Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine RecipientsBNT162b2 또는 CoronaVac 백신 수혜자의 혈청에 의한 중증 급성 호흡기 증후군 코로나바이러스 2 오미크론 변이체의 중화Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Beta Beta variant beta variants BNT162b2 CoronaVac coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta variants detectable Effectiveness elicited evade genome sequence geometric geometric mean GISAID database GMT GMTs Health Organization isolate Lineage Live virus microneutralization Mutation Nanopore nanopore sequencing neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer no significant difference not affect of BNT162b2 omicron Omicron variant Patient recipient recipients respiratory risk Risk assessment SARS-CoV-2 Sequencing sera severe acute respiratory syndrome Coronavirus significant difference significantly lower spike mutation strain Strains susceptibility TMPRSS2 Vaccine Vaccines variant variant of concern VeroE6 cells virus was determined whole genome sequence World Health Organization [DOI] 10.1093/cid/ciab1041 PMC 바로가기 [Article Type] Article
Rapid Detection and Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Variant in a Returning Traveler귀국 여행자의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 오미크론 변이체의 신속한 감지 및 특성화Case Reports Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Chain Reaction characterization clinical care Community coronavirus coronavirus 2 detection genomic Genomic surveillance Mild symptom mild symptoms multiplex Multiplex PCR occurred omicron Omicron variant polymerase chain polymerase chain reaction polymorphism Rapid respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus single-nucleotide single-nucleotide polymorphism Surveillance Vaccine variant Viral genome sequencing [DOI] 10.1093/cid/ciac032 PMC 바로가기 [Article Type] Case Reports
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernRBD 및 S2를 표적으로 하는 이중특이성 항체는 SARS-CoV-2 오미크론 및 우려되는 기타 변이체를 잠재적으로 중화합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding bispecific antibodies breadth Breakthrough infection caused concern contagious coronavirus country COVID-19 COVID-19 vaccines Delta demonstrated domain dominant effective Efficacy epitope Epitopes feasible highlighting IMPROVE mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant Omicron variants Other other variant other variants parental Prevent Pseudotyped virus RBD Receptor-binding domain reduced respiratory retained SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 WT specificity Spike protein target targeting tested the spike protein therapeutic treat Vaccine variant variants variants of concern VoC VOCs wild-type [DOI] 10.1128/jvi.00775-22 PMC 바로가기 [Article Type] Article
Facing the Omicron variant-how well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic reviewArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] 95% CI acute respiratory syndrome Against approved booster booster dose booster vaccination characterized coronavirus coronavirus disease COVID-19 COVID-19 vaccine Critical death dominant variant Effectiveness estimate European evaluated Evidence Hospitalization ICU admission Immunity immunization indicated Infection interim analysis long-lasting Mild moderate omicron Omicron variant outcomes Participants performed PROTECT ranged receiving remained risk of bia robust SARS-CoV-2 SARS-COV-2 infection searched severe COVID-19 study heterogeneity symptomatic systematic review the SARS-CoV-2 union vaccination Vaccine vaccine effectiveness variant variant of concern website [DOI] 10.3389/fimmu.2022.940562 PMC 바로가기
Fair Allocation of Scarce Therapies for Coronavirus Disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에 대한 희소한 치료제의 공정한 할당Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] ad hoc allocation antiviral drug antiviral drugs antivirals approach asked bioethics category Clinical risk factors Community coronavirus disease Coronavirus disease 2019 COVID-19 delta variant disease doses drug Emergency use authorization EUA exclusion Factor Fair FDA food Government group Health health inequities healthcare identify Immunocompromise Inclusion individual mAbs Mild moderate molnupiravir monoclonal monoclonal antibodies monoclonal antibody Older age omicron Omicron variant Patient Paxlovid Postexposure Prophylaxis rationing required scarcity supply Therapies therapy US Food and Drug Administration vaccination variant [DOI] 10.1093/cid/ciab1039 PMC 바로가기 [Article Type] Article
Coronavirus Disease 2019 Disease Severity in Children Infected With the Omicron Variant코로나바이러스 질병 2019 오미크론 변이체에 감염된 어린이의 질병 심각도Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted odds ratio Admission age children Control coronavirus Coronavirus 2019 COVID-19 death Delta delta variant determined by Diagnosis disease disease severity Hospital admission Hospitalization ICU ICU care Infection intensive care intensive care unit less mechanical ventilation Mild moderate omicron Omicron variant outcome outcomes Primary outcome Propensity score SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly lower variant [DOI] 10.1093/cid/ciac275 PMC 바로가기 [Article Type] Article
Necessity of Coronavirus Disease 2019 (COVID-19) Vaccination in Persons Who Have Already Had COVID-19이미 COVID-19에 걸린 사람에 대한 코로나바이러스 질병 2019(COVID-19) 예방 접종의 필요성Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% CI Cleveland clinic coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination Cox proportional hazard cumulative incidence demonstrated employee evaluate examined group groups Hospitalization hospitalizations Immunity incidence infected individual Infection lower risk mRNA vaccine multivariable Not demonstrated omicron Omicron variant Person positive provide receiving remained risk risk of COVID-19 SARS-CoV-2 second dose significantly lower subjects symptomatic symptomatic COVID-19 tested uninfected vaccination Vaccines variant [DOI] 10.1093/cid/ciac022 PMC 바로가기 [Article Type] Article
High Asymptomatic Carriage With the Omicron Variant in South Africa남아프리카 공화국의 오미크론 변종을 사용한 높은 무증상 캐리지Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic asymptomatic carriage. carriage CD4 Chain Reaction clinical trial coronavirus correlated enrolled HIV Human immunodeficiency virus immunodeficiency virus omicron Omicron variant participant PCR polymerase chain polymerase chain reaction positive PWH SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 polymerase chain reaction South South Africa T-cell Trial [DOI] 10.1093/cid/ciac237 PMC 바로가기 [Article Type] Article
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2SARS-CoV와 SARS-CoV-2 사이의 다양한 보존된 에피토프를 표적으로 하는 항체의 중화 폭Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody therapeutics Beta Beta variant breadth broad neutralizing antibody Candidates class complex conserved conversed epitopes COVID-19 cross-neutralizing antibody cryo Cryo-electron microscopy defined Delta effective electron microscopy epitope Epitopes evade exhibited hamsters immunization Infection Microscopy NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody offer omicron Omicron variant Omicron variants pseudoviruses Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody Spike proteins Structure the receptor-binding domain the spike protein Treatment treatment of COVID-19 Vaccine variant variants variants of concern variants of SARS-CoV-2 Viral [DOI] 10.1073/pnas.2204256119 PMC 바로가기 [Article Type] Article