Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence주요 대립 유전자 참조 서열을 사용한 가족 4중주에서의 단계적 전체 게놈 유전적 위험Research Article Published on 2011-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele Analysis approach Author base pairs base pairs) Blood blood clot characterization coding compound heterozygosity contribute contributing to demonstrated develop disease disease risk disease-associated estimation facilitate family Gene genetic determinant genetic determinants genetic information genetic profile genetic risk genetic risk factor genetic risk factors Genetic variation Genome genomes Genotype Haplotype Human human leukocyte antigen identify Interpretation leukocyte loci lowest lung Major median medications methodology nuclear nuclear family occur pharmacological predisposition Pulmonary embolism quantification Quartet Recombination reference reference sequence risk Risk assessment risk for disease sequence Sequencing sequencing error sequencing errors therapy Thrombophilia variant whole-genome sequencing [DOI] 10.1371/journal.pgen.1002280 PMC 바로가기 [Article Type] Research Article
Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42Research Published on 2010-05-172022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Analysis Cell cellular processe complex confocal microscopy coronavirus Critical detected diploid ENhance fetal fibroblast found fusion protein GST host cell host cells host protein immunofluorescence Inflammatory responses interact Interaction involved knowledge lung molecular mechanism nucleocapsid protein pathogenicity pathway Result SARS-CoV severe Spread subunit the mean variety [DOI] 10.1186/1743-422X-7-99 PMC 바로가기 [Article Type] Research
Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of MiceArticle Published on 2010-04-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] acute respiratory distress syndrome ARDS Influenza lung Research viruses [DOI] 10.3201/eid1604.091061 PMC 바로가기
Innate Immune Response to H3N2 and H1N1 Influenza Virus Infection in a Human Lung Organ Culture ModelArticle Published on 2009-11-242023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] chemokine cytokine Influenza virus IP-10 lung MAPK MIP-1α [DOI] 10.1016/j.virol.2009.10.016 PMC 바로가기 [Article Type] Article
MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem CellsResearch Article Published on 2009-11-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus [DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory VirusesResearch Article Published on 2009-09-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus [DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivoResearch Published on 2009-08-242022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA [DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research
Immunohistochemistry for detection of avian infectious bronchitis virus strain M41 in the proventriculus and nervous system of experimentally infected chicken embryosResearch Published on 2009-02-052022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Affect age Allantoic fluid Antigen Brain bronchitis Cell chorioallantoic collected detected Diagnosis diagnostic different disease Embryo embryonic embryos fixed found gastrointestinal tract generate IBV IBV infection IHC immunohistochemistry induce Infected Infection Infectious Bronchitis Virus inoculated kidney kidneys liver lung M41 membrane MOST Myocardial nasal epithelium nervous system Neuron oviduct Pathogenesis PI Respiratory system Result sensitivity spleen strain Strains tissue tissue tropism vasculature virulence virus virus isolation [DOI] 10.1186/1743-422X-6-15 PMC 바로가기 [Article Type] Research