleocapsid proteins Peripheral blood plasma pro-inflammatory monocyte pro-inflammatory monocytes question receiving response rhesus rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serum IgG antibodies skewed stimulate Tfh Tfh cell Th1 the SARS-CoV-2 Viral viral infections Viral proteins [DOI] 10.1038/s41467-020-20642-x PMC 바로가기 [Article Type] Article
Enterovirus D68 molecular and cellular biology and pathogenesisJBC Reviews Published on 2021-01-212022-10-04 Journal: The Journal of Biological Chemistry [Category] 비임상, [키워드] accumulating acute flaccid myelitis Adaptive immunity AFM AFM, acute flaccid myelitis antigens cascade CDC, US Centers for Disease Control and Prevention cellular change changes in children contribute COVID-19, Coronavirus disease 2019 eIF4, eukaryotic initiation factor 4 EMG, electromyography study enterovirus Enterovirus D68 Epidemiology EV-A71, enterovirus A71 EV-D68, enterovirus D68 Genetic GI, gastrointestinal highlight hnRNP, heterogenous nuclear ribonucleoprotein host cell receptor host cells ICAM, intercellular adhesion molecule include Infection Injury Innate immunity iPS, induced pluripotent stem cell IRES, internal ribosome entry site IVIG, intravenous immunoglobulin MDA, melanoma differentiation–associated protein metabolism molecular molecular feature motor neuron NCS, nerve conduction study pathogen Pathogenesis pathogenic receptor Research respiratory virus responsible RIG, retinoic acid–inducible gene severe respiratory illness similarity strain therapeutic approaches TLR, Toll-like receptor Toxicity Viral RNA virulence virus replication widespread [DOI] 10.1016/j.jbc.2021.100317 PMC 바로가기 [Article Type] JBC Reviews
SARS-CoV-2 neutralizing antibodies in patients with varying severity of acute COVID-19 illness다양한 중증도의 급성 COVID-19 질병 환자의 SARS-CoV-2 중화 항체Article Published on 2021-01-212022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, 치료법, [키워드] acute COVID-19 illness Adaptive immunity antibody association Asymptomatic clinical disease convalescence Convalescent plasma therapy COVID-19 illness declined evaluate faster immunology individual Infection Infectious diseases Kinetics less Medical research Microbiology Mild mild illness moderate Moderate COVID-19 NAb NAbs neutralization test Neutralizing antibodies Pathogenesis Patient persistence SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody severity severity of illness significantly Support Vaccine development Viral viral neutralization virus [DOI] 10.1038/s41598-021-81629-2 PMC 바로가기 [Article Type] Article
Disease‐duration based comparison of subsets of immune cells in SARS CoV‐2 infected patients presenting with mild or severe symptoms identifies prognostic markers for severity경증 또는 중증 증상을 나타내는 SARS CoV-2 감염 환자의 면역 세포 하위 집합의 질병 기간 기반 비교는 중증도에 대한 예후 마커를 식별합니다.Comparative Study Published on 2021-01-162022-09-12 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, [키워드] absence adaptive adaptive immune cells Adaptive immunity addition Analysis analyzed Antibody titer association B cells CD8 T cells Cell dendritic cells determined by disease disease severity event expression flow cytometry follicular forms Frequency functional healthy subject help Humoral immunity Hyperactivation identification identify IgG IL‐6 Imbalance Immune cell immune cells Immune profile India indicated infected patient Infection innate immune cell Innate immune cells Lower lymphocyte Lymphocytes management material maturation mDC mDCs memory B cell memory B cells Mild modulation Monocytes Multivariate analysis Neutralizing antibody titer neutralizing antibody titers NK cells observation Older age pandemic Pathogenesis Patient patient cohort patients positive presenting PRNT PRNT50 Prognostic marker Prognostic markers receptor Result SARS CoV‐2 SARS‐CoV‐2 SARS‑CoV2 Severe case severe cases severe disease severe symptom severity Spectrum subset Symptoms T cell T cells T helper cells therapy understanding [DOI] 10.1002/iid3.402 PMC 바로가기 [Article Type] Comparative Study
Recent endemic coronavirus infection is associated with less-severe COVID-19최근의 풍토병 코로나바이러스 감염은 덜 심각한 COVID-19와 관련이 있습니다Article Published on 2021-01-042022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, 진단, 치료기술, [키워드] acquisition Adaptive immunity Cellular immune response common cold coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 disease manifestation Endemic endemic human coronavirus endemic human coronaviruses etiologic agents Frequency greater immune response immune responses individual Infection mitigate observation recent respiratory respiratory infection respiratory infections SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-COV-2 infection sequence homology severe coronavirus disease tested the patient [DOI] 10.1172/JCI143380 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19코로나19 위험 집단과 환자의 전염병 전 면역 레퍼토리에서 SARS-CoV-2 특이 항체 재배열Clinical Trial Published on 2021-01-042022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단, [키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody antibody sequence B cell B cell receptor B cell response biochemical Blood Cancer Clinical course Cohort coronavirus coronavirus disease courses COVID-19 detrimental effect disease severity element explain fraction Future groups healthy individual healthy individuals immune immunoglobulins immunology individual less memory Neutralizing neutralizing antibody occurred pandemic Patient patients with COVID-19 receptor recognize reflect resulting retrieved risk SARS-CoV-2 SARS-CoV-2 antibody sequence serological data solid cancer validation cohorts while [DOI] 10.1172/JCI142966 PMC 바로가기 [Article Type] Clinical Trial
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine면역원성이 높고 효과적인 홍역 바이러스 기반 Th1 편향 코로나19 백신530 Published on 2020-12-222022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immunity addition analyzed antibody antiviral efficacy Arm backbone candidate caused CD4 CD8 Coronavirus-2 country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective effective immunity Effective vaccines effort experiments expressing full-length S protein functional immune response genomic position gravity hamster identify IgG antibody immune immune responses Immunity immunogenic immunopathology in vivo induce insertion killing measles measles vaccine platform measles virus mice modulated mouse mouse-adapted SARS-CoV-2 multifunctional Neutralizing Patient Protective public health respiratory response S protein S protein expression Safe SARS-CoV-2 SARS-CoV-2 spike glycoprotein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significance significantly lower situation solution spike glycoprotein Spread Support T cell T cell response T cell responses Th1 immune bias the SARS-CoV-2 Threats vaccination Vaccine vaccine candidate variant virus virus load yielding [DOI] 10.1073/pnas.2014468117 PMC 바로가기 [Article Type] 530
Neuraminidase-specific antibody responses are generated in naive and vaccinated newborn nonhuman primates following virus infectionResearch Article Published on 2020-12-172023-06-08 Journal: JCI Insight [Category] Fulltext, 신종인플루엔자, [키워드] Adaptive immunity immunology Influenza Vaccines [DOI] 10.1172/jci.insight.141655 PMC 바로가기 [Article Type] Research Article
Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2Review Published on 2020-12-082022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation acute respiratory syndrome adaptive Adaptive immune response Adaptive immunity B and T cell immune response caused Cell China coronavirus disease COVID-19 Defense disease disease severity immune response Immunity innate immune response mechanism memory B Mortality Neutralizing antibody titer pandemic Patient patients Re-infection response SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 patients severe SARS-CoV-2 T cell viral clearance virus while [DOI] 10.3390/pathogens9121027 PMC 바로가기 [Article Type] Review
Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samplesLetter Published on 2020-12-042022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Adaptive immunity blood sample COVID-19 Cytotoxic T cell immune profiling Lymphocytes single-cell [DOI] 10.1038/s41392-020-00425-y PMC 바로가기 [Article Type] Letter