Case Report: Interferon-γ Restores Monocytic Human Leukocyte Antigen Receptor (mHLA-DR) in Severe COVID-19 With Acquired Immunosuppression SyndromeImmunology Published on 2021-04-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Acquired acquired immunosuppression syndrome acute respiratory distress acute respiratory distress syndrome Adaptive immune response Antigen ARDS Case report CD14+ characterized circulating monocyte clinical effectiveness COVID-19 COVID-19 patient disease expression high risk histocompatibility complex HLA-DR Human IFN immune increase in induce Infection Infectious disease injection intensive care interferon-y leukocyte MHC mHLA-DR monocyte monocytic human leukocyte antigen receptor observation rapid increase receptor reduced reduction in responsible Safe SARS-CoV-2 Secondary infection secondary infections septic patient severe COVID-19 patient syndrome therapy Tolerance treated unique [DOI] 10.3389/fimmu.2021.645124 PMC 바로가기 [Article Type] Immunology
Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells내피 전구체의 다차원 단백질체 접근은 CD19 세포로 제한된 KDR의 발현을 보여줍니다Clinical Trial Published on 2021-04-012022-08-31 Journal: Stem cell reviews and reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] absence Abstract approach artificial heart B-lymphocyte B-lymphocytes Bioprosthetic total artificial heart Blood C-kit cadherin candidate cardiovascular disease cardiovascular diseases CD133 CD14 CD19 CD34 CD45 Cell cell population cells cellular circulating circulation classic complementary Cord blood COVID-19 COVID-19 severity Critical critical COVID-19 patient cytometric Cytometry demonstrated described Elimination endothelial Endothelial progenitor cell Endothelial progenitor cells Endothelial progenitors evaluate events expresse expressed expressing expression Flow flow cytometry healthy imaging immature induce involved KDR lead Lineage Lymphocytes marker moderate monocyte Monocytes multidimensional one patient Patient performed Peripheral blood phenotype Population positive cell progenitor progenitor cell progenitor cells proteomic quantified redistribution Restricted Single Cell STEM stem cell stem cells subpopulation subset Subtypes vasculogenesis VE-cadherin VEGFR-2/KDR. [DOI] 10.1007/s12015-020-10062-1 PMC 바로가기 [Article Type] Clinical Trial
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protectionSARS-CoV-2에 대한 인간 중화 항체는 최적의 치료 보호를 위해 온전한 Fc 효과기 기능을 필요로 합니다Article Published on 2021-04-012022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Administered antibody benefit caused CD8 CD8+ CD8+ T cells Cell clinical trials COVID-19 pandemic Depletion disease effector function function hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IMPROVE in vivo Infection Inflammation innate immune loss-of-function lung Lung disease Lung infection lung; mAb mAbs mechanism of action mice mitigate monocyte Monocytes mouse model Neutralizing Neutralizing antibodies neutralizing antibody Pathogenesis phenotype preserved Prophylaxis reduce required respiratory Respiratory mechanics RNA RNA sequencing SARS-CoV-2 Signaling T cell T cells therapeutic therapy tissue repair transcriptional variant Virological [DOI] 10.1016/j.cell.2021.02.026 PMC 바로가기 [Article Type] Article
The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positiveResearch Article Published on 2021-03-312022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] 95% CI adjusted analyses Analysis association Chinese COVID-19 COVID-19 patient discharge enrolled estimate evaluated female greater higher risk hospital hypertension increase in increased risk interactions Logistic regression management median age monocyte not significant participant Patient performed positive positive patients prevention Recurrent positive Result risk RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA positive duration stratified supplementary material [DOI] 10.1186/s40249-021-00831-6 PMC 바로가기 [Article Type] Research Article
Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe vs . common diseaseOriginal Paper Published on 2021-03-292022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] accompanied Admission analysed changes in characteristic clinical Clinical characteristics common disease coronavirus disease Course COVID-19 COVID-19 disease severity COVID-19 patient cut-off value Cutoff diagnosed discharged FIVE generate hospitalisation increases in indicated Laboratory lymphocyte Moderate COVID-19 monocyte Neutrophil-to-lymphocyte ratio Neutrophils NLR parameter Patient patients PCT positive correlation procalcitonin relationship SARS-CoV-2 selected sensitivity severe group Severe patient severity severity of COVID-19 significant difference specificity statistically significant Symptoms treated White blood cells [DOI] 10.1017/S0950268821000674 PMC 바로가기 [Article Type] Original Paper
Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki diseaseCOVID-19 관련 소아 다기관 염증 증후군의 면역 병인과 가와사키병의 유사점 및 차이점Comparative Study Published on 2021-03-152022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, 치료기술, [키워드] Activation chemokines children circulating circulating cytokine circulating cytokines COVID COVID-19 cytokine cytokine profile Cytokines described discriminant analysis elevated evaluated explain GM-CSF group HCs healthy control IFN-γ IL-18 IL-1ra IL-1α immune complex Immune complexes immunology Immunopathogenesis immunopathology Inflammation Inflammatory inflammatory monocyte IP-10 Kawasaki disease Linear Discriminant Analysis Macrophage macrophage activation syndrome management marker MCP-1 MIS-C monocyte overlapping pandemic Pathogenesis Patient patients PCR pediatric plasma sample plasma samples positive profile quantified RANTES SARS-CoV-2 SARS-CoV-2 pandemic SDF-1 serum significantly syndrome the SARS-CoV-2 therapeutic Trigger triggers unique Vasculitis [DOI] 10.1172/JCI144554 PMC 바로가기 [Article Type] Comparative Study
T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19T 세포 활성화, 고도로 무장된 세포독성 세포 및 단핵구 CD300 수용체 발현의 변화는 중증 COVID-19 환자의 특징입니다Comparative Study Published on 2021-03-112022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] activated Activation adaptive alteration Analysis analyzed association CD300a CD300c CD300e CD4 CD8 cells characterized Clinical characteristics clinical phenotype Clinical sign cohort of patient correlated Correlation analysis COVID-19 cytotoxic described double negative expression expression pattern flow cytometric study follicular granzyme B help HLA-DR host immune responses immature Immune cell immune system Immunopathogenesis infected with SARS-CoV-2 Laboratory low expression Mild moderate monocyte Monocytes NK cell NK cells Patient patients performed receptors severe COVID-19 severe disease severity shift T cell subset T cells [DOI] 10.3389/fimmu.2021.655934 PMC 바로가기 [Article Type] Comparative Study
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of deathCOVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다Research Article Published on 2021-03-112022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues [DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severityCOVID-19 중증도의 바이오마커로서 순환하는 골수 세포의 이종 NLRP3 인플라마좀 시그니처Article Published on 2021-03-092022-09-11 Journal: Blood advances [Category] SARS, 바이오마커, [키워드] Activation acute respiratory syndrome Biomarker Blood caspase caspase-1 CD66b Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patients dysregulated immune response eosinophil eosinophils Evolution granulocyte Granulocytes healthy donor healthy donors immature neutrophil immune response Infection Innate immunity key factor Mild monocyte Monocytes myeloid cell myeloid cells Neutrophils nigericin NLRP3 NLRP3 inflammasome outcome pathogen pathogen-associated molecular Patient predict proportion Registered respiratory restored severe acute respiratory syndrome Coronavirus Trial [DOI] 10.1182/bloodadvances.2020003918 PMC 바로가기 [Article Type] Article
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populationsMycobacterium tuberculosis 감염에 대한 내성에 대한 게놈 차원의 연관성 연구는 3개의 별개 집단에서 10q26.2의 유전자좌를 확인합니다Research Article Published on 2021-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95%CI activating ADAM12 allele Analysis association C10orf90 characterized chromosome Cluster Cohort Contact decreased expression defined Diagnosis ENCODE Endemic enrolled epidemiological Evidence exposure to France French Genome-wide association study genome-wide significant genotyped household contact household contacts identify IFN-γ independent individual infected individual infected individuals Infection inter-individual interferon Interferon-gamma intronic region lead locus Lymphocytes monocyte Monocytes Mycobacterium tuberculosis natural history outcome p53 patients performed Population populations positive proportion Protective Release replicated selected shown skin Skin test South Africa subject Suppressor gene Test Th17 transcription factor TST Tuberculin tuberculin skin test Tuberculosis Tumor tumor suppressor tumor suppressor gene ubiquitin ligase upstream Variability variant variants [DOI] 10.1371/journal.pgen.1009392 PMC 바로가기 [Article Type] Research Article