Increased frequency of porcine epidemic diarrhea virus shedding and lesions in suckling pigs compared to nursery pigs and protective immunity in nursery pigs after homologous re-challengeResearch Article Published on 2016-11-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] age assigned cause Clinical sign Course disease epidemic diarrhea euthanized fecal Frequency group groups homologous IgA antibody IgG level Increased Infection initial lesion less naïve PEDV pig populations protective immunity Randomly RNA seroconverted Spread the disease Typical virus while [DOI] 10.1186/s13567-016-0402-5 PMC 바로가기 [Article Type] Research Article
Transcription Factors Encoded on Core and Accessory Chromosomes of Fusarium oxysporum Induce Expression of Effector GenesFusarium oxysporum의 코어 및 액세서리 염색체에 인코딩된 전사 인자는 이펙터 유전자의 발현을 유도합니다Research Article Published on 2016-11-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accessory accessory chromosome accessory chromosomes activate autonomous bind binding site chromatin chromatin condensation chromosome chromosomes colonisation connection conserved constitutive promoter core core genome determine DNA binding effector effectors ENCODE Evolution example expression extreme facilitate Factor FTF1 FTF2 fungal fungi Fusarium GC content Gene Expression Genes Genome genomic genomic region homolog homolog FTF2 homologous Host independent induce Infection Interaction investigated maintain motif motifs nine occurred oligonucleotide oligonucleotide arrays outcome overlapping pathogen Pathogenesis pathogenic pathogenicity Pathogens predicted promoters reference strain Region required RNAseq analysis secreted Sge1 specificity strain Strains tomato Transcription transcription factor transcription factor gene transcription factor genes transcription factors transcriptional transcriptionally transfer transferred transposon up-regulated virulence yeast [DOI] 10.1371/journal.pgen.1006401 PMC 바로가기 [Article Type] Research Article
Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets against homologous challengeResearch Published on 2016-04-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute diarrhea aligned Amino acid Analysis antigenic antigenicity caused China classical colostrum Complete control vaccine Critical demonstrated diarrhea effective Efficiency Epidemic epidemic diarrhea Epidemic strain Evidence genomic sequence homologous identity immune Immune protective efficiency immunized inactivated indicate insertion intestinal isolate Isolation neutralizing antibody Neutralizing antibody titer nucleotide nucleotide deletion nucleotide sequence occurred outbreak pathogenic PEDV Porcine epidemic diarrhea virus PROTECT Protective Result S gene sequence sera significantly higher Strains Symptom Vaccine variants Variation virulent virus [DOI] 10.1186/s12985-016-0529-z PMC 바로가기 [Article Type] Research
Genomic Analysis and Surveillance of the Coronavirus Dominant in Ducks in ChinaResearch Article Published on 2015-06-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] cellular China circulating conserved coronavirus deletions demonstrated distribution dominant duck ecological niches Evolution frameshift genetic diversity Genome homologous insertions Lineage occurred Organisms performed prevalent Protein recombination event Region RNA viruses RT-PCR assay sequenced substitutions Surveillance viral genome [DOI] 10.1371/journal.pone.0129256 PMC 바로가기 [Article Type] Research Article
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigsResearch Article Published on 2015-05-062022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] antibody clinical Contact Day demonstrated disease effective Endemic epidemic diarrhea evaluate homologous immune response Infection Infectious virus information initial naïve PCR PCR-negative PCR-positive PEDV pig positive Primary infection protective immunity Re-infection repeated RNA S1 and S2 selected seroconverted Transmission Vaccine virus virus transmission was determined [DOI] 10.1186/s13567-015-0180-5 PMC 바로가기 [Article Type] Research Article
The Nucleocapsid Protein of Human Coronavirus NL63Research Article Published on 2015-02-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis binding C-terminal domain Cell cell cycle progression cellular processes Characteristics Coronaviral coronavirus described disease expressing feature Genetic genomes HCoV-229E HCoV-NL63 homologous Human human coronavirus human coronavirus 229E infected cells involved N-terminal domain NL63 nucleic acid nucleocapsid protein nucleus oligomerization other coronaviruses pathogen Protein respiratory tract responsible reveal SARS-CoV severity subcellular localization the N protein transfected cells unique viral replication [DOI] 10.1371/journal.pone.0117833 PMC 바로가기 [Article Type] Research Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 SerotypeResearch Article Published on 2011-08-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence backbone Belonging Clinical sign Clinical signs defined different ectodomain effective expressing Genetic Heterologous homologous IBV Infected M41 observation pathogenic pathogenicity qRT-PCR recombinant removed RNA S gene serotype shown spike the S protein the spike protein Trachea Vaccines virus wild type [DOI] 10.1371/journal.pone.0024352 PMC 바로가기 [Article Type] Research Article
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus VaccinesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antigen-presenting cell Author Cell culture Cell-mediated immunity cellular Cellular immune response coding sequence coronavirus Coronavirus infection coronavirus vaccine Coronavirus vaccines Coronaviruses Culture deleting dendritic cell disease elicited Factors Gene Expression genetics Heterologous homolog homologous IFN immune responses implication in vitro in vivo interfere long-lasting low dose macrophages Major MHV mice mouse hepatitis virus murine model mutant mutant virus non-structural protein pathogenicity plasmacytoid dendritic cells prevention Protective protective immune response Protein provide recombinant vaccine reduced replicate Replication replication-competent virus restored retained SARS-coronavirus sequence Spread T cell response tissue Type I IFN type I interferon vaccination Vaccine viral disease viral pathogenicity viral pathogens virus wild-type [DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article