Respiratory distress syndrome – Page 27 – Communicable Diseases Research

Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Observational Study

Published on 2020-11-012023-07-12
Journal: Clinical microbiology and infection : the official [Category] SARS,

TOCIVID-19 – A multicenter study on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia. Study protocol

TOCIVID-19 - COVID-19 폐렴 환자 치료에서 토실리주맙의 효능 및 내약성에 대한 다기관 연구. 연구 프로토콜

Article

Published on 2020-11-012022-09-11
Journal: Contemporary clinical trials [Category] MERS, 임상, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome administration ambient Analysis can not co-primary endpoints Cohort complication of COVID-19 COVID-19 COVID-19 pneumonia Critical cytokine Cytokine storm dose Efficacy eligible enrolled EudraCT hospitalized patient hospitalized patients Host immune response humanized monoclonal antibody IL-6 IL-6 receptor include intravenous Intravenous administration Intubated Italian population lethality rate lethality rates multicenter multicentre NCT04317092 oxygen oxygen saturation Patient patients patients with COVID-19 Phase 2 Phase 2 study Pneumonia primary analysis prospective cohort protocol reached receive receptor recombinant humanized monoclonal antibody Registered respiratory respiratory distress Respiratory distress syndrome respiratory impairment Respiratory Support Result Sample Sample size single-arm phase 2 single-arm phase 2 study syndrome the cytokine storm Tocilizumab TOCIVID-19 Tolerability treat Treatment Trial with COVID-19
[DOI] 10.1016/j.cct.2020.106165 PMC 바로가기 [Article Type] Article

Kidney transplant patients with SARS-CoV-2 infection: The Brescia Renal COVID task force experience

SARS-CoV-2 감염 신장 이식 환자: Brescia Renal COVID 태스크포스 경험

Multicenter Study

Published on 2020-11-012022-09-11
Journal: American journal of transplantation : official jou [Category] SARS, 치료제,

[키워드] Acute kidney injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus addition Admission age antiviral drugs ARDS average Azithromycin baseline Brescia C-reactive protein Clinical characteristics clinical research/practice Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 D-dimer death Dexamethasone died disease Dyspnea higher risk Hydroxychloroquine Immunosuppression increased risk Infection infection and infectious agents - viral infectious infectious agent infectious agents Infectious disease kidney Kidney disease kidney disease: infectious. kidney transplant lack lymphopenia Methylprednisolone Mild Mild disease Older outcome Outpatient outpatients Patient patients patients with SARS-CoV-2 reduction renal required respiratory respiratory distress Respiratory distress syndrome risk risk factor Risk factors risk of death SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe symptoms syndrome tacrolimus the patient thrombocytopenia Tocilizumab Withdrawal
[DOI] 10.1111/ajt.16176 PMC 바로가기 [Article Type] Multicenter Study

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

COVID-19의 내피 손상 및 혈전성 미세혈관병증: 렉틴 경로 억제제 나르소플리맙으로 치료

Article

Published on 2020-11-012022-09-11
Journal: Immunobiology [Category] SARS, 진단, 치료법,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adverse drug reaction Adverse drug reactions anticoagulant effects ARDS Arterial thrombosis Autopsies baseline bind C-reactive protein C-reactive protein (CRP circulating compassionate use complement Complement activation complications Continuous Positive Airway Pressure control group Coronavirus-2 COVID-19 COVID-19 patient CPAP CRP during treatment effective Endothelial cell endothelial cell damage endothelial damage endothelial injury enzyme human immunoglobulin IgG4 IL-6 IL-8 Immunoglobulin Inflammation inhibit inhibitor Injury interleukin interleukin-6 interleukin-8 intubation Lactate lactate dehydrogenase LDH lectin lectin pathway life-threatening Lung injury mannan MASP-2 monoclonal antibody Mortality Narsoplimab nucleocapsid protein pathogenic Patient positive airway pressure reducing reduction reported respiratory respiratory distress Respiratory distress syndrome resulting retrospective SARS-CoV-2 Serine serine protease serum Serum IL-6 Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome-associated coronavirus-2 significantly higher survived sustained syndrome thrombosis thrombotic thrombotic event Thrombotic events thrombotic risk treat Treatment treatment for COVID-19 was used were assessed were used
[DOI] 10.1016/j.imbio.2020.152001 PMC 바로가기 [Article Type] Article

Pirfenidone: A novel hypothetical treatment for COVID-19

피르페니돈: COVID-19에 대한 새로운 가상 치료제

Article

Published on 2020-11-012022-08-31
Journal: Medical Hypotheses [Category] 신약개발, 유전자 메커니즘, 치료법,

[키워드] ACE acute respiratory distress acute respiratory distress syndrome adverse effects angiotensin angiotensin converting enzyme Angiotensin converting enzyme receptor Apoptosis approved ARDS Cell COVID-19 COVID-19 patients cytokine Cytokine storm decrease distress downregulate expression fibrosis hypothetical idiopathic Idiopathic pulmonary fibrosis Inflammation inhibit Invasion IPF kill majority mechanism mechanism of action Mild mild to moderate mild to moderate disease moderate disease morbidity Mortality multiorgan failure oxidative stress pathophysiology Patient patients with COVID-19 Pirfenidone pneumocyte Pneumocytes PROTECT pulmonary pyridone receptor respiratory distress Respiratory distress syndrome syndrome Treatment treatment for COVID-19 treatment of COVID-19 patients
[DOI] 10.1016/j.mehy.2020.110005 PMC 바로가기 [Article Type] Article

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

뮤신-1 감소 화합물에 대한 고함량 선별 검사를 통해 포스타마티닙을 급성 폐 손상의 신속한 용도 변경 후보로 확인

Article

Published on 2020-10-292022-09-11
Journal: Cell Reports Medicine [Category] 비임상, 신약개발,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ALI approved ARDS breath candidate Cell cell surface clinical development clinical outcomes Compound COVID-19 drug drug candidate Drug repurposing epithelial cells fostamatinib fostamatinib. identify Immune thrombocytopenia inhibitor lung lung epithelial cell Lung epithelial cells Lung injury metabolite mouse model MUC1 mucin pandemic pandemic spread Potential treatment potential treatments predict promote Protein R788 Rapid reduce repurposing respiratory distress Respiratory distress syndrome SARS-CoV-2 Screen spleen Spread Stage SYK syndrome the cell thrombocytopenia Treatment tyrosine
[DOI] 10.1016/j.xcrm.2020.100137 PMC 바로가기 [Article Type] Article

A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

COVID-19 백신 개발의 진행 상황 및 과제 검토

Review

Published on 2020-10-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 신약개발, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting anticipated ARDS AstraZeneca Asymptomatic AZD1222 cause challenge China claimed clinical trial clinical trials CoronaVac coronavirus Coverage COVID-19 COVID-19 pandemic death develop Developing DNA vaccine effective Efficacy effort eight focus global pandemic hygiene immunogenic immunological implication inactivated virus particle vaccine individual Infectious disease International life measure Moderna mRNA-1273 Neutralizing antibodies non-replication viral vector vaccine Novel coronavirus Phase 1 Pneumonia potential limitation potential limitations present Progress PROTECT referred to Repurposed drugs required respiratory respiratory distress Respiratory distress syndrome review RNA vaccine SARS-CoV-2 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus Sinovac social distancing Spread Stage Symptom syndrome Vaccine vaccine candidate vaccine candidates Vaccine development vaccine platform Vaccines vulnerable population Wuhan
[DOI] 10.3389/fimmu.2020.585354 PMC 바로가기 [Article Type] Review

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

SARS-CoV-2 및 ACE2 증강으로 유발된 염증은 심각한 COVID-19의 다발성 장기 부전을 유발합니다: 분자 메커니즘 및 의미

Review

Published on 2020-10-082022-09-10
Journal: Inflammation [Category] MERS, 바이오마커,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggravate Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm Cytokines develop downregulation drive Evidence failure functional high mortality host cell host cells Inflammation Inflammatory responses Injury interleukin interleukin-6 lead Lung injury Macrophage macrophages massive mechanism monocyte Monocytes Multiple multiple organ dysfunction multiple organ dysfunction/failure multiple organ failure Necrosis NFκB nuclear Occurrence organ dysfunction organs pandemic pathological change pathological changes patients of COVID-19 receptor released Renin renin-angiotensin system replicate respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe patients Severe patients of COVID-19 Spike protein syndrome TNFα Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha widespread
[DOI] 10.1007/s10753-020-01337-3 PMC 바로가기 [Article Type] Review

Desperate Times, Desperate Measures: The Case for RRx-001 in the Treatment of COVID-19

절박한 시간, 절박한 조치: COVID-19 치료에서 RRx-001 사례

Article

Published on 2020-10-012022-09-11
Journal: Seminars in oncology [Category] SARS, 신약개발,

[키워드] activate acute respiratory distress acute respiratory distress syndrome acute respiratory symptom acute respiratory symptoms acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approved bosentan Cancer caused Cell chronic obstructive chronic obstructive pulmonary disease clinical clinical trial clinical trials comparable coronavirus Course COVID 19 COVID-19 cytokine Cytokine storm death Deterioration Donor effective evaluated Evidence evidence of expected FDA hypertension Hypothesis ICU immune cascade Infection Inflammatory initiated less lung cancer lung cancer patient Lung infection mechanism of action Mild mild upper respiratory tract infection nitric oxide obstructive pulmonary disease oxidative pandemic Pathogenesis Patient phase phase 3 clinical trial Pneumonia preclinical studies preclinical study prodrome protective effect pulmonary disease pulmonary hypertension Pulmonary infection radiological respiratory respiratory distress Respiratory distress syndrome respiratory tract infection RRx-001 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe pneumonia small molecule smoking syndrome the disease therapeutic activity transfer treat treated Treatment Trial upper respiratory tract upper respiratory tract infection
[DOI] 10.1053/j.seminoncol.2020.07.002 PMC 바로가기 [Article Type] Article

COVID-19 in kidney transplant recipients: A multicenter experience in Istanbul

신장 이식 환자의 COVID-19: 이스탄불의 다기관 경험

Multicenter Study

Published on 2020-10-012022-09-11
Journal: Transplant infectious disease : an official journa [Category] MERS, SARS, 진단, 치료제,

[키워드] acute kidney Acute kidney injury Admission Adult all-cause mortality Analysis Antiviral Antiviral agents average Consensus COVID-19 cyclosporine cyclosporine A cytokine cytokine release Cytokine release syndrome cytokine-targeted therapy diagnosed with COVID-19 distress Dyspnea Fever FIVE Follow-up follow-up period Frequency Hospital stay Immunosuppression include induction Infection intensive care intensive care unit İstanbul kidney kidney transplant kidney transplant recipient kidney transplant recipients Kidney transplantation material mechanical ventilation moderate multicenter pandemic Patient patients patients died Pneumonia primary endpoint recipient reduced Regulation rejection respiratory distress Respiratory distress syndrome retrospective cohort study secondary endpoint Secondary endpoints severe pneumonia significantly higher supportive therapy Symptom syndrome targeted therapy the patient therapy Treatment Turkey
[DOI] 10.1111/tid.13371 PMC 바로가기 [Article Type] Multicenter Study