Safety and immunogenicity of two recombinant DNA COVID-19 vaccines containing the coding regions of the spike or spike and nucleocapsid proteins: an interim analysis of two open-label, non-randomised, phase 1 trials in healthy adults스파이크 또는 스파이크 및 뉴클레오캡시드 단백질의 코딩 영역을 포함하는 2개의 재조합 DNA COVID-19 백신의 안전성 및 면역원성: 건강한 성인을 대상으로 한 2개의 공개 라벨, 비무작위, 1상 시험에 대한 중간 분석Clinical Trial Published on 2022-03-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, 치료법, [키워드] adverse event adverse events analysed Antibody Response blood sample Blood samples coding region collected COVID-19 vaccine development DNA DNA vaccine domain dose of vaccination doses drug energy ENhance enrolled fatigue first vaccination group healthy hospital humoral immunogenicity individuals induce intention-to-treat population interim analysis intervals intramuscularly Mild Ministry of Health moderate neutralising antibody response nucleocapsid nucleocapsid protein Open-label participant Participants Phase 1 phase 1 trial Plasmid plasmid DNA positive Primary outcome RBD recombinant DNA Registered reported Safe Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-specific T-cell responses Science screened second dose secondary outcome Serological testing South Korea Spike protein T-cell responses tested the RBD the SARS-CoV-2 the spike protein the vaccines Trade treatment-emergent adverse event Trial trial participant trials vaccination Vaccine vaccine dose vaccine immunogenicity Welfare were excluded [DOI] 10.1016/S2666-5247(21)00358-X PMC 바로가기 [Article Type] Clinical Trial
Mind the “worry fatigue” amid Omicron scares오미크론 공포 속에서 "걱정하는 피로"를 염두에 두십시오.Review Published on 2022-03-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 변종, [키워드] accumulated addition analyses Burnout Compliance COVID-19 debate debates exacerbate extreme fatigue feeling Government Guidance Health health guidance Health Organization Measures media mind norm omicron Omicron variant outcomes pandemic preventive measures Public public health Public heath variant World Health Organization Worry Worry fatigue. [DOI] 10.1016/j.bbi.2021.12.023 PMC 바로가기 [Article Type] Review
Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19호흡기 증상이 아닌 염증성 증상은 합병증이 없는 COVID-19 외래 환자에서 진행 중인 상기도 바이러스 배출과 관련이 있습니다.Clinical Trial Published on 2022-03-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] SARS, 임상, 치료기술, [키워드] 14-18 95% confidence interval acute respiratory syndrome coronavirus airway approach approaches benefit characterized clinical trial Cohort coronavirus 2 coronavirus disease cough COVID-19 demonstrated enrolled Enrollment fatigue Fever greater hazard ratio implication Infection Inflammatory Lambda majority median time myalgias Oropharyngeal oropharyngeal viral shedding outpatients with uncomplicated peaked Placebo predictor respiratory respiratory symptom respiratory symptoms SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 RNA Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Symptom symptom clustering symptom onset symptom progression symptom resolution trajectory Trial viral shedding [DOI] 10.1016/j.diagmicrobio.2021.115612 PMC 바로가기 [Article Type] Clinical Trial
Protracted or recurrent COVID-19 associated cytokine storm in a patient with chronic lymphocytic leukemia receiving rituximab-based chemotherapy리툭시맙 기반 화학요법을 받고 있는 만성 림프구성 백혈병 환자에서 장기간 또는 재발하는 COVID-19 관련 사이토카인 폭풍Case Reports Published on 2022-03-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, 진단, [키워드] addition Administered Anakinra Chemotherapy Corticosteroids Course COVID-19 Cyclophosphamide Cytokine storm Cytokine storm (hyperinflammatory syndrome) diagnosed diagnosed with COVID-19 died discharge fatigue Fever hospital Hospitalization Hyperinflammatory Hypoxemia intravenously laboratory parameter leukemia male Methylprednisolone oxygen saturation Patient Prednisolone progressed receiving regimen resolved Respiratory failure rituximab severe hypoxemia Shortness of breath Significant the patient Tocilizumab Treatment vincristine [DOI] 10.1016/j.clim.2022.108936 PMC 바로가기 [Article Type] Case Reports
The Female-Predominant Persistent Immune Dysregulation of the Post-COVID SyndromeResearch article Published on 2022-03-012022-10-05 Journal: Mayo Clinic proceedings [Category] 유전자 메커니즘, [키워드] age Analysis approval C-reactive protein Care central sensitization chest pain Clinical data clinical phenotype clinical phenotypes Coronavirus disease 2019 COVID-19coronavirus disease 2019 CRPC-reactive protein CRScytokine release syndrome CScentral sensitization Cytokine release syndrome database Dyspnea elevated erythrocyte sedimentation rate ESRerythrocyte sedimentation rate facilitate fatigue female headache IL-6 level IL-6 levels ILInterleukin institutional review board interleukin interleukin 6 (IL-6 interquartile range Mayo Clinic men MOST myalgia objective PASCpost-acute sequelae of SARS-CoV-2 infection Patient PCOCCpost–COVID-19 care clinic persistent phenotype PoCoSpost-COVID syndrome Post-acute sequelae of SARS-CoV-2 infection post-COVID syndrome post–COVID-19 care clinic Postural orthostatic tachycardia syndrome POTSpostural orthostatic tachycardia syndrome predominant Result SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Sex the median the patient women [DOI] 10.1016/j.mayocp.2021.11.033 [Article Type] Research article
Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for the post-acute sequelae of COVID-19Research article Published on 2022-03-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 바이오마커, [키워드] activity autonomic Biomarker Brain cause caused cells changes in characterized chronic fatigue syndrome circadian rhythm cognitive coronavirus COVID-19 COVID-19 pandemic cytokine Depression disorder disrupting dysfunction Evidence examined fatigue growth factor immune implication Inconclusive increasingly Infection Inflammatory response Insomnia Major methodological molecular myalgic encephalomyelitis Older organ systems outbreak over overlap pandemic PASC Perspective physiological problem problems progressed reported Research SARS-CoV2 SARS-like coronavirus Signaling Sleep Symptoms temperature therapeutic interventions transforming growth factor beta viral infections while [DOI] 10.1016/j.bbih.2022.100412 [Article Type] Research article
Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors2082년 COVID-19 회복기 혈장 기증자의 증상, 기증자 특성 및 IgG 항체 반응 간의 연관성Observational Study Published on 2022-02-282022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] age Anosmia antibodies antibody Antibody Response association average body mass index CCP Characteristics concentrations convalescent plasma COVID COVID-19 COVID-19 symptom diarrhoea disease Donor donors dry cough Dyspnoea faster fatigue female Fever headache IgG IgG antibody less linear longitudinal male mixed-effects model MOST nasal outcome Patient performed questionnaire reported response retrospective SARS-CoV-2 antibody severity of COVID-19 Symptom Symptoms the SARS-CoV-2 unique weakness [DOI] 10.3389/fimmu.2022.821721 PMC 바로가기 [Article Type] Observational Study
[Monitoring the development of post-COVID–19 syndrome]Article Published on 2022-02-272023-07-08 Journal: Orvosi hetilap [Category] COVID19(2023년), [키워드] fáradékonyság fatigue olfactorian disorders post-acute COVID–19 syndrome poszt-COVID-szindróma SARS-COV-2 infection SARS-CoV-2-fertőzés szaglászavar. [DOI] 10.1556/650.2022.32432
Spontaneously reported persistent symptoms related to coronavirus disease 2019 one year after hospital discharge A retrospective cohort single-center studyOriginalien Published on 2022-02-252022-10-29 Journal: Schmerz (Berlin, Germany) [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome addressed Analysis asked Care chronic pain Chronische Schmerzen cognitive Cohort Complete conducted coronavirus disease COVID-19 COVID-19 symptom discharge dysfunction English False attribution fatigue Fehlattribution FIVE Germany headache hospital hospital discharge Hospitalization Hospitalized independent initiated joint Müdigkeit occurred outcome Pain Patient patients polymerase chain Post Covid-19 Post COVID-19 condition question reduce reported Result retrospective cohort study SARS-CoV-2 Shortness of breath single-center study survivor Symptom symptom onset the disease the patient [DOI] 10.1007/s00482-022-00626-0 PMC 바로가기 [Article Type] Originalien
Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohortCovid-19 Published on 2022-02-252022-10-31 Journal: European Journal of Epidemiology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI adjusted relative risk breath calculate Child Cluster cognitive Cohort cohort study correlation cough COVID COVID-19 COVID-19 pandemic COVID-19 patient Depression Dizziness excess explained Factor father fatigue identify Infection less mechanism memory MoBa moderate non-infected Occurrence participant Post-acute sequelae Psychological question Registered reported risk SARS-CoV-2 SARS-COV-2 infection strongly related subject subjects supplementary material swing Symptom Symptoms syndrome The Norwegian Mother, Father and Child Cohort Study uninfected [DOI] 10.1007/s10654-022-00847-8 PMC 바로가기 [Article Type] Covid-19