lung – Page 272 – Communicable Diseases Research

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

Research Article

Published on 2008-12-122022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study

Research Article

Published on 2008-02-292022-10-28
Journal: BMC Infectious Diseases [Category] Coronavirus,

Pathogenetic mechanisms of severe acute respiratory syndrome

Article

Published on 2007-09-072022-11-01
Journal: Virus research [Category] Coronavirus, MERS,

[키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while
[DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Research Article

Published on 2007-08-102022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication
[DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

Article

Published on 2007-04-232022-11-01
Journal: Virus research [Category] Coronavirus, MERS,

[키워드] addition airway airway epithelial cells airway epithelium Antisera apical surface Atypical Calu-3 Calu-3 cell Cell cells cellular Characteristics ciliated ciliated cell consequence coronavirus coronavirus pathogenesis Coronavirus replication Culture cultures detected develop did not reduce dry cough efficient enzyme Epidemics epithelial epithelial cell epithelial cell line Experimental result feature Fever fluorescent Frame GFP hACE2 HAE Human human airway epithelia human airway epithelial Human airway epithelium human lung human pathogen in vitro in vitro model in vivo Infection inoculated insertion late stage log Lower respiratory tract lung lung epithelial mechanism Morphological new strain onset of symptoms ORF Pathogenesis pathology physiological Pneumonia Post-infection primary cell progeny virion Protein provide reached receptor reduced replicate replicated Replication reported reservoir respiratory virus resulting SARS Coronavirus SARS-CoV SARS-CoV GFP SARS-CoV infection Support susceptible target tight junction Trachea Vero E6 viral infection viral replication viral titer virus wild type zoonotic
[DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Research Article

Published on 2006-12-262022-10-29
Journal: PLoS Medicine [Category] Coronavirus, Fulltext, 조류인플루엔자,

[키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic
[DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article

Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus

Research

Published on 2006-03-292022-10-28
Journal: Virology Journal [Category] Coronavirus,

Time Course and Cellular Localization of SARS-CoV Nucleoprotein and RNA in Lungs from Fatal Cases of SARS

Research Article

Published on 2006-02-032022-10-29
Journal: PLoS Medicine [Category] Coronavirus, MERS,

[키워드] 2003 acute respiratory syndrome alveolar alveolar epithelium antiviral therapy appear assay association Autopsy Canada case cellular China Clinical course clinical disease collected compared coronavirus detected died disease etiological Evidence finding Hong Kong humans illness onset immunohistochemistry In situ Infected involved knowledge less Localization lung lung tissue Lungs Macrophage macrophages monoclonal antibody nucleoprotein outbreak Pathogenesis Patient patients with SARS pneumocyte Pulmonary pathology Region Replication RNA SARS Coronavirus SARS-CoV Seven symptom onset target the disease time Toronto Treatment viral infection virus widespread
[DOI] 10.1371/journal.pmed.0030027 PMC 바로가기 [Article Type] Research Article

G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells

Short Report

Published on 2005-08-172022-10-28
Journal: Virology Journal [Category] Coronavirus,

Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS

Research

Published on 2005-05-112022-10-28
Journal: Respiratory Research [Category] Coronavirus,

[키워드] abnormality acute phase acute respiratory syndrome alveolar cell alveolar macrophage Alveolar macrophages BALF Bronchoalveolar lavage Bronchoalveolar lavage fluid CD4/CD8 CD8 cell count cells clearance compared Computed tomography controls coronavirus correlated Course cytokine Cytokines described desquamation detected determine dysregulation Factor Fever High-resolution High-resolution CT HRCT hyaline membrane formation IL-6 IL-8 independent infiltration Inflammatory investigated lung Lung inflammation MCP-1 Microscopy mononuclear cell non-randomized occur Particle Patient patients persistence persistent Plasma cytokine profiles RANTES Resolution Result Retrospective analysis SARS SARS patient significantly subpopulations T lymphocyte T-cell therapy TNF-α
[DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research