Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E)Brief Report Published on 2020-05-172022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] 229E activity Antiviral antiviral activity can be used cells clinical trial Comparative Compound compounds concentrations conjugate Conjugates COVID-19 cytotoxicity determine DNA polymerase EFdA exhibited fibroblast HCoV-229E human coronavirus human coronavirus 229E inactive inhibitor interfere lung cell normal NRTIs nucleoside nucleotide prodrug other coronaviruses parent Remdesivir RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 tested Treatment were used with HIV [DOI] 10.3390/molecules25102343 PMC 바로가기 [Article Type] Brief Report
How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders?Letter to the Editor Published on 2020-05-112022-10-29 Journal: Journal of Applied Oral Science [Category] COVID-19, MERS, SARS, [키워드] Bruxism COVID-19 pandemic Impact interfere temporomandibular [DOI] 10.1590/1678-7757-2020-0263 PMC 바로가기 [Article Type] Letter to the Editor
Modeling the trend of coronavirus disease 2019 and restoration of operational capability of metropolitan medical service in China: a machine learning and mathematical model-based analysisResearch Published on 2020-05-062022-10-31 Journal: Global Health Research and Policy [Category] COVID-19, MERS, [키워드] 95% CI accumulated adopted Analysis ARIMA Asymptomatic Beijing China Combined confirmed cases coronavirus disease country COVID-19 COVID-19 epidemic cumulative death disease Epidemic expected Government Guangzhou Hospitalization interfere Intervention mathematical measure medical need Migration modeling number of infected other disease outbreak Patient predicted professionals recovered Result SEIR Shanghai the epidemic virus carrier was used would increase Wuhan [DOI] 10.1186/s41256-020-00145-4 PMC 바로가기 [Article Type] Research
Digesting the crisis: autophagy and coronavirusesViewpoint Published on 2020-05-042022-10-30 Journal: Microbial Cell [Category] COVID-19, [키워드] antiviral response approach arise autophagic autophagy catabolic cellular homeostasis consequence coronavirus COVID-19 COVID-19 pandemic evade Evidence immune cells Immunity Inflammation inflammatory reactions interfere involved mechanism MERS novel coronavirus SARS-CoV-2 pathway question Replication SARS SARS-CoV-2 target therapeutic interventions viral antigens virophagy virus [DOI] 10.15698/mic2020.05.715 PMC 바로가기 [Article Type] Viewpoint
Hyperglycemia, hydroxychloroquine, and the COVID‐19 pandemicReview Published on 2020-04-272022-10-30 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] abrogate ACE2 acute respiratory distress agent antibody‐mediated cell‐mediated cytotoxicity Antiviral agents appear ARDS blunt Concentration Course COVID‐19 diabetes Diabetes Mellitus disease enzyme explained glycosylated glycosylation Hydroxychloroquine hyperglycemia Inflammatory response interfere lung epithelium Macrophage macrophage polarization mechanism neutralizing antibody overactive pandemic Pathogenesis Protein pulmonary immune response receptor SARS Coronavirus SARS‐CoV‐2 severity Spike protein susceptible patients symptom onset syndrome the disease Viral load viral particle [DOI] 10.1002/jmv.25887 PMC 바로가기 [Article Type] Review
Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19Review Published on 2020-04-262022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome agency antiviral drug antiviral drugs can be used carrier caused Chinese chloroquine/hydroxychloroquine confirmed case contribute coronavirus coronavirus disease Coronavirus-2 Coronaviruses COVID-19 Critical current death drug drugs effective Efficacy eligible EVs Extracellular vesicles FDA genome sequence Health High dose HIV identity IMPROVE in vitro interfere lack maturation outbreak pandemic Patient Potential potential mechanism progression Protease inhibitor protease inhibitors provide Remdesivir reported repurposing SARS-CoV SARS-CoV-2 sequence identity shown Side effect slow disease systemic side effects therapeutic window treat Treatment unique Vesicle viral replication virus WHO whole-genome World Health Organization [DOI] 10.3390/v12050486 PMC 바로가기 [Article Type] Review
A Review of SARS-CoV-2 and the Ongoing Clinical TrialsReview Published on 2020-04-102022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus 2019-nCoV ACE2 affecting alleviate antibody antimalarial antiviral drug antiviral immune response approach boost categories Characteristics clinical Clinical data Clinical features clinical study clinical trial clinical trials coronavirus COVID-19 COVID-19 pandemic Data analysis disease drugs dysregulated effective endosomal entry pathway epidemiological Epidemiology Favipiravir feature global pandemic Healthcare system high variability Hydroxychloroquine Immunotherapy Inflammatory responses initial initiated interfere MERS-CoV Middle East molecular outbreak pandemic pathology Pneumonia rapid response replicase respiratory syndrome coronavirus review SARS-CoV SARS-CoV-2 tested therapeutic therapeutic agent therapeutic potential Treatment Trial Vaccine viral replication virulent virus virus infection virus replication Wuhan Wuhan, China [DOI] 10.3390/ijms21072657 PMC 바로가기 [Article Type] Review
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors530 Published on 2020-04-072022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, [키워드] activate activating Activation approach caused Cell cells cleave conserved coronavirus Coronaviruses CoV CoVs cytoplasm dampen detect disease Endemic endoribonuclease EndoU evade Express extension facilitate Factor Host immune immune sensing infect infections information inhibiting inhibitor interfere interferon interferon response limit MDA5 mechanism morbidity and mortality Mutation Nsp15 pathogen-associated molecular Pathways pattern recognition receptor positive-sense Prevent previous study reservoir RNA RNA synthesis RNA virus robust sequence Significance stimulate target therapeutic intervention transfecting Viral RNA virus viruses [DOI] 10.1073/pnas.1921485117 PMC 바로가기 [Article Type] 530
Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked PolyubiquitinationImmunology Published on 2019-05-092022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Activation antiviral response binding coronavirus demonstrated diarrhea double-stranded RNA Host host antiviral response IFN-β IFN-β immune Infection infections inhibit inhibiting innate immune response interfere interferon mechanism N protein N-terminal Newborn nucleocapsid nucleocapsid protein outbreak PDCoV porcine RIG-I Production promoter Protein receptor RIG-I signaling molecules stimulated suppressed Surveillance therapeutic target TNF ubiquitination Vaccine vesicular stomatitis virus virus infection Virus-host interaction vomiting VSV [DOI] 10.3389/fimmu.2019.01024 PMC 바로가기 [Article Type] Immunology
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoproteinArticle Published on 2019-04-022022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] antibodies antibody antibody-based therapy binding cause coronavirus Critical develop distinct domain domain epitope function functions group Human Human monoclonal antibody humans humoral interfere membrane fusion MERS MERS-CoV mice neutralizing antibody offer passive immunization Protective Receptor binding Receptor binding domain Respiratory disease respiratory syndrome coronavirus sialic acid spike glycoprotein Spike protein viral spike protein virus zoonotic [DOI] 10.1080/22221751.2019.1597644 PMC 바로가기 [Article Type] Article