Impact of high dose of baricitinib in severe COVID-19 pneumonia: a prospective cohort study in Bangladesh중증 COVID-19 폐렴에서 고용량 바리시티닙의 영향: 방글라데시의 전향적 코호트 연구Clinical Trial Published on 2021-05-072022-08-13 Journal: BMC Infectious Diseases [Category] 임상, [키워드] 30-Day mortality 60-day rehospitalization rate Baricitinib Blood oxygen saturation level Clinical outcome clinical outcomes conducted COVID-19 infection COVID-19 pneumonia Critical care Cytokine storm declined functions groups HD group High dose hyperinflammation ICU Impact increase inflammatory cascade inflammatory cascades inhibitor intensive care intensive care unit intubation intubation support janus kinase kinases Mortality mortality rate oxygen oxygen saturation Patient prospective cohort study reduced rehospitalization required Respiratory failure respiratory functions Result risk room air severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia suppress UD group Usual dose with COVID-19 [DOI] 10.1186/s12879-021-06119-2 PMC 바로가기 [Article Type] Clinical Trial
Survival Analysis of Patients With COVID-19 in India by Demographic Factors: Quantitative StudyOriginal Paper Published on 2021-05-062022-10-30 Journal: JMIR Formative Research [Category] COVID-19, [키워드] 95% CI age age and sex Analysis COVID-19 COVID-19 case critical appraisal death declined demographic female patient functions Government group groups hazard model hazard ratio higher risk Identifier identify increasing age India Kaplan-Meier lockdown log rank test male modeling Mortality National North objective pandemic disease Patient patient data patients patients with COVID-19 positive probability of survival Region report reported Result risk Sex Significant study period surpassed survival survival analysis survival rate survivorship the disease Transmission Transmission dynamics Variability were used Wilcoxon test [DOI] 10.2196/23251 PMC 바로가기 [Article Type] Original Paper
Rapid development of neutralizing and diagnostic SARS-COV-2 mouse monoclonal antibodies중화 및 진단용 SARS-COV-2 마우스 단일클론항체의 신속한 개발Article Published on 2021-05-062022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] accelerated Amino acid angiotensin angiotensin converting enzyme Applied immunology binding cell types correlated COVID-19 pandemic Critical diagnostic enzyme epithelial cells Epitopes functional functions hACE2 immunization immunohistochemical staining immunology Infectious diseases Interaction Lung epithelial cells lung tissue mAb mAbs monoclonal antibody mouse monoclonal antibody Neutralizing Protein Rapid RBD reagent receptor Receptor binding domain Research S1 subunit SARS-CoV-2 screening process sequence Spike protein staining the S1 subunit the spike protein therapeutic Viral viral neutralization [DOI] 10.1038/s41598-021-88809-0 PMC 바로가기 [Article Type] Article
Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?번역 모델로서의 Zebrafish: 후각 상실과 COVID-19의 가능한 신경퇴행성 측면과 관련된 메커니즘을 연구하기 위한 실험적 대안?Review Published on 2021-05-052022-09-10 Journal: eNeuro [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Anosmia aspect Asymptomatic Brain classical Clinical symptoms Cohort cohort of patients conditions coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Danio Effect embryonic embryonic development Encephalitis feature functions Genetic genetic manipulation high availability induce investigated Logistic long-lasting mammalian mechanism neurodegeneration neurologic neurologic disorders neuroscience olfactory Olfactory system organism pandemic pathway Preclinical replications respiratory respiratory manifestations SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity suggested Symptom Treatment Variability Visual with COVID-19 zebrafish [DOI] 10.1523/ENEURO.0027-21.2021 PMC 바로가기 [Article Type] Review
Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current DataMedicine Published on 2021-05-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] articles case-control studies Chronic fatigue COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 symptom COVID-19 symptoms criteria cross-sectional current database Evidence functions Google Scholar Health heterogeneity initial search long-term sequalae long-term symptoms lung neurologic olfactory Pain Patient persistent persistent symptoms proportion public health reported reporting symptom respond review SARS-COV-2 infection screened second wave Stage suffered Symptom Symptoms systematic review virus Web of Science widespread [DOI] 10.3389/fmed.2021.653516 PMC 바로가기 [Article Type] Medicine
The Anti-Infectious Role of Sphingosine in Microbial DiseasesReview Published on 2021-05-042022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acute respiratory syndrome airway epithelial cell Bacteria Bacterial Bacterial infections bacterial pathogen Cancer Cell cellular ceramide cholesterol component Coronavirus-2 death Defense Diseases fibrosis functions fungal pathogens fungi herpes simplex host cell receptor HSV-1 Infection Inflammation inhibit involved kill macrophages membrane metabolite microbes normalized organized Pathogenesis Prevent promote recent reduced released respiratory tract role SARS-CoV-2 shown signaling molecule sphingolipid sphingolipids sphingosine sphingosine kinases sphingosine-1-phosphate subsequent viral infection viral spike protein virus viruses [DOI] 10.3390/cells10051105 PMC 바로가기 [Article Type] Review
End of Life Intervention Program During COVID-19 in Vall d’Hebron University HospitalPsychiatry Published on 2021-05-032022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] activated Care Complication condition consequence coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient criteria death Descriptive analysis diagnosed with COVID-19 emotional End End of life example Factor feature functions grief Health Healthcare system Hebron hospital Hospitalized Intervention intervention program life material measure mental health mitigate mourning Pathologies Patient patients PGD predict Prevent Program Prolonged prolonged grief disorder Psychological psychologist reported required social distancing the patient university [DOI] 10.3389/fpsyt.2021.608973 PMC 바로가기 [Article Type] Psychiatry
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software