SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?SARS-CoV-2-토착 미생물총 넥서스: 장내 미생물총이 COVID-19의 염증 및 질병 중증도에 기여합니까?Cellular and Infection Microbiology Published on 2021-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 alteration approach Asymptomatic COVID-19 Cardiovascular disorders Clinical outcome co-morbidities comorbid condition contribute COVID-19 COVID-19 disease disease Dysbiosis effective Gut gut microbiome gut microbiota Host immune responses Immunopathogenesis Inflammation innate immune response Microbiome Microbiota (microorganism) morbidities novel obesity prebiotics prediction Probiotics profile SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection symptomatic T2D targeted intervention targeted interventions Therapeutic approach Therapeutic strategies [DOI] 10.3389/fcimb.2021.590874 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링Review Published on 2021-02-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus [DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection초기 비인두 감염에서 SARS-CoV-2 선천적 이펙터 연관성 및 바이러스 부하Observational Study Published on 2021-02-242022-09-01 Journal: Physiological Reports [Category] MERS, 임상, 진단, [키워드] 95% CI ACE age ambulatory Antiviral antiviral gene antiviral protein antiviral responses applied association Biomarkers blocked BST cause Chain Reaction change characterized clinical outcomes clinical testing COVID‐19 cytokine Cytokines discrepancy disease disrupt early disease Effects elevated Evidence evidence of examined Host host shut‐off Hypothesis IFIT1 IFIT3 IFN IFN‐γ immune immune responses immunoassays individual Infection Inflammatory cytokines innate immune innate immune response innate immune responses Innate immunity interferon interferons ISG Modification multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Older age outcomes Patient polymerase chain polymerase chain reaction polymerase chain reaction assays Proinflammatory cytokine Protein proteomics Quantitative responses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease subsequent Symptom symptomatic patient systemic inflammatory tested transcribed transcript Transcription transcripts translated translation university Utah Viral viral infection Viral load widespread with infection [DOI] 10.14814/phy2.14761 PMC 바로가기 [Article Type] Observational Study
Low compositions of human toll-like receptor 7/8-stimulating RNA motifs in the MERS-CoV, SARS-CoV and SARS-CoV-2 genomes imply a substantial ability to evade human innate immunityBioinformatics Published on 2021-02-242022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] bats comparison computational method coronavirus coronavirus genomes Coronaviruses Defense evade evaluate exhibited Genome genomic genomic RNA hosts Immunostimulating RNA motifs innate immune response innate immune system Innate immunity Logistic regression mammalian MERS-CoV motif pathway positive prediction receptor Result RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 genome single-stranded RNA virus Single-stranded RNA viruses Surveillance the interferon TLR Toll-like receptor Toll-like receptor 7/8 trimer was used [DOI] 10.7717/peerj.11008 PMC 바로가기 [Article Type] Bioinformatics
Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children소아에서 SARS-CoV-2 감염의 급성 및 회복기 동안의 타고난 세포 프로필Article Published on 2021-02-172022-09-10 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단, [키워드] activated neutrophil Activated neutrophils acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD63 cell profile children circulating classical clinically convalescent convalescent phase coronavirus Course COVID-19 dendritic cell dendritic cells disease immune responses immunological immunological mechanism Immunopathogenesis infected children Infection Infectious diseases Innate innate immune response innate immune system Innate immunity low-density Mild mild SARS-CoV-2 infection monocyte Monocytes natural killer cell Natural killer cells neutrophil Neutrophils non-classical monocyte Non-classical monocytes observé PCR testing proportion reduced respiratory SARS-CoV-2 SARS-COV-2 infection subset [DOI] 10.1038/s41467-021-21414-x PMC 바로가기 [Article Type] Article
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2Tipiracil은 우리딘 부위에 결합하여 SARS-CoV-2의 Nsp15 엔도리보뉴클레아제 NendoU를 억제합니다.Article Published on 2021-02-092022-09-10 Journal: Communications Biology [Category] MERS, 치료제, [키워드] active site addition approved assays bind binding pocket binding site biochemical C-terminal catalytic catalytic domain cleave Colorectal cancer complex conserved Coronaviruses crystal structure crystal structures Crystallography drugs endoribonuclease EndoU enzyme Evidence FDA inhibit innate immune response Interaction Interference ions knowledge manganese mechanism mechanisms Molecular biology Nsp15 nucleotide nucleotides recognize responsible RNAs SARS-CoV-2 SARS-CoV-2 Nsp15 sequence specificity structural biology Structure therapeutic intervention tipiracil transition Treatment uracil uridine [DOI] 10.1038/s42003-021-01735-9 PMC 바로가기 [Article Type] Article
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapyArticle Published on 2021-02-062022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Analysis Biological Biological sciences Calu-3 coronavirus COVID-19 Disease progression elicited epithelial cell line epithelial cells expression gene expression profile Genes Heat shock host responses Hsp90 human cell line human cell lines identify IL-6 impair infected cell infected cells Infection inhibition inhibitor innate immune response interferon interferon regulatory factor knowledge Molecular biology NF-kB nuclear omics primary human airway pro-inflammatory cytokine pro-inflammatory gene Protein reduction RNA sequencing SARS-CoV SARS-CoV-2 subset suggested target gene Temporal therapy transcriptional activity transcriptomics upregulated viral replication Virology virus infection were expressed [DOI] 10.1016/j.isci.2021.102151 PMC 바로가기 [Article Type] Article
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across speciesCoronaviruses Published on 2021-01-292022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] 3CLpro cleavage cleave cleaved cleaving contribute COVID-19 COVID-19 patients Critical cytokine Direct disease ENCODE example explain function Genome homolog Host IFN response implication in-vitro assay inflammatory pathway Inflammatory response innate immune response Innate immunity involved IRF3 lack mediated cleavage molecular mechanism motif NLRP12 NSP3 (PLpro) nsp5 NSP5 (3CLpro) pathophysiology PLPro polyprotein protease Protease activity Protein Replication responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protease TAB1 [DOI] 10.1080/22221751.2020.1870414 PMC 바로가기 [Article Type] Coronaviruses
Structure of Nonstructural Protein 1 from SARS-CoV-2SARS-CoV-2의 비구조 단백질 1의 구조Article Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Antiviral antiviral therapy carboxyl causative agent cellular city clone conformation coronavirus Coronavirus replication CoV COVID-19 COVID-19 pandemic CoVs Critical crystal structure cultured cells Deletion effective vaccine Effective vaccines element facilitate Factor Features flexible function Health high-resolution crystal structure Host host cell infecting inhibit innate immune response life cycle live-attenuated vaccines mechanism molecular mRNA degradation Mutation nonstructural protein 1 Novel coronavirus novel coronaviruses nsp1 Occurrence Pneumonia prevented promote Protein public health recruited respiratory Respiratory illness reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 NSP1 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory illness shown Structure structure-function Support target therapeutic option translation turn underlie Vaccine design Vaccine development Viral viral life cycle virus virus infection Wuhan Wuhan, China X-ray X-ray crystallography [DOI] 10.1128/JVI.02019-20 PMC 바로가기 [Article Type] Article
Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylationReview Published on 2021-01-262022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Activation antagonized Antiviral antiviral responses cellular coronavirus COVID-19 pandemic DNA viruses DUB dysregulation enzyme evade Evidence immune evasion include innate immune response Innate immunity interferon ISG15 knowledge mechanism Pathogenesis pathway post-translational modification Protein regulate Regulation RIG-I-like receptor RLRs RNA virus SARS-CoV-2 Signaling turn type I interferon ubiquitin upregulation Vaccines viral evasion viral pathogen virus infection [DOI] 10.3390/v13020182 PMC 바로가기 [Article Type] Review