Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the INSPIRATION/INSPIRATION-S studiesCOVID-19 중증 환자에서 중간 용량 대 표준 용량 예방적 항응고제 및 스타틴 요법 대 위약: INSPIRATION/INSPIRATION-S 연구의 이론적 근거 및 설계Article Published on 2020-12-012022-09-11 Journal: Thrombosis research [Category] 임상, [키워드] all-cause mortality Analysis anticoagulation antithrombotic therapy Arterial thrombosis atorvastatin bleeding Chain Reaction cohorts Composite Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 death double-blind eligibility criteria Enrollment Exploratory analyses Exploratory analysis extracorporeal membrane oxygenation factorial design hallmark hallmarks help hypothese Hypothesis immune response include independent inferiority inspiration intensity intention-to-treat intermediate limit liver enzyme liver enzymes major bleeding management manifestation matching placebo modified intention-to-treat Myopathy non-inferiority non-inferiority margin normal limit Odds ratio open open label Patient patients with COVID-19 per-protocol performed Placebo Platelet Platelet count polymerase chain polymerase chain reaction Prevent primary endpoint Prophylactic prophylactic anticoagulation question randomization Randomized Randomized controlled trial rationale Result reverse transcription reverse transcription polymerase chain reaction safety endpoint screened secondary endpoint Standard dose Standard-dose statin Stratified randomization subgroup tested therapy thrombocytopenia thrombosis thrombotic event Thrombotic events undergo Venous Thromboembolism Ventilator-free days VTE [DOI] 10.1016/j.thromres.2020.09.027 PMC 바로가기 [Article Type] Article
Remote continuous glucose monitoring during the COVID-19 pandemic in quarantined hospitalized patients in Denmark: A structured summary of a study protocol for a randomized controlled trial덴마크의 격리된 입원 환자에서 COVID-19 전염병 동안 원격 연속 혈당 모니터링: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-11-252022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, [키워드] 1:1 able to communicate addition Admission age Analysis association band-aid blinded blood glucose blood glucose monitoring calibrated Care CGM Clinical outcome clinically Confirmed COVID-19 infection Contact contagious disease contagious diseases contagious infection contagious infections Controlled trial COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 pandemic Date defined detect diabete diabetes diabetes - diabetes management Diagnosis Diagnostic Criteria dissemination distribution element Endpoint enrolled exclusion criteria exploratory female Finger prick form Glucose glucose control glycaemic control group groups Healthcare provider Hospitalization Hospitalized hospitalized patient hypersensitivity Hypothesis Identifier Improved In-hospital Inclusion inclusion criteria increased risk infected patients Infection infections Informed consent management masking MONITOR mounted must Non-COVID-19 not need number objective open open label outcome parallel group participant Patient patients with diabete performed Pneumonia PPE primary endpoint protocol quarantine randomisation randomised randomised controlled trial randomization randomization list Randomized Randomized controlled trial Real-time PCR recorded reduce remote reported required risk Sample size SARS-COV-2 infection secondary Secondary endpoints service stratified Study protocol subject supplementary material the patient the primary endpoint transmitted Trial trial protocol Trial registration Type 1 diabetes type 2 diabetes variable website World Health Organization written Informed Consent [DOI] 10.1186/s13063-020-04872-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Point-of-care molecular testing and antiviral treatment of influenza in residents of homeless shelters in Seattle, WA: study protocol for a stepped-wedge cluster-randomized controlled trial워싱턴주 시애틀의 노숙자 보호소 거주자를 대상으로 한 현장 진료 분자 검사 및 인플루엔자 항바이러스 치료: 계단식 쐐기형 클러스터 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2020-11-232022-09-10 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] acute respiratory illness Administered age Analysis Antiviral treatment ARI baloxavir Comorbidities Complete control arm Controlled trial defined demographics eligible Enrollment evaluate health problem homeless shelter Homeless shelters implementation incidence individual Influenza information Intervention intervention arm molecular nine oseltamivir participant point-of-care positive primary endpoint public health questionnaire Randomized reduce respiratory respiratory symptom Seattle severity Site Spread Study protocol supplementary material Surveillance symptom duration symptom onset Symptoms tested timepoint Trial Trial registration University of Washington Washington worsening cough [DOI] 10.1186/s13063-020-04871-5 PMC 바로가기 [Article Type] Study Protocol
Prone positioning in non-intubated patients with COVID-19 associated acute respiratory failure, the PRO-CARF trial: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-232022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 Acute respiratory failure Alpha Altered mental status approval asked awake prone-positioning blinded block calculated Chest clinical clinically contraindication control group Controlled trial COVID-19 data analyst decrease dissemination element eligibility eligible endotracheal Endotracheal intubation expected facial failure fatigue for inclusion fraction High-flow nasal cannula in both group intervention group intubation rate Invasive mechanical ventilation less Local maintain mechanical ventilation median MONITOR monitoring nasal need for oxygen non-intubated patient number objective offered outcome oxygen parallel group participant Patient patients patients with COVID-19 Pelvic Physicians Pillow positioning positive Pregnancy principal investigator prone Prone position prone positioning protocol randomised randomised controlled trial randomization Randomized Randomly recruit refusal Registered reported respiratory Respiratory failure Sample size screened staff Standard status stratified Study protocol supplementary material supplementary oxygen the patient therapy Thoracic Tolerance trauma Treatment vital sign website with COVID-19 [DOI] 10.1186/s13063-020-04882-2 PMC 바로가기 [Article Type] Letter
Impact of an e-learning module on personal protective equipment knowledge in student paramedics: a randomized controlled trial학생 구급대원의 개인 보호 장비 지식에 대한 e-러닝 모듈의 영향: 무작위 통제 시험Research Published on 2020-11-102022-08-09 Journal: Antimicrobial Resistance and Infection Control [Category] SARS, 임상, [키워드] 1:1 Adequacy Adequate ambulance service analyzed baseline benefit control group Controlled trial COVID-19 guidelines COVID-19 infection e-learning e-learning group e-learning module Emergency medical services evaluate gamified e-learning module help Impact increase Intervention knowledge no significant effect parallel-group paramedics Personal protective equipment physician post-intervention PPE Prehospital professional Primary outcome PROTECT question Randomized Randomized controlled trial Result School shown significantly statistically significant Student paramedics the median triple-blind [DOI] 10.1186/s13756-020-00849-9 PMC 바로가기 [Article Type] Research
Evaluation of the efficacy and safety of favipiravir and interferon compared to lopinavir/ritonavir and interferon in moderately ill patients with COVID-19: a structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-10-272022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 Adverse drug reaction allergy allocation sequence antibody tests anticipated Arm ARMS assigned Bandar Abbas Blinding block randomization Breastfeeding carried China cirrhosis clinical Clinical improvement company Computed tomography conditions Confirmed Control control group Controlled trial COVID-19 criteria Critical Department Diagnosis dissemination dose Efficacy and safety element evaluate Favipiravir Fever FIVE generate Hepatitis history Hospital stay Hospitalization ill patient in both groups incidence India infection with SARS-CoV-2 interferon intervention group Iran liver diseases Lopinavir/ritonavir nasopharyngeal sample number objective Open-label Other outcome parallel-group participant Patient patients Phase 3 Placebo Pneumonia polymerase chain Primary outcome protocol random randomization Randomized Randomized controlled trial receive registry renal respiratory routine care RT-PCR Sample size SARS-CoV-2 screened secondary outcome single-center Study protocol treatment arm Trial trial protocol two group Viral load web-based system website X-ray Zhejiang [DOI] 10.1186/s13063-020-04747-8 PMC 바로가기 [Article Type] Letter
Convalescent plasma transfusion therapy in severe COVID-19 patients- a safety, efficacy and dose response study: A structured summary of a study protocol of a phase II randomized controlled trial중증 COVID-19 환자의 회복기 혈장 수혈 요법- 안전성, 효능 및 용량 반응 연구: 2상 무작위 대조 시험 연구 프로토콜의 구조화된 요약Letter Published on 2020-10-262022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] (neutrophil 24 hour 24 hours allergic allergic reaction Antibody titre Arm ARMS automated blinded Blinding body temperature BSMMU Care checked Clinical improvement collaboration collected comparator computer Controlled Controlled trial convalescent plasma COVID-19 creatinine criteria CRP CT scan deaths defined diastolic discharge dissemination Donor donors dose dose response effective effective dose Efficacy Efficacy and safety element ELISA end point enrolled Evidence evidence of excluded expected FiO2 generate Health Organization hospital Hospital stay ICU identify in-hospital mortality inclusion criteria initial intervention arms Laboratory laboratory parameter Laboratory parameters Laboratory tests lactating women lung lymphocyte multi-arm multicentre neutralizing antibody neutrophil normality number objective open outcome Oxford oxygen oxygen saturations PaO2 paO2/fiO2 participant Participants Patient PCR assay performed plasma Plasma transfusion positive pregnant Primary outcome proportion protocol random number table randomised Randomized controlled trial RCT receive recorded recording recruit recruited recruitment reduction in required respiratory respiratory distress respiratory rate respiratory symptoms room air RT-PCR RT-PCR assay Sample size sample size calculation SARS-CoV-2 secondary outcome serum creatinine Serum ferritin Seven Severe case severe cases severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients Severe respiratory distress Sex SGOT SGPT SpO2 sputum standard care status Study protocol Support systolic the patient therapy These data titre transfusion Treatment Trial university University of Oxford ventilator website World Health Organization X-ray [DOI] 10.1186/s13063-020-04734-z PMC 바로가기 [Article Type] Letter
Hydroxychloroquine in the Treatment of COVID-19: A Multicenter Randomized Controlled StudyCOVID-19 치료의 하이드록시클로로퀸: 다기관 무작위 통제 연구Articles Published on 2020-10-142022-08-09 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 임상, [키워드] added Administered age and gender baseline characteristics benefit conducted control arm control group Controlled Controlled trial COVID-19 pandemic COVID-19 patients death decrease decreased mortality develop diagnosis of COVID-19 did not reduce died effective Efficacy evaluate exponential growth growth HCQ Hydroxychloroquine Informed consent Laboratory parameters Logistic regression analysis mechanical ventilation mortality rate mortality rates multicenter no significant difference not differ overall mortality Patient patients with COVID-19 primary endpoint primary endpoints Randomized Randomized controlled trial significantly standard care therapy Treatment two group two groups Univariate logistic regression analysis university hospital Ventilation [DOI] 10.4269/ajtmh.20-0873 PMC 바로가기 [Article Type] Articles
Acupuncture for corona virus disease 2019 A protocol for systematic review and meta analysis3800 Published on 2020-10-022022-10-30 Journal: Medicine [Category] COVID-19, MERS, SARS, [키워드] acupuncture Analysis Asia CBM Chest CT China Chinese CNKI Cochrane Library Controlled trial corona virus disease 2019 coronavirus disease COVID-19 database determine disease East effective Efficacy and safety evaluate Evidence include Infrastructure literature Nucleic acid detection outbreak outcome Patient Prevalence protocol researcher Respiratory disease Respiratory samples Science searched subject systematic review treat Treatment Virus Disease Web of Science [DOI] 10.1097/MD.0000000000022231 PMC 바로가기 [Article Type] 3800
Early identification of COVID-19 cytokine storm and treatment with anakinra or tocilizumabResearch article Published on 2020-10-012022-10-05 Journal: International Journal of Infectious Diseases [Category] Coronavirus, SARS, 치료법, [키워드] 95% confidence interval addition Anakinra anti-cytokine anti-cytokine treatment anti-inflammatory treatment Clinical severity conducted Controlled trial Corticosteroid Corticosteroids COVID-19 COVID-19 cytokine storm criteria Cytokine storm dead died disease severity Electronic health records had more hazard Intubated intubation Laboratory median objective outcome Patient patients died patients treated randomization Respiratory failure Result retrospective cohort study Sepsis Seven specific type statistically significant to define Tocilizumab treated Treatment treatment initiation treatment with anakinra variable [DOI] 10.1016/j.ijid.2020.07.081 [Article Type] Research article