Emergence and Spread of B.1.1.7 Lineage in Primary Care and Clinical Impact in the Morbi-Mortality among Hospitalized Patients in Madrid, SpainArticle Published on 2021-07-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Admission Alpha variant B.1.1.7 B.1.1.7 lineage B1.1.7 lineage Burden of disease characterized clinical death rate declining deletions detect disease dominant emergence healthcare Impact increase in intensive care Mutation new SARS-CoV-2 no difference pandemic Patient patients treated positive result prevalent primary care Probability reached replacement respiratory sample S gene SARS-CoV-2 SARS-CoV-2 variant screened Spain Spread spread to the spike protein variant variants [DOI] 10.3390/microorganisms9071517 PMC 바로가기 [Article Type] Article
Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021일부 프랑스 지역에서 SARS-CoV-2 Delta 변종의 급속한 확산, 2021년 6월Rapid Communication Published on 2021-07-152022-09-10 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] 95% confidence interval Alpha Alpha variant analysed Analysis collected COVID-19 delta variant Epidemiology France French growth magnitude performed public health authorities Rapid Region regions RT-PCR RT-PCR test RT-PCR tests Simulations Spread Statistical modelling the SARS-CoV-2 Transmission variant virus [DOI] 10.2807/1560-7917.ES.2021.26.28.2100573 PMC 바로가기 [Article Type] Rapid Communication
Structural Evaluation of the Spike Glycoprotein Variants on SARS-CoV-2 Transmission and Immune EvasionSARS-CoV-2 전달 및 면역 회피에 대한 스파이크 당단백질 변이체의 구조적 평가Review Published on 2021-07-102022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] (Beta) ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant alteration angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.2 Beta binding affinity caused Cluster conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Delta domain Efficacy ENhance Epitopes Epsilon glycoprotein immune evasion immune responses include increase in induce information Iota lead Lineage lineages Mutation Neutralising Antibodies P.1 pandemic receptor reduction in respiratory S protein SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike mutations Spike protein Spike proteins spike variants structures target the S protein the Spike Transmission vaccination Vaccine vaccine efficacy variants of SARS-CoV-2 Viral viral fitness [DOI] 10.3390/ijms22147425 PMC 바로가기 [Article Type] Review
Antibodies Targeting Two Epitopes in SARS-CoV-2 Neutralize Pseudoviruses with the Spike Proteins from Different VariantsCommunication Published on 2021-07-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Alpha variant Analysis antibody B-cell epitope Beta Beta variant caused COVID-19 COVID-19 pandemic D614G effective epitope IgG immunize information linear neutralization neutralize Particle peptide Point mutation prevalent Prevent produced Protective pseudovirus purified required SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spike protein Spread targeting the Spike the spike protein Vaccine variant variants wild-type [DOI] 10.3390/pathogens10070869 PMC 바로가기 [Article Type] Communication
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization Research Published on 2021-07-082022-10-05 Journal: Nature [Category] 변종, [키워드] Alpha variant anti-RBD antibody Antibody neutralization AstraZeneca B.1.1.7 B.1.617 B.1.617.2 binding collected convalescent individual convalescent individuals COVID-19 COVID-19 vaccine Delta delta variant dominant dose epitope examined faster France immune evasion include India individual individual with COVID-19 individuals inhibitory effect less Lineage monoclonal antibodies monoclonal antibody Mutation N-terminal domain neutralization Neutralizing NTD onset of symptom other variants Pfizer RBD Region returned SARS-CoV-2 SARS-CoV-2 variant sensitivity sera Spike protein Spread spread to strain subtype the receptor-binding domain the SARS-CoV-2 the spike protein the vaccine titre Vaccine variants [DOI] 10.1038/s41586-021-03777-9 [Article Type] Research
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccinesSARS-CoV2[알파, 베타, 감마, 델타 및 람다]의 스파이크 돌연변이 변이체가 소단위 재조합 백신의 효능에 미치는 영향Review Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 변종, 진단, [키워드] (alpha (Alpha) (Beta ACE2 Alpha alpha and delta variants Alpha variant Analysis angiotensin Angiotensin-converting enzyme antibody Antigen B.1.1.7 B.1.351 B.1.617 Beta bind binding COVID-19 Delta delta variant described Efficacy elicited focus Gamma greater host cell human infection humans immune response immunization infection process Invasion Lambda mutated variant mutated variants Mutation neutralize Prevent Protein RBD receptor Receptor binding domain recombinant vaccine recombinant vaccines reported robust SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 specific antibodies specific antibody spike Spike protein subunit subunit protein vaccine Subunit vaccine subunit vaccines Vaccine Vaccine development vaccine efficacy variant variants variants of SARS-CoV-2 virus [DOI] 10.1016/j.bjid.2021.101606 PMC 바로가기 [Article Type] Review
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7SARS-CoV-2 스파이크 결실 H69/V70의 반복적인 출현과 알파 변이체 B.1.1.7에서의 역할Article Published on 2021-06-082022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Abstract ACE2 receptor acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant antibody antibody escape B.1.1.7 binding affinity cell entry cell-cell fusion cleaved coronavirus COVID-19 D614G Deletion deletions dependent on Effect Efficiency escape escape mutation faster functional immune escape mutation immune escape mutations impair increase independent lineages Infectivity loss of infectivity mechanism N439K Neutralizing antibodies occur Pseudotyped virus receptor binding motif Recurrent replacement report residue resistance respiratory SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike spike mutation Spike protein Spike proteins Surveillance syncytium formation The B.1.1.7 the SARS-CoV-2 virion virions wild-type Wuhan-1 Y453F [DOI] 10.1016/j.celrep.2021.109292 PMC 바로가기 [Article Type] Article