Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19중증 COVID-19에서 키닌-칼리크레인 시스템의 약리학적 억제와 관련된 안전성 및 결과Article Published on 2021-02-162022-09-10 Journal: Viruses [Category] 신약개발, [키워드] accumulation ACE2 angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved Autopsies Autopsy Blood bradykinin case control study catalytic activity Cell cells cellular changes in Clinical improvement Cohort component components Compound Computed tomography coronavirus coronavirus disease coronavirus disease 19 COVID-19 develop Dexamethasone diffusion disease disease severity edema enzyme eosinophils Evidence expressed Hypoxemia Icatibant Inflammation Inflammatory inhibition inhibitor interfere Kallikrein lung lung alveolar marker Mortality Patient pharmacological promoted receptor reduce mortality respiratory Safe Safety SARS-CoV-2 SARS-COV-2 infection severe cases severe COVID-19 severe respiratory syndrome shown System tested Treatment [DOI] 10.3390/v13020309 PMC 바로가기 [Article Type] Article
Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors중증 COVID-19 회복기 기증자로부터 분리된 항체에 의한 다중 클론 SARS-CoV-2 중화Research Article Published on 2021-02-112022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단, [키워드] analyzed anti-SARS-CoV-2 antibodies antibody Antibody Response Antibody responses antigenic antigenic stimulation approaches Author B cell B cell response B cell responses BCR binding site cloned Combination combinations contribute convalescent correlated COVID-19 Culture demonstrated Donor donors effective ELISA epitope Epitopes exhibited feature fusion germline healthy Immune cell immune cells infected cells Infection inhibited Interaction Live virus mAb mAbs majority mapped Mild molecular monoclonal antibody Mutagenesis NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing response Pathogenesis pathogenesis of COVID-19 Patient peptide performed plasma IgG post infection precursor precursors Prevent produced protective immunity RBD receptor Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike Sequencing Severe case severe cases severe COVID-19 severe disease manifestations Severe infection spike Spike receptor binding domain Support syncytia formation the RBD the SARS-CoV-2 the Spike therapy titers of IgG treat two group two groups uninfected unique VH3-53 [DOI] 10.1371/journal.ppat.1009165 PMC 바로가기 [Article Type] Research Article
Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19경증 또는 중증 COVID-19를 가진 여성의 태반 내피에서 혈전 및 미세혈관 손상에 대한 분자적 통찰력Article Published on 2021-02-102022-09-11 Journal: Cells [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus binding cadherin cells chorionic chorionic villus claudin claudin-5 clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decidua decrease Deleterious disease severity endothelial Endothelium expression healthy controls histological analysis immunofluorescence increases in insight Mild Mild disease Placenta placental Placentas pregnant women receptor ACE2 respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 the disease thrombosis variety Vascular VE-cadherin vessels villus von Willebrand factor with COVID-19 with mild disease women [DOI] 10.3390/cells10020364 PMC 바로가기 [Article Type] Article
Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests5가지 SARS-CoV-2 항체 검사의 임상 성능 및 유용성 비교Comparative Study Published on 2021-02-082022-09-10 Journal: PLoS ONE [Category] MERS, 진단, 치료기술, [키워드] both groups comparable COVID-19 antibody COVID-19 patients cut-off Elecsy Elecsys epidemiological studies examined FIVE group immunochromatography in both groups Infection Interpretation Japanese Roche SARS-CoV-2 antibody SARS-CoV-2 antibody test serum sample serum samples severe cases severity specificity two group two groups [DOI] 10.1371/journal.pone.0246536 PMC 바로가기 [Article Type] Comparative Study
Clinical, radiological, and laboratory characteristics and risk factors for severity and mortality of 289 hospitalized COVID-19 patients입원한 코로나19 환자 289명의 중증도 및 사망률에 대한 임상적, 방사선학적, 실험실적 특성과 위험인자Article Published on 2021-02-012022-09-11 Journal: Allergy [Category] MERS, 바이오마커, [키워드] Admission affected age Alanine alanine aminotransferase ALT Analysis analyzed applied aspartate Aspartate aminotransferase AST Blood urea nitrogen C-reactive protein change Chest chest tightness clinical Clinical characteristics clinical manifestation Clinical outcome collected Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 correlation correlations COVID-19 COVID-19 patient COVID-19 patients creatinine CRP CRP level D-dimer death decrease demographics determine discharged Disease progression dynamic Dyspnea elder electronic medical records elevated Eosinopenia Final Follow-up global pandemic groups hospital Hospital stay Hospitalized hospitalized COVID-19 patient In-hospital death independent risk factor independent risk factors investigated Laboratory laboratory characteristics laboratory findings laboratory parameter Laboratory parameters Laboratory test Laboratory tests laboratory-confirmed leukocyte leukocytes lobes longitudinal longitudinal changes lymphocyte lymphopenia male median age medical records Mortality multivariate logistic regression multivariate logistic regression analysis neutrophil neutrophil count Neutrophil-to-lymphocyte ratio nitrogen NLR on admission outcome Patient patients patients died PCA PCT Platelet Platelet count Prevalence Principal component principal component analysis procalcitonin radiological reduce risk risk factor Risk factors separated serum creatinine serum CRP Severe case severe cases severe COVID-19 patients severe patients severity severity of COVID-19 smoking Strong survived sustained the median the patient three groups trajectory urea variable variables were used [DOI] 10.1111/all.14496 PMC 바로가기 [Article Type] Article
[Characteristics and evolution of COVID-19 in an urban Health Center at the pandemic beginning’]Observational Study Published on 2021-02-012022-10-04 Journal: Atencion Primaria [Category] 임상, [키워드] age antibiotic Atención ambulatoria Atención Primaria de Salud average age Care center Coronavirus infections cough COVID-19 diagnosed Diagnosis Dyspnea English Epidemiología Epidemiology evaluate Evolution Features female females Fever Health care worker hospital infecciones por coronavirus Intervention media Mild symptom outcome Outpatient Outpatient Care pandemic Paracetamol Patient patients performed Primary Health Care required Retrospective study Salamanca SAR-CoV-2 SARS-CoV-2 severe cases Spain Spanish tested the patient Treatment Urban health [DOI] 10.1016/j.aprim.2020.10.005 PMC 바로가기 [Article Type] Observational Study
Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assayLuminex 비드 기반 분석을 사용하여 중증 및 경증 COVID-19 사례에서 항체 검출을 위한 표적으로 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 평가Article Published on 2021-02-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody detection Antibody test Antigen assays Bead-based assay Combination coronavirus COVID-19 case domain ELISA Evaluating FIVE IgA antibodies IgA antibody IgA response IgG IgG antibody IgM include Infection Luminex antibody test Mild mild case mild cases multiple antigen multiple antigens Multiplexing neutralization neutralization test neutralizing antibody nucleocapsid nucleocapsid protein offer Pathogens RBD RDTs Receptor-binding domain Recombinant nucleocapsid protein respiratory SARS-CoV-2 SARS-CoV-2 spike sera serological serological test Serological tests Serosurveillance severe cases significantly lower specificity Support symptom onset target threshold titers virus neutralization assays virus neutralization test while [DOI] 10.1016/j.jviromet.2020.114025 PMC 바로가기 [Article Type] Article
Potential mechanisms of cerebrovascular diseases in COVID-19 patientsCOVID-19 환자의 뇌혈관 질환의 잠재적 기전Review Published on 2021-02-012022-09-11 Journal: Journal of Neurovirology [Category] 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affected aggravate Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antiphospholipid antibodies Atherosclerosis attack Blood Blood viscosity cause cerebrovascular Cerebrovascular disease cerebrovascular diseases Clinical practice Coagulation coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infection COVID-19 outbreak COVID-19 patient COVID-19 patients CVD Disruption dysfunction Effect endothelial cells endothelial damage enzyme fibrinolysis followed by greater hemorrhage hypercoagulability hyperglycemia immune Immune complexes immunothrombosis IMPROVE Inflammation inflammatory cascade investigated involved leads mechanism moment neurological neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Occurrence offered outbreak outcome oxidative stress patients plasma Potential potential risk progression promote Psychological Psychological stress Renin renin-angiotensin system respiratory respiratory manifestations resulting risk SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe cases Stress stroke therapeutic thrombosis Treatment Trigger upregulation vascular endothelial cell vascular endothelial cells [DOI] 10.1007/s13365-021-00948-2 PMC 바로가기 [Article Type] Review
COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illnessCOVID-19: 심각한 질병과 관련된 과응고 상태를 촉진하기 위한 과도한 사이토카인 방출 및 잠재적인 ACE2 하향 조절의 역할Review Published on 2021-02-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] 바이오마커, 치료기술, [키워드] ACE2 ACE2 expression activity acute respiratory syndrome addition Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory cytokines association Clinical studies clinical study coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 severity cytokine cytokine release Cytokines down-regulated down-regulation downregulated Effect Elevation enhancement Evidence Excessive cytokine release expression foster hypercoagulable Hypercoagulable state incidence Infectious disease Inflammatory response manifested marker mechanism Novel coronavirus novel coronavirus disease pathogenic mechanism pathogenic mechanisms poor prognosis present prevalent pro-inflammatory pro-thrombotic promote recent reduced respiratory retrospective Serum level serum levels Severe case severe cases severity severity of COVID-19 suggested thrombosis thrombotic thrombotic event Thrombotic events Treatment Vascular vascular thrombosis Vascular thrombotic events. virus with COVID-19 [DOI] 10.1007/s11239-020-02224-2 PMC 바로가기 [Article Type] Review
Venoarteriovenous ECMO in Concomitant Acute Respiratory Distress Syndrome and Cardiomyopathy Associated with COVID-19 InfectionCase Report Published on 2021-01-252022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] ARDS Cardiomyopathy Concomitant COVID-19 COVID-19 infection COVID-19 patient Critically ill database develop ECMO Ejection fraction extracorporeal membrane oxygenation increase in Infection manifested mechanical ventilation medical intervention Mortality Novel coronavirus Patient reduced reported respiratory SARS-CoV-2 severe ARDS severe cases Shock subsequent subset Support with COVID-19 [DOI] 10.1155/2021/8848013 PMC 바로가기 [Article Type] Case Report