epitope – Page 27 – Communicable Diseases Research

A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine

단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed
[DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Article

Published on 2022-02-152022-10-04
Journal: Cell Discovery [Category] 변종, 치료제,

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Fc 강화 NTD 결합 비중화 항체는 바이러스 확산을 지연시키고 nAb와 상승 작용하여 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다

Article

Published on 2022-02-152022-09-12
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단,

In-Silico Analysis of Monoclonal Antibodies against SARS-CoV-2 Omicron

Brief Report

Published on 2022-02-142022-10-28
Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS,

[키워드] affected analysed Analysis antibody antibody epitope bamlanivimab Casirivimab cilgavimab COVID-19 vaccines database epitope Epitopes EUA five groups Mutation mutations neutralisation NTD omicron regdanvimab SARS-CoV-2 sequence Sotrovimab spike mutation submitted the WHO therapeutic three group Tixagevimab Vaccine variant VoC
[DOI] 10.3390/v14020390 PMC 바로가기 [Article Type] Brief Report

SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants

Research Article

Published on 2022-02-142022-10-29
Journal: PLoS Pathogens [Category] COVID-19, COVID19(2023년), SARS,

[키워드] alleles Allogeneic Anti-viral Antigen approach can be used Cell Complication convalescent individual Coverage COVID-19 Critical Effectiveness epitope Evidence expand functional generate healthy HLA HLA class I humans immune immune system Immunocompromised patient Immunotherapy increased risk individual leukocyte observation offer Patient phenotypic powerful tool provided recognize recognizing reduce remain unchanged Repository Research risk robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell screened selected severe complication severe COVID-19 susceptible T cell T cells T-cell T-cell Response target transfer treat Treatment Vaccines variant variants of SARS-CoV-2 viral disease viral infections virus-specific T cell while with COVID-19
[DOI] 10.1371/journal.ppat.1010339 PMC 바로가기 [Article Type] Research Article

Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine

407

Published on 2022-02-112022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

[키워드] acute respiratory syndrome addition Affect Alpha antibody antigens Apoptosis broad spectrum can be used CD8 Cell conserved coronavirus COVID-19 DCs deleted dendritic cell development domain effective Efficacy elicited Endoplasmic reticulum epitope expressed expression glycosite deletion glycosylation histocompatibility complex immune response incubated induce Messenger RNA MHC I Modification mRNA mRNA vaccine mRNA vaccines Omicron variants Pathogens Protective Protein provide RBD S2 domain SARS-CoV-2 SARS-CoV-2 spike protein Significance Spike protein Spread subunit T cell response the RBD the receptor-binding domain translated vaccination Vaccine variant variants of concern viral spike protein wild type XBP1
[DOI] 10.1073/pnas.2119995119 PMC 바로가기 [Article Type] 407

Cellular Responses to Membrane and Nucleocapsid Viral Proteins Are Also Boosted After SARS-CoV-2 Spike mRNA Vaccination in Individuals With Either Past Infection or Cross-Reactivity

Microbiology

Published on 2022-02-112022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants

Coronaviruses

Published on 2022-02-102022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2

SARS-COV-2에 대한 세포 독성 반응에 대한 바이러스 돌연변이 풍경의 영향 예측 된 영향

Research Article

Published on 2022-02-102022-09-10
Journal: PLoS Computational Biology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종,

[키워드] accumulation adaptive affected affecting Algorithm allele Allele families allele family alleles antibodies Asian Author C-terminal change changes in Cluster complexity country COVID-19 susceptibility Critical Cytotoxic T cell deletions eight epitope Epitopes escape escape mutation event except for extreme facilitated genetic background genetic variability genetics Genome genomic HLA class I human allele human population humans immune evasion immune response independent information integration involved isolate isolates Ligand ligands local outbreaks Mutation mutations NCBI Neutralizing occurred pandemic Pandemics Population predicted Prevent Primary infection Protective proteome protocol reduction Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome selective subpopulations Substitution Support surpassed Surveillance susceptible T cell T cell response the SARS-CoV-2 unlikely Variability variant variants Viral viral genome viral genomes viral mutation Viral mutations viral variant virus
[DOI] 10.1371/journal.pcbi.1009726 PMC 바로가기 [Article Type] Research Article

Predicted 3D model of the M protein of Porcine Epidemic Diarrhea Virus and analysis of its immunogenic potential

Research Article

Published on 2022-02-092022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,