rheumatoid arthritis

[키워드] affected anti-cytokine antiviral interferon approach Arthritis association bronchoalveolar lavage samples CCL2 CCL3 CD ileum Cell cell-type identification cellular phenotype cellular phenotypes Combination COVID-19 Crohn’s disease CXCL10 CXCL9 Cytokines defined disease-affected donor disease-affected donors disparate Donor driving Effect elevated environmental factor environmental factors established therapy exhibited FIVE GBP1 Genes healthy healthy control healthy subject healthy subjects help human blood-derived macrophage human blood-derived macrophages identify IFN-beta IFN-beta (IFN-β IFN-gamma IFN-β IFN-γ IL1B Immune cell immune cell state immune cell states immune state Immunomodulatory therapies inflamed CD ileum inflamed RA synovium inflamed tissue inflamed tissues Inflammatory inflammatory disease Inflammatory diseases inflammatory factors inflammatory macrophage phenotype Integrative analysis interferon response interferons Interstitial lung disease lung Lung disease lupus erythematosus Macrophage Macrophage heterogeneity macrophage phenotype macrophage phenotypes macrophage state Macrophage stimulation macrophages Meta-analysis mixed-effects modeling Patient patients with COVID-19 pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines protective effect RA synovium Result rheumatoid arthritis severe COVID-19 severe COVID-19-affected lungs single-cell Single-cell multi-disease tissue integration single-cell profile Single-cell transcriptomics SLE Stat1 stimulated Stimulation Support systemic lupus erythematosus tested These cells tissue tissue inflammation tissues TNF TNF-α transcriptomic profile Treatment UC colon ulcerative colitis understanding
[DOI] 10.1186/s13073-021-00881-3 PMC 바로가기 [Article Type] Research