Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary FunctionSNP 및 SNP-by-Smoking 상호 작용의 게놈 전체 공동 메타 분석은 폐 기능에 대한 새로운 유전자좌를 식별합니다Research Article Published on 2012-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis applied association Author Autoimmune cigarette smoking compared complex conducted demonstrated differential expression DNER DQB1 Effect Effects European evaluated Evidence evidence of expiratory expressed FEV forced expiratory volume forced vital capacity found function Gene gene region Genetic genetic loci genetic risk factor Genome-wide association studies Genome-wide association study highlight HLA region HLA-DQA2 HLA-DQB1 Human airway epithelium human lung tissue identify implicated Interaction involved joint KCNJ2 loci lung Lung disease measure Meta-analysis meta-analysis model novel nucleotide Phenotypes polymorphism progression pulmonary Pulmonary function Region regions related shown single nucleotide Single nucleotide polymorphism smoker Smokers smoking SNP SNPs SOX9 study participant trait utility vital capacity Volume [DOI] 10.1371/journal.pgen.1003098 PMC 바로가기 [Article Type] Research Article
Virulent Avian Infectious Bronchitis Virus, People’s Republic of ChinaResearch Published on 2012-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis Antigen avian infectious bronchitis virus caused characterized chickens China Clusters death detected disease exhibit exhibited found Genetic IBV induce Infected Infection Infectious Bronchitis Virus isolate kidney lesion lesions lung pathogenicity People’s Republic of China Phylogenetic analysis phylogenetically prevalent proportion renal respiratory symptoms reverse transcription PCR tissue tropism virulence virulent virus virus isolation viruses [DOI] 10.3201/eid1812.120552 PMC 바로가기 [Article Type] Research
Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret ModelResearch Article Published on 2012-09-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute infection against SARS-CoV Antiviral antiviral therapeutics approach Coronaviral CoV develop expression ferret ferrets functional gene expression signature help highly pathogenic identify IFN response immune immune protection immune response Immunity immunized Immunopathogenesis inactivated Infected Infection infections Innate innate immune response inoculated IRG lung Lungs Model molecular Pathogenesis pathology prevalent protective immunity provide resource response SARS virus SARS-coronavirus SARS-CoV SARS-CoV infection SARS-like-CoV Vaccine vaccine candidate Vaccines virus [DOI] 10.1371/journal.pone.0045842 PMC 바로가기 [Article Type] Research Article
Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brainResearch Published on 2012-09-212022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] addition Adenovirus administration against SARS-CoV airway Antibody Response Antigen Brain CD8 comparable coronavirus effective examined IgA IgA antibody immune response Immunity immunization inactivated viruses indicate induce infect Infection intramuscular intranasal lung mice mucosa mucosal mucosal route Neutralizing olfactory protective immunity protein antigens recombinant recombinant adenovirus Result Safe SARS-CoV SARS-CoV spike protein serum Severe acute respiratory syndrome shown Spike protein Sublingual Sublingual administration T cell T cell response tissues vector virus Virus-like particle [DOI] 10.1186/1743-422X-9-215 PMC 바로가기 [Article Type] Research
Editorial: Macrophage heterogeneity and responses to influenza virus infectionArticle Published on 2012-07-012023-06-09 Journal: Journal of leukocyte biology [Category] 신종인플루엔자, [키워드] alveolar macrophage cytokine H5N1 lung monocyte Pathogenesis [DOI] 10.1189/jlb.0312130 PMC 바로가기
Primary Intravascular large B-cell lymphoma of lung: a report of one case and reviewCase Report Published on 2012-06-202023-08-30 Journal: Diagnostic Pathology [Category] E형 간염, [키워드] Clinicopathology Intravascular large B-cell lymphoma lung Primary [DOI] 10.1186/1746-1596-7-70 PMC 바로가기 [Article Type] Case Report
CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral InfectionResearch Article Published on 2012-05-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence Activation administration anti-viral response Author blocker Cancer CD200 clearance clinical trial Control dependent on determine determined different disease disease symptom ENhance Factor female female patient females Host humans Hypothesis IFN immune immune inhibitory immune response immune system immunological impair implication IMPROVE in vitro in vivo Infection influenza A virus Influenza virus inhibit inhibitory inhibitory signal lack Ligand lung MHV mice microbial infection mouse hepatitis neutrophil observé outcome overactive pathogen pathology pathway predict Prevent provided receptor receptors Release reported response Sex Sex difference Signaling supported suppresse therapeutic targeting therapeutic use threshold TLR7 Treatment Type I IFN type I interferon viral clearance viral infection virus virus infection [DOI] 10.1371/journal.ppat.1002710 PMC 바로가기 [Article Type] Research Article
Initial HRCT findings of novel influenza A (H1N1) infectionArticle Published on 2012-05-022023-06-09 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] H1N1 high‐resolution CT Influenza lung [DOI] 10.1111/j.1750-2659.2012.00368.x PMC 바로가기
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS VirusResearch Article Published on 2012-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome antibody C57BL/6 candidate vaccine caution challenge change changes in China component control group country dosage eosinophil evaluated exhibited ferret Histopathology Human hypersensitivity immunopathology inactivated indicated Infection infiltration Influenza initiated led to Live virus lung Lung disease mice NHP occurred Occurrence pathologic PBS pulmonary responses Result S protein SARS Coronavirus SARS-CoV SARS-CoV vaccine serum antibody Serum neutralizing antibody severe Significant reduction significantly spread to Th2-type the vaccine Vaccine Vaccine development virus VLP [DOI] 10.1371/journal.pone.0035421 PMC 바로가기 [Article Type] Research Article
Pathogenesis and Tissue Distribution of Avian Infectious Bronchitis Virus Isolate IRFIBV32 (793/B Serotype) in Experimentally Infected Broiler ChickensResearch Article Published on 2012-04-012022-10-29 Journal: The Scientific World Journal [Category] Coronavirus, [키워드] age Antibody titer Broiler bronchitis chicken Clinical sign collected control group demonstrated Depression detected digestive distribution exhibited experimental group indicated Infected Infectious Bronchitis Virus inoculated intranasally isolate kidney lung mild respiratory number of infected oviduct Randomly RNA serotype tissue Trachea two group various tissue viral disease Viral RNA virus virus detection was reduced [DOI] 10.1100/2012/402537 PMC 바로가기 [Article Type] Research Article