Asynchronous actions of immune responses in COVID-19 patientsResearch Highlight Published on 2020-12-042022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Adaptive immunity COVID-19 patient immune response Infection [DOI] 10.1038/s41392-020-00424-z PMC 바로가기 [Article Type] Research Highlight
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infectionSARS-CoV-2 감염 후 중화 항체 및 T 세포 반응의 내구성Article Published on 2020-12-012022-09-11 Journal: Frontiers of medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity anti-SARS-CoV-2 blood sample Blood samples caused CD4 CD8 Cell collected convalescent coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient Critical Diagnosis Efficacy ELISA examined IgG IgG antibodies IgG antibody IgGs Immunity Infection interferon investigated memory N-protein Neutralizing activity Neutralizing antibodies neutralizing antibody no difference offer pandemic positive Post-infection predominant Probability pseudovirus respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus specimen T-cell T-cell Response triggered vaccination Vaccine variant variant of SARS-CoV-2 variants of SARS-CoV-2 [DOI] 10.1007/s11684-020-0822-5 PMC 바로가기 [Article Type] Article
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2감기 코로나바이러스와 SARS-CoV-2에 대한 건강한 기증자 T 세포 반응Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] 229E acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Cell characterized circulating common cold common cold coronavirus common cold Coronaviruses coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture determine Donor donors ELISPOT ELISpot assay enzyme enzyme-linked immunospot exposure to had no HCoV HCoV-229E HCoV-NL63 HCoV-OC43 healthy donor Immunity immunology in vitro Infectious disease influence memory T memory T cell NL63 Novel coronavirus nucleocapsid protein Nucleocapsid proteins OC43 outcomes peptide peptide pool peptide pools peptides Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seronegative severe acute respiratory syndrome Coronavirus Spike protein Spike proteins suggested T cell T cell response T cell responses T cells the spike protein virus [DOI] 10.1172/JCI143120 PMC 바로가기 [Article Type] Clinical Trial
Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization회복기 혈장 항-SARS-CoV-2 스파이크 단백질 엑토도메인 및 수용체 결합 도메인 IgG는 바이러스 중화와 상관관계가 있습니다Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity anti-RBD anti-receptor-binding domain anti-SARS-CoV-2 Anti-spike Asymptomatic breath Cellular immune response convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 disease COVID-19 treatment Critical decrease detect disease severity domain donors Dyspnea ectodomain highlight Hospitalization identify IgG IgG titer IgG titers immune immunology in vitro In vitro assay individual Infectious disease information Molecular pathology neutralization Neutralizing antibodies pathology patients with COVID-19 plasma positive correlation Probability Protective respiratory SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus significantly Spike protein surrogate titers Treatment Virus neutralization [DOI] 10.1172/JCI141206 PMC 바로가기 [Article Type] Clinical Trial
Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19순환하는 IgM 기억 B 세포의 고갈은 COVID-19에서 불리한 결과를 예측합니다Article Published on 2020-11-302022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] 95% CI Adaptive immunity age analyses B-cell Cell circulating Comorbidities coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cumulative cumulative incidence rate Depletion died enrolled female females hospitalisation hypothesised IgM immune response immune responses Immunopathogenesis Impaired incidence rate increased mortality Infection infections Infectious diseases internal medicine Italy lymphocyte Lymphocyte count Lymphocytes memory B memory B cell memory B cells not correlated number of comorbidities Older age outcome Patient patients with COVID-19 Peripheral blood predict reduction Sex specimen spleen Trigger two COVID-19 patients were excluded [DOI] 10.1038/s41598-020-77945-8 PMC 바로가기 [Article Type] Article
Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing혈장 IG 단백질체학 및 단일 B 세포 IG 시퀀싱에 의해 정의된 항말라리아 항체 레퍼토리Article Published on 2020-11-192024-08-11 Journal: JCI Insight [Category] 말라리아, [키워드] Adaptive immunity immunology malaria Vaccines [DOI] 10.1172/jci.insight.143471 PMC 바로가기
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease SeverityArticle Published on 2020-11-122022-10-04 Journal: Cell [Category] Fulltext, SARS, 유전자 메커니즘, [키워드] acute COVID-19 adaptive Adaptive immune response Adaptive immunity aging antibody Antibody Response Arm Biomarker CD4 CD8 connection convalescent coronavirus COVID-19 COVID-19 disease severity CXCL10 disease disease severity Epitopes highlighting identify immune response Immunity individual IP-10 knowledge limit Limited Multiple Neutralizing antibodies Neutralizing antibody response outcomes Protective protective immunity response responses risk factor SARS-CoV-2 scarcity severe COVID-19 spike subjects T cells [DOI] 10.1016/j.cell.2020.09.038 PMC 바로가기 [Article Type] Article
Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease SeverityMedicine Published on 2020-11-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute infection acute respiratory syndrome adaptive Adaptive immunity antibody Antibody Response blood sample caused CD4 CD4 T cell Cohort collected combating coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-reactive death described detectable disease severity Dynamics group Hospitalization IgG IgM immune Immunity individuals mild illness moderate neutralization neutralizing antibody no significant difference parameter patients with moderate response responses robust SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific T cells severe disease severe respiratory disease symptom onset T cell response the patient the timing therapy Viral load viral loads virus [DOI] 10.3389/fmed.2020.592629 PMC 바로가기 [Article Type] Medicine
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domainClinical Trial Published on 2020-11-092023-06-15 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity COVID-19 immunoglobulins immunology Influenza [DOI] 10.1172/JCI142804 PMC 바로가기 [Article Type] Clinical Trial
Peripheral CD4 + T cell subsets and antibody response in COVID-19 convalescent individualsClinical Trial Published on 2020-11-032023-06-14 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity COVID-19 immunoglobulins immunology T cells [DOI] 10.1172/JCI141054 PMC 바로가기 [Article Type] Clinical Trial