Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defenseArticle Published on 2022-03-222023-06-14 Journal: Cell Reports [Category] MERS, SARS, [키워드] endocytosis host defense Influenza interferon ISG proximity labeling RABGAP1L siRNA screening virus restriction VPS33A [DOI] 10.1016/j.celrep.2022.110549 PMC 바로가기 [Article Type] Article
Humoral and cellular immunogenicity of SARS-CoV-2 vaccines in chronic lymphocytic leukemia: a prospective cohort study만성 림프구성 백혈병에서 SARS-CoV-2 백신의 체액 및 세포 면역원성: 전향적 코호트 연구Clinical Trial Published on 2022-03-222022-09-11 Journal: Blood advances [Category] MERS, SARS, 변종, 임상, 진단, [키워드] Absolute lymphocyte count accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody Response Antibody responses assays bead-based multiplex immunoassay binding cellular characterization chronic chronic lymphocytic leukemia clinical benefit CLL CLL patient Cohort coronavirus COVID-19 mortality demonstrated develop dose elicited framework function functional IgG immunoassay induce interferon interferon-γ leukemia lymphocyte Lymphocytic leukemia molecular mechanism molecular mechanisms mRNA-based vaccine outcome Patient Previous studies previous study prospective cohort study provide RBD Receptor binding domain Registered respiratory response rate responses SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine Serologic response serologic responses severe acute respiratory syndrome Coronavirus Spike-specific T-cell responses T-cell T-cell Response T-cell responses tested Therapies therapy treatment-naïve patient treatment-naïve patients Trial vaccination Vaccine variant was performed wild-type [DOI] 10.1182/bloodadvances.2021006627 PMC 바로가기 [Article Type] Clinical Trial
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells Research Published on 2022-03-172022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute SARS-CoV-2 infection Analysis Autoimmunity Cancer Cancer therapy expression feature Genes IFN-I IFN-I response Immunotherapy in vitro Infectious disease inhibiting interferon LAG-3 mechanism mRNA Perturbation receptor regulate regulatory network SP140 T cell T cells target TFS TIGIT transcription factor transcriptional Type type 1 interferon unique [DOI] 10.1038/s41590-022-01152-y [Article Type] Research
Specialized interferon action in COVID-19코로나19에 특화된 인터페론 작용Article Published on 2022-03-152022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘, 진단, [키워드] Activation Antiviral association C-reactive protein cell types circulating clinical marker clinical markers COVID-19 COVID-19 pathology CyTOF cytokine diagnostic disease severity Effect endothelial damage example Hospitalization hospitalized COVID-19 patients IFN IFN signaling IFNA2 IFNA6 IFNB1 IFNg IFNs Immune cell immune cell types immune cells immune marker Impact Implications interferon Kynurenine Kynurenine pathway lymphocyte lymphoid marker neutrophil pathology platelet activation poor prognosis Protective proteomics SARS-CoV-2 Seroconversion severe disease Signaling significant decrease subset the strongest therapeutic transcriptional response type I unique [DOI] 10.1073/pnas.2116730119 PMC 바로가기 [Article Type] Article
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine Research Published on 2022-03-142022-10-05 Journal: Nature Immunology [Category] 치료제, [키워드] adaptive analyzed antibody BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine CD8+ T cell cell death pathways circulating dependent on draining lymph node Efficacy IFN-γ immune responses Immunity immunization immunological mechanism inflammasome activation innate response interferon knockout mice MDA5 mice molecular mechanism natural killer cell necroptosis Pfizer-BioNTech pyroptosis response serum Signaling stimulate stimulated T cell response T cell responses Toll-like receptor type I underlie [DOI] 10.1038/s41590-022-01163-9 [Article Type] Research
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim BladderCOVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성Article Published on 2022-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, [키워드] abortive infection animal animal model animal models Bath bladder wall bloodstream Brain Cell comparable COVID-19 decrease drug Embryo epithelial cell epithelial cells Evidence evidence of Host human ACE2 immunohistochemistry in some in vitro Infection inoculated interferon lung mammalian microinjection no evidence of organ overexpression pathophysiology Prophylactic SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA several variant several variants similarity swim bladder tested therapeutic type I type I interferon Viral load Viral RNA virus wild-type zebrafish [DOI] 10.3389/fcimb.2022.790851 PMC 바로가기 [Article Type] Article
Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19항바이러스 대사 산물 3'-deoxy-3',4'-didehydro-cytidine은 혈청에서 검출 가능하며 COVID-19를 포함한 급성 바이러스 감염 식별Article Published on 2022-03-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute viral infection Admission an area Antiviral AUC Bacterial Bacterial infection Bacterial infections Biomarker characteristic CMPK2 Cohort correlated COVID-19 Critical cytidine ddhC detectable Diagnosis diagnostic diagnostics emergency department enzyme Enzymes examined FIVE Gene Expression healthy controls High-resolution highlight identify implicated in viral in vivo independent inflammatory conditions interferon Liquid chromatography management marker mass spectrometry metabolite metabolome metabolomics NIHR pandemic Patient precursor Profiling receiver operating characteristic receiver operating characteristic curve responsible sera serum significantly small molecule Support transcripts validation cohort viperin Viral viral infection viral infections [DOI] 10.1016/j.medj.2022.01.009 PMC 바로가기 [Article Type] Article
SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity특정 체액 면역이 없는 1차 항체 결핍 환자의 중증 및 치명적인 COVID-19에서 SARS-CoV-2 T 세포 반응Article Published on 2022-03-102022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis analyzed antibody autoantibodies autoantibody Blood CD169 CD4 cellular characterized clearance clinical disease Comorbidities Comorbidity convalescent convalescent plasma Convalescent plasma (CP) coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 cytokine deficiency detectable elevated examined excluded expression fatal COVID-19 flow cytometry healthy individuals heterogeneous humoral humoral immune response IgG Immunity immunodeficiency immunological immunological mechanism Inborn errors indicate innate immune response Innate immunity interferon interferons lack marker median monoclonal antibody Monocytes morbidity Mortality mucosal naïve nucleocapsid outcome Patient patients peptide peptide pool Peripheral blood persistence phenotype primary antibody primary antibody deficiency (PAD) Primary immunodeficiencies primary immunodeficiencies (PID) producing Prophylactic respiratory response Risk factors robust SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 viral shedding seronegative severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severe case severe cases severe COVID-19 patient SIGLEC1 Specific T cell T cell response T cells Treatment type I interferon type I interferon response type I interferons undetectable Viral viral clearance viral shedding with COVID-19 [DOI] 10.3389/fimmu.2022.840126 PMC 바로가기 [Article Type] Article
Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial CellsArticle Published on 2022-03-092023-07-01 Journal: Journal of Virology [Category] COVID19(2023년), SARS, [키워드] human intestinal epithelial cells interferon Interferon lambda intrinsic immune response SARS-CoV-2 type III interferon [DOI] 10.1128/jvi.01705-21 PMC 바로가기
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathwayArticle Published on 2022-03-082023-07-08 Journal: Immunity [Category] COVID19(2023년), [키워드] Apoptosis BAX and BAK caspase-8 COVID-19 hemophagocytic lymphohistiocytosis iNOS interferon SARS-CoV-2 TNF Toll-like receptor [DOI] 10.1016/j.immuni.2022.01.003 PMC 바로가기