Peptides Corresponding to the Predicted Heptad Repeat 2 Domain of the Feline Coronavirus Spike Protein Are Potent Inhibitors of Viral InfectionResearch Article Published on 2013-12-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Anti-viral Antiviral effect antiviral efficacy caused clinically Concentration coronavirus Coronavirus infection cytotoxicity demonstrated effective Efficacy evaluated exhibiting Feline infectious peritonitis FIVE heptad repeat IFN-α immune-mediated disease Infection inhibit inhibited Interferon-α MTT overlapping peptide performed plaque potent reduction Repeat Result selected sequence spike synergistic the spike protein therapy viral replication [DOI] 10.1371/journal.pone.0082081 PMC 바로가기 [Article Type] Research Article
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virusClinical Trial Published on 2010-05-112022-10-06 Journal: Proceedings of the National Academy of Sciences of [Category] 진단, [키워드] acquisition Administered Adult Adults Analysis antibody antiviral activity Antiviral effect assays clinical evidence concentrations decrease different double-blind Effectiveness enrolled exhibiting Factors healthy subject Human increase in independent Infected infected children Infection intranasal mechanism mRNA multiple logistic regression murine model nasal nasal washe nucleocapsid number of infected PCR Placebo placebo-controlled study placebo-controlled trial Proinflammatory cytokine proportion Protein protein expression Randomized recipient recipients representing respiratory syncytial virus RNA RSV RSV infection safety profile saline placebo significantly lower siRNA subjects tested therapeutic Therapeutic approach therapy treat uninfected unique viral culture was measured wild-type [DOI] 10.1073/pnas.0912186107 PMC 바로가기 [Article Type] Clinical Trial
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research