An analytical model of population level chronic conditions and COVID-19 related hospitalization in the United StatesResearch Published on 2022-02-012022-10-28 Journal: BMC Public Health [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] Admission age aligned baseline black cardiovascular disease chronic condition chronic conditions COVID-19 COVID-19 patient cumulative CVD decrease diabete diabetes Evidence Factor health system higher risk Hospitalization hypertension ICU ICU admission ICU admission rate intensive care management outcome pandemic population level Prevalence Probability provide public health reduction Result retrospective System the United State World Health Organization [DOI] 10.1186/s12889-022-12531-3 PMC 바로가기 [Article Type] Research
Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discoverySARS-CoV 파파인 유사 프로테아제(PLpro) 억제제로서의 나프틸 유도체 및 COVID-19 약물 발견에 미치는 영향 탐색Article Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis applied approach biochemical broad spectrum caused connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 derivative Drug discovery dynamic Dynamic simulation Environmental safety enzyme event HCoV Health Health Organization help human coronavirus implication Infection inhibiting inhibitor inhibitors Interaction lifecycle molecular molecular docking multitude Naphthyl derivative novel novel corona virus Novel coronavirus novel coronavirus disease Papain Papain-like protease PLPro protease Proteases provided public health Research robust SARS-CoV SARS-CoV PLpro SARS-CoV-2 Severe acute respiratory syndrome starting point target viral replication World Health Organization [DOI] 10.1007/s11030-021-10198-3 PMC 바로가기 [Article Type] Article
True or false: what are the factors that influence COVID-19 diagnosis by RT-qPCR?참 또는 거짓: RT-qPCR에 의한 COVID-19 진단에 영향을 미치는 요인은 무엇입니까?Review Published on 2022-02-012022-09-11 Journal: Expert review of molecular diagnostics [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Area catastrophic Chain Reaction coronavirus COVID-19 COVID-19 diagnosis deaths Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostic procedure diagnostic procedures disease evaluate expert Factor Health Organization help interfere Interpretation methodology molecular pandemic status patients polymerase chain polymerase chain reaction primer probe quantitative polymerase chain reaction resulting reverse transcriptase RT-PCR RT-PCR analysis RT-qPCR SARS-CoV-2 SARS-CoV-2 detection sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread the disease Transport Viral detection Viral load virus World Health Organization [DOI] 10.1080/14737159.2022.2037425 PMC 바로가기 [Article Type] Review
Utility of a commercial RT-qPCR assay to detect SARS-CoV-2 gene variations as an indicator of lineages혈통의 지표로서 SARS-CoV-2 유전자 변이를 검출하기 위한 상용 RT-qPCR 분석의 유용성Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] affected B.1.1.7 B.1.177 changes in circulating variant circulating variants community transmission concerning cycle threshold described detect Diagnosis evaluated Health Organization Infection Lineage lineages molecular Mutation N gene PCR RdRP RdRp gene reduce RT-qPCR RT-qPCR test S gene SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spread Surveillance target region the SARS-CoV-2 the SARS-CoV-2 virus variants Variation variations was performed WHO World Health Organization [DOI] 10.1016/j.jviromet.2021.114428 PMC 바로가기 [Article Type] Article
Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database세계보건기구(WHO) 국제 약물감시 데이터베이스를 사용한 렘데시비르와 관련된 심혈관 사건 및 안전성 결과Article Published on 2022-02-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI 95% confidence interval adjusted odds ratio ADRS Adverse drug reaction Adverse drug reactions Analysis approved bradycardia Cardiac arrest Cardiotoxicity cardiovascular Cell cell viability components conducted confounders consequence coronavirus disease Coronavirus disease 2019 COVID-19 database demonstrated dose-dependent drug Effects event FDA food Health Organization Hypotension in vitro experiment information International maintain Odds ratio outcome patients with COVID-19 performed physician reduced Remdesivir reported safety margin stem cell tolerable toxicities Toxicity Treatment US Food and Drug Administration viability WHO World Health Organization [DOI] 10.1111/cts.13168 PMC 바로가기 [Article Type] Article
Genomic Perspectives on the Emerging SARS-CoV-2 Omicron VariantArticle Published on 2022-02-012022-11-16 Journal: Genomics, Proteomics & Bioinformatics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] addition Affect alteration amino acid residue amino acid residues analyzed antigenicity B.1.1.529 circulating codon collected database detect Efficiency Genome genomic Genomics imperative IMPROVE Linkage disequilibrium Mutation nonsynonymous mutation occur omicron other variant Patient prevalent primer Protein Replication SARS-CoV-2 SARS-CoV-2 variants second sequence Surveillance the Spike variant variant of concern variants Viral genome sequencing viral nucleic acid was reduced World Health Organization [DOI] 10.1016/j.gpb.2022.01.001 PMC 바로가기
The Influence of Dissonance Induction and Assessment Reactivity in Improving Adherence to COVID-19 Precautionary Measures: A Cluster Randomised Controlled TrialRandomized Controlled Trial Published on 2022-02-012022-10-05 Journal: International dental journal [Category] COVID19(2023년), SARS, 임상, [키워드] adherence administration analysed analysis of variance asked assessment baseline Cluster Cognitive dissonance control group Controlled coronavirus coronavirus disease COVID-19 Dissonance Effectiveness Follow-up group groups Health behaviours. Improving induction influence Intervention knowledge Kruskal-Wallis magnitude measure Measures methodology pandemic participant proportion R 2 randomised controlled trial reactivity significantly significantly higher Spread study group suggested tested was measured were assessed WHO Wilcoxon signed-rank test World Health Organization [DOI] 10.1016/j.identj.2021.03.001 PMC 바로가기 [Article Type] Randomized Controlled Trial
An observational study for appraisal of clinical outcome and risk of mother-to-child SARS-CoV-2 transmission in neonates provided the benefits of mothers’ own milkObservational Study Published on 2022-02-012022-10-05 Journal: European journal of pediatrics [Category] COVID19(2023년), SARS, 임상, [키워드] Admission age approach Asymptomatic benefit Breastfeeding clinical Clinical outcome collected COVID-19 demonstrated discharged distress enrolled fetal Follow-up hospital incidence India Infant Infection intensive care majority morbidity Mortality mother Mother-to-child transmission Nasopharyngeal swab nasopharyngeal swab sample Neonatal Neonate Neonates outcome positive positive RT-PCR Precaution protocols provided recorded risk Rooming-in RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission STABLE suffered Support Swab symptomatic tested Transmission upper respiratory viral persistence virus transmission World Health Organization [DOI] 10.1007/s00431-021-04206-9 PMC 바로가기 [Article Type] Observational Study
Discovery and repurposing of artemisinin아르테미시닌의 발견과 용도 변경Review Published on 2022-02-012022-09-11 Journal: Frontiers of medicine [Category] Coronavirus, 신약개발, [키워드] Artemisinin Cancer China Chinese COVID-19 derivative Diseases drug Drug repurposing drug-resistant Health Organization healthcare help high potency implication Infectious disease Inflammation initial malaria paradigm shift parasite starting point TCM Toxicity Traditional Chinese medicine treat Treatment World Health Organization [DOI] 10.1007/s11684-021-0898-6 PMC 바로가기 [Article Type] Review
Strategies for COVID-19 vaccination under a shortage scenario: a geo-stochastic modelling approach부족 시나리오 하에서 Covid-19 백신 접종 전략 : 지리학 적 모델링 접근법Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 치료기술, [키워드] applied approach compartment country COVID-19 COVID-19 vaccination effective Epidemiology Evolution Health Organization Horizon Immunity immunization include infections Isolation Mobility open pandemic parameter positive reduce reduced repetition shown Spain Statistical physics, thermodynamics and nonlinear dynamics Strategy vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines virus Waves World Health Organization [DOI] 10.1038/s41598-022-05481-8 PMC 바로가기 [Article Type] Article