The impact of neutralizing monoclonal antibodies on the outcomes of COVID-19 outpatients: A systematic review and meta-analysis of randomized controlled trials중화 단일클론항체가 COVID-19 외래 환자의 결과에 미치는 영향: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] 임상, 진단, [키워드] 95% confidence interval addition adverse event adverse events AEs article clinical Clinical efficacy Cochrane Library control group controlled trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outpatient COVID-19 outpatients database emergency department Health Organization help higher risk Hospitalization ICTRP inception lower risk mAbs Meta-analysis monoclonal mortality rate Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody Odds ratio Odds ratios outcome Outpatient outpatients Patient patients Placebo Primary outcome Randomized controlled trial RCTs reduce registry risk risk of death Safe Safety searched secondary outcome Secondary outcomes serious AE serious AEs significantly lower systematic review the patient Treatment was used Web of Science World Health Organization [DOI] 10.1002/jmv.27623 PMC 바로가기 [Article Type] Meta-Analysis
Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort예방 접종을 받지 않은 코호트에서 SARS-CoV-2에 대한 체액 면역 반응의 유병률, 혈청 전환율 및 수명에 대한 사이토카인 억제제 요법의 영향Article Published on 2022-05-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI adjusted Against age analyzed biologic calculate Care confidence interval Control controls COVID-19 driven by evaluated First wave Follow-up Health humoral immune response IgG antibody IL-17 IL-23 Immune-mediated inflammatory disease Impact inhibitors less Longevity Necrosis not significantly different participant Patient patients treated PCR-positive polymerase chain positive Prevalence prospective cohort Rate receiving reduced Regression response risk RRs SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG antibody SARS-COV-2 infection Seroconversion seroconversion rate seroconvert Sex significantly lower tested Treatment were assessed were measured were used [DOI] 10.1002/art.42035 PMC 바로가기 [Article Type] Article
Antibody response to the COVID-19 ChAdOx1nCov-19 and BNT162b vaccines after temporary suspension of DMARD therapy in immune-mediated inflammatory disease (RESCUE)면역매개염증질환(RESCUE)에서 DMARD 치료를 일시적으로 중단한 후 COVID-19 ChAdOx1nCov-19 및 BNT162b 백신에 대한 항체 반응Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: RMD Open [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] Adult patients Antibody Response Antibody responses antirheumatic agents AstraZeneca AZ vaccine baseline biologic BNT162b Control control group control groups controls COVID-19 csDMARD dose Final first and second dose first dose first vaccination group groups IgG Immune-mediated immunogenicity inflammatory disease Messenger RNA multicentre not significantly different Patient Pfizer Protein randomised randomised controlled trial registration number response S1/S2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV2 second dose second vaccination Seroconversion seroconversion rate seroconversion rates significantly lower the antibody response the mean therapy titre titres U/mL vaccination Vaccine were measured [DOI] 10.1136/rmdopen-2022-002301 PMC 바로가기 [Article Type] Randomized Controlled Trial
Genomic, immunological, and clinical analysis of COVID-19 vaccine breakthrough infections in Beijing, China중국 베이징에서 코로나19 백신 돌발 감염의 게놈, 면역학 및 임상 분석Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Asymptomatic asymptomatic and mild cases Beijing both groups Breakthrough infection breakthrough infections CD4 Chain Reaction Characteristics China circulating clinical analysis Clinical outcome coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 vaccine COVID-19 vaccines database Delta delta variant Delta variants Efficacy elevated evaluate genomic IgG titer IgG titers immunological immunological characterization in both groups Infection lymphocyte median time Mild mild case mild cases no significant difference pandemic Patient patients polymerase chain polymerase chain reaction Quantitative SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus severe disease significantly significantly increased significantly lower T lymphocyte two groups two patients Vaccine vaccine breakthrough infections variant variants viral shedding whole genome whole-genomic analysis. [DOI] 10.1002/jmv.27636 PMC 바로가기 [Article Type] Article
Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia입원한 COVID-19 환자와 정상 인지, 경도 인지 장애 또는 알츠하이머 치매가 있는 비 COVID-19 환자의 혈청 신경퇴행성 바이오마커 비교Article Published on 2022-05-012022-09-11 Journal: Alzheimer's & dementia : the journal of the Alzhei [Category] MERS, 바이오마커, [키워드] Acidic Alzheimer's disease amyloid beta Biomarker Biomarkers Cognitive impairment Complication Control correlated COVID COVID patient Covid patients COVID-19 COVID-19 patient Dementia died discharge home discharged home disease elevated Encephalopathy GFAp Glial fibrillary acidic protein hospitalized COVID-19 patient hospitalized COVID-19 patients In-hospital In-hospital death light chain marker Mild Mortality neurodegeneration neurodegenerative neurofilament light chain Neurological complications outcome Patient phosphorylated Protein SARS-CoV-2 serum severity significantly significantly lower subject survival tau. UCHL1 [DOI] 10.1002/alz.12556 PMC 바로가기 [Article Type] Article
Reduced humoral response 3 months following BNT162b2 vaccination in SARS-CoV-2 uninfected residents of long-term care facilities장기 요양 시설의 SARS-CoV-2 감염되지 않은 거주자에서 BNT162b2 예방 접종 후 체액 반응 감소 3개월Article Published on 2022-05-012022-09-11 Journal: Age and Ageing [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adults antibody BNT162b2 BNT162b2 vaccine booster dose Care COVID-19 Cross-reactive immune responses delta variant Delta variants diminished effective elicit humoral humoral immune response humoral immune responses Humoral response humoral responses IgA antibodies IgA antibody IgG IgM immune immune responses Immunity individuals less Long-term care long-term care facilities mRNA neutralisation neutralisation activity nursing homes Older Older adults older people plasma Plasma levels PROTECT pseudovirus neutralisation assay reduced required SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2-specific IgG severe COVID-19 significantly higher significantly lower specific IgG antibodies uninfected vaccination Vaccine vaccine response variants virus vulnerable population was used were measured [DOI] 10.1093/ageing/afac101 PMC 바로가기 [Article Type] Article
Humoral immune response following prime and boost BNT162b2 vaccination in people living with HIV on antiretroviral therapy항레트로바이러스 요법을 받고 있는 HIV 감염자의 프라임 및 부스트 BNT162b2 백신 접종 후 체액성 면역 반응Article Published on 2022-05-012022-09-12 Journal: HIV medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-S IgG antibody Antiretroviral therapy ART BNT162b2 boost CD4 CD4 count CD4 T-cell cellular circulating Clinical efficacy Cohort Complete Concentration Control controls coronavirus coronavirus disease coronavirus disease 2019 (COVID-19) vaccination correlated COVID-19 COVID-19 vaccination domain examined Health care worker higher risk HIV HIV-1 HIV-negative humoral immune response Humoral immunity IgG immune response Immune status Immunoglobulin less majority Messenger RNA mounted mRNA mRNA vaccination neutralizing antibody Neutralizing antibody response outcome plasma PLHIV PLWH prime and boost priming produced receiving response RNA robust SARS-CoV-2 severe coronavirus disease significantly higher significantly lower T-cell the SARS-CoV-2 vaccination Variability Viral load WHO with HIV World Health Organization [DOI] 10.1111/hiv.13202 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the Pfizer/BioNTech SARS-CoV-2 mRNA third booster vaccine dose against the BA.1 and BA.2 Omicron variantsBA.1 및 BA.2 Omicron 변이체에 대한 Pfizer/BioNTech SARS-CoV-2 mRNA 3차 부스터 백신 용량의 안전성 및 면역원성Clinical and Translational Article Published on 2022-04-262022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Abstract adverse event AMED anti-spike antibody BA.1 BA.1.1 BA.2 BNT162b2 mRNA vaccine booster booster vaccination Booster vaccine breadth changes in Context cross-reactivity cytokine cytokine signature Delta dose evaluate evaluated finding funding groups healthcare worker Humoral immunity immunogenicity increase increase in individual Japan Live virus microneutralization mRNA mRNA vaccination Mutation neutralization neutralization ability Neutralization antibody neutralization titer Neutralizing Neutralizing antibodies neutralizing antibody no significant difference omicron Pfizer/BioNTech robust Safe Safety SARS-CoV-2 SARS-CoV-2 variants second vaccination sera significantly lower Spike protein subvariant supported the spike protein vaccination Vaccine vaccine dose Vaccine-induced immunity vaccinee variant variant of concern variants variants of concern VoC VOCs [DOI] 10.1016/j.medj.2022.04.013 PMC 바로가기 [Article Type] Clinical and Translational Article
Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series류마티스 관절염 환자에서 비활성화된 SARS-CoV-2 백신의 면역원성: 사례 시리즈Article Published on 2022-04-252022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] (C-reactive protein age analyzed antibody Antibody Response Antibody responses Arthritis Autoimmune disease C-reactive protein C-RP calculated CCP chemiluminescence Chinese Community COVID-19 disease dose ELISA ELISA kit erythrocyte sedimentation erythrocyte sedimentation rate ESR FIVE healthy control healthy subjects humoral IgG immune response immune responses immunofluorescence immunogenicity immunoturbidimetry in some inactivated inactivated SARS-CoV-2 vaccines Inactivated vaccine indirect immunofluorescence lowest lymph Medicine mRNA Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils no correlation not differ Patient patients peptide Protein receiving recruited reported Rheumatoid rheumatoid arthritis rheumatoid factor SARS-CoV-2 SARS-CoV-2 vaccine sedimentation rate Sery significantly lower Spearman correlation analysis Test Traditional Traditional Chinese medicine vaccination Vaccines was used were measured [DOI] 10.3389/fpubh.2022.875558 PMC 바로가기 [Article Type] Article
Brief Research Report: Virus-Specific Humoral Immunity at Admission Predicts the Development of Respiratory Failure in Unvaccinated SARS-CoV-2 Patients간략한 연구 보고서: 입원 시 바이러스 특이적 체액 면역은 예방 접종을 받지 않은 SARS-CoV-2 환자의 호흡 부전 발병을 예측합니다Article Published on 2022-04-252022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] Admission adult COVID-19 patient analyzed Antibody titer association carried Characteristics Clinical management Cohort COVID COVID disease severity COVID-19 cross-sectional development disease disease severity ELISA Evidence failure group hospital Hospital admission humoral humoral immune response Humoral response IgG IgG1 IgG3 IgM IgM 2 Infection lowest Neutralization assay Neutralizing neutralizing antibody Neutralizing antibody titer Neutralizing titer non-survivor Oxygen therapy participant Patient patients positive correlation Prognostic marker receiving required respiratory Respiratory failure response variable robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients serum sample severe disease significantly higher significantly lower survived Survivors the patient variable [DOI] 10.3389/fimmu.2022.878812 PMC 바로가기 [Article Type] Article