Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S ProteasomeSARS-CoV-2 주요 프로테아제 및 20S 프로테아좀의 공유 억제제의 절대 결합 자유 에너지의 빠르고 효과적인 예측Article Published on 2022-05-042022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerated activities Amino acid applicability approach binding affinities binding affinity binding free energy cause computational method covalent bond COVID-19 COVID-19 pandemic Degradation drug Effect effective electrophilic energetics energy enzyme evaluate exploration Free globe inhibitor inhibitors inhibitors of SARS-CoV-2 interactions M pro modulation powerful tool prediction protease proteasome Protein protocol public health emergency reaction reservation robust SARS-CoV-2 shown significantly target Therapeutic strategies variant warhead water [DOI] 10.1021/jacs.2c00853 PMC 바로가기 [Article Type] Article
Home quarantine: A numerical evaluation of SARS-CoV-2 spread in a single-family house자가격리: 단독주택에서 SARS-CoV-2 확산 수치 평가Article Published on 2022-05-012022-09-11 Journal: Indoor air [Category] COVID19(2023년), SARS, 치료기술, [키워드] aerosol affected cause Concentration contagious Contamination coronavirus disease Coronavirus disease 2019 country COVID-19 Critical case critical cases droplet emission French home home quarantine hospital lack Numerical simulation parameter quarantine reduce response risk SARS-CoV-2 sick single-family house Spread Symptom the disease Transmission Transport Ventilation virus worldwide pandemic [DOI] 10.1111/ina.13035 PMC 바로가기 [Article Type] Article
The effect of an mRNA vaccine against COVID-19 on endothelial function and arterial stiffnessRandomized Controlled Trial Published on 2022-05-012022-10-04 Journal: Hypertension research : official journal of the Ja [Category] 바이오마커, 임상, 치료기술, 치료법, [키워드] administration adopted age arterial Arterial stiffness baseline Blood BNT162b2 mRNA brachial cause confidence interval COVID-19 COVID-19 pandemic COVID-19 vaccine Deterioration dose Endothelial dysfunction endothelial function evaluated High-sensitivity C-reactive protein hsCRP increase in Inflammation inflammatory markers median men Messenger RNA mRNA mRNA vaccine outcome participant Placebo Primary outcome pulse remained returned SARS-CoV-2 secondary outcome significantly the vaccine vaccination Vaccine were assessed [DOI] 10.1038/s41440-022-00876-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Correlation between vaccine coverage and the COVID-19 pandemic throughout the world: Based on real-world data백신 적용 범위와 전 세계 COVID-19 대유행 간의 상관관계: 실제 데이터 기반Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis benefit cause correlated correlation correlation coefficient Course Coverage COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine data set death effective Effectiveness excess mortality global health Government Health hospital ICU ICU patient ICU Patients Infection intensive care intensive care unit International Local Mortality not decreased outcome Patient percentage real-world data Reproduction rate severe disease Temporal analysis Transmission Treatment vaccination Vaccine Vaccines variant [DOI] 10.1002/jmv.27609 PMC 바로가기 [Article Type] Article
False positive Herpes Simplex IgM serology in COVID-19 patients correlates with SARS-CoV-2 IgM/IgG seropositivityCOVID-19 환자의 위양성 단순 헤르페스 IgM 혈청 검사는 SARS-CoV-2 IgM/IgG 혈청 양성과 상관관계가 있습니다Article Published on 2022-05-012022-09-12 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adding Adsorption cause caused correlation COVID-19 COVID-19 patient COVID-19 patients diagnosed enzyme-linked immunosorbent False positive Herpe herpes simplex Herpes simplex IgM Heterologous IgM IgM/IgG immunoassay Immunoglobulin immunoglobulins inhibiting Interference Laboratory features molecular non-specific Patient Pneumonia Polyvinylpyrrolidone positive reactive SARS-CoV-2 serological serology Significant simplex tested Viral pneumonia [DOI] 10.1016/j.diagmicrobio.2022.115653 PMC 바로가기 [Article Type] Article
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and TherapeuticsResearch article Published on 2022-05-012022-10-05 Journal: JACC: Basic to Translational Science [Category] 바이오마커, 유전자 메커니즘, [키워드] ADAMTS13 cardiovascular cardiovascular complication Case-control cause Cohort COVID-19 COVID-19 patient COVID-19 patients disease severity dominant driving finding FSTL3 identify Implications Injury loss-of-function marker mechanism Microvascular thrombosis Myocardial myocardial injury pathophysiology performed phenotype plasma proteomics protease Protein proteomics senescence Signaling Stress therapeutic Therapeutics [DOI] 10.1016/j.jacbts.2022.01.013 [Article Type] Research article
Impact of COVID-19 on the Onset and Progression of Alzheimer’s Disease and Related Dementias: A Roadmap for Future Research알츠하이머병 및 관련 치매의 발병 및 진행에 대한 COVID-19의 영향: 미래 연구를 위한 로드맵Review Published on 2022-05-012022-09-12 Journal: Alzheimer's & dementia : the journal of the Alzhei [Category] MERS, 진단, [키워드] absence Alzheimer's risk factor caregiver burden cause cognitive Cognitive impairment Cohort consequence consortia COVID-19 COVID-19 infection COVID-19 symptoms delerium Dementia Final Future Genetic polymorphism Health highlight hypothese identify Impact Infection infections Intervention Isolation knowledge lack Like longitudinal cohort model system MONITOR Neurological symptom Onset Perspective reduce risk SARS-CoV-2 Social service Survivors systemic inflammation Treatment [DOI] 10.1002/alz.12488 PMC 바로가기 [Article Type] Review
Face masking and COVID-19: potential effects of variolation on transmission dynamics안면 마스크와 COVID-19: 변이가 전파 역학에 미치는 잠재적 영향Article Published on 2022-05-012022-09-11 Journal: Journal of the Royal Society Interface [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity attack rate basic reproduction number cause COVID-19 Delta Differential equations dose Effect Effectiveness Epidemic epidemiological estimate face Face mask Face masks growth growth rate healthcare Immunity individual induce Infection infections Infectious diseases infectious dose initial Live virus Mask masking Metrics omicron parameter Particles pre-vaccination Prevalence Prevent reduce reducing respiratory infections SARS-CoV-2 severe disease severe infections Side-effect SIR model smallpox suggested susceptible individual susceptible individuals Transmission Transmission dynamics transmission rate variants variolation variolation. wild-type virus [DOI] 10.1098/rsif.2021.0781 PMC 바로가기 [Article Type] Article
Evaluation of patients with telogen effluvium during the pandemic: May the monocytes be responsible for post COVID-19 telogen effluvium?Observational Study Published on 2022-05-012022-10-04 Journal: Journal of cosmetic dermatology [Category] COVID19(2023년), SARS, 임상, [키워드] cause circulating monocyte Clinical characteristics conducted coronavirus disease COVID-19 COVID-19 diagnosis COVID-19-related complications demographic develop diagnosed with COVID-19 Diagnosis electronic medical records evaluate hair follicle hair follicles Hair loss incidence IQR laboratory parameter Macrophage mechanism mechanisms median Migration monocyte Monocytes Observational cohort study occurred pandemic Patient patients Peripheral blood Physical examination polymerase chain pro-inflammatory cytokine reported responsible RT-PCR SARS-CoV-2 suggested telogen effluvium the patient triggering factor was performed were recorded [DOI] 10.1111/jocd.14883 PMC 바로가기 [Article Type] Observational Study
[Case-fatality rates of SARS-CoV-2 infection according to Autonomous Communities during the second epidemic wave in Spain]Observational Study Published on 2022-05-012022-10-04 Journal: Semergen [Category] COVID19(2023년), SARS, 임상, [키워드] age Analysis Asturias Balearic Island calculated Canary Islands carried Case-fatality rate cause Ceuta city Confidence intervals correlation Council COVID-19 Daily death Department Desigualdad en salud English epidemic wave estimate First wave group Health inequality health system Infection information Letalidad management material men Ministry of Health monitoring Mortality para Prevalence Public Rate Registered REL reported resources SARS-CoV-2 SARS-COV-2 infection Sex Significant significantly significantly higher Spain Spanish System transferred Valencian Weighting women [DOI] 10.1016/j.semerg.2022.02.004 PMC 바로가기 [Article Type] Observational Study