Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients염증 마커 miR-146a의 감소된 혈청 수준은 COVID-19 환자에서 토실리주맙에 대한 임상적 무반응과 관련이 있습니다Clinical Trial Published on 2021-01-012022-09-11 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] accounted adverse outcome affected age anti-IL-6 receptor biologic Biomarker Clinical course clinical response clinical trial COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity current death Decreased develop Digital disease droplet enrolled examined Health Healthcare systems healthy control inflammaging interleukin-6 interstitial pneumonia intravenous intravenous infusion lowest marker microRNA MicroRNAs miR-126 miR-146 miR-146a-5p miR-21 molecular non-responders Patient PCR quantified regulate respond responders RT-PCR Serum level serum levels serum sample serum samples subjects syndrome TCZ Tocilizumab Treatment [DOI] 10.1016/j.mad.2020.111413 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency departmentClinical Trial Published on 2021-01-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 임상, [키워드] 95% CI Accuracy adverse outcome Algorithm Analysis Biomarker Biomarkers characteristic Clinical sign Concentration coronavirus disease COVID-19 Endothelial dysfunction evaluated expressed health systems hospital Hospitalized Host identify IL-6 immune activation immune activation. Inflammatory likelihood ratio myeloid cell Outpatient Oxygen requirement pandemic Patient patients with COVID-19 PCR-confirmed COVID-19 patient predicted Predictive presenting prognostic Prospective respiratory rate risk stratification sensitivity soluble Triggering Receptor [DOI] 10.1016/j.jaci.2020.10.001 PMC 바로가기 [Article Type] Clinical Trial
Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis렘데시비르: 잠재적인 게임 체인저인가 아니면 단지 신화인가? 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-01-012022-09-11 Journal: Life sciences [Category] SARS, 치료제, [키워드] 95% CI adverse effects adverse outcome ARDS clinical Clinical improvement clinical recovery Coronavirus-2 Course COVID COVID 19 COVID-19 COVID-19 outbreak discharge rate drug discontinuation Efficacy fixed heterogeneity mechanical ventilation Meta-analysis Mortality Placebo public health Quantitative analysis quantitative synthesis random effect model reduced Remdesivir searched severe adverse effect significantly higher Standard of care systematic review therapeutic efficacy was performed [DOI] 10.1016/j.lfs.2020.118663 PMC 바로가기 [Article Type] Meta-Analysis
Prognostic value of bedside lung ultrasound score in patients with COVID-19COVID-19 환자의 병상 폐 초음파 점수의 예후 가치Observational Study Published on 2020-12-222022-09-11 Journal: Critical Care [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI 95% confidence interval abnormality acute respiratory distress syndrome (ARDS) Admission adverse outcome adverse outcomes ARDS C-index C-reactive protein categorical variable changes in Clinical significance consecutive patient consolidation continuous variable coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Cox model creatine creatine kinase criterion D-dimer detect died evaluated Follow-up hazard ratio highest hypersensitive incidence information interquartile range Invasive mechanical ventilation involved lowest lung lung involvement Lung ultrasound LUS score lymphocyte median median time MONITOR Mortality Non-invasive outcome Patient patients with COVID-19 predict predicted Prognosis Prognostic value protocol Result risk stratification sensitivity specificity Survivors troponin I was performed with COVID-19 zone [DOI] 10.1186/s13054-020-03416-1 PMC 바로가기 [Article Type] Observational Study
Cardiovascular implications of COVID-19 versus influenza infection: a reviewReview Published on 2020-12-182022-10-28 Journal: BMC Medicine [Category] COVID-19, MERS, SARS, [키워드] adverse outcome approaches cardiovascular cardiovascular disease Care clinical feature clinically Co-infection Complication coronavirus disease Coverage COVID-19 COVID-19 patient COVID-19 vaccination Critical care CVD death decrease Deep venous thrombosis diagnosed Diseases effective effort Epidemics Fatality rate Frequency Health higher risk highlight Hospitalization hospitalizations illnesses implication Implications Influenza Intervention manifestation Mortality overlapping Pandemics Patient patients hospitalized potential risk proportion ranged risk Seasonal influenza significantly increased similarity transmission rate vaccination Vascular vascular thrombosis [DOI] 10.1186/s12916-020-01816-2 PMC 바로가기 [Article Type] Review
Coronavirus-induced coagulopathy during the course of disease질병 경과 중 코로나바이러스 유발 응고병증Research Article Published on 2020-12-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 바이오마커, 진단, [키워드] Activation Administered adult COVID-19 patient adverse outcome age alteration Analysis analyzed anticoagulation Antithrombotic argatroban change Coagulation Coagulopathy comparable coronavirus coronavirus disease Course COVID-19 COVID-19 patient COVID-19 patients D-dimer D-dimer level D-dimer levels D-dimers decrease diagnosed disease elevated event fibrinogen fibrinogen level heparin heparin-induced thrombocytopenia Hospitalized hypercoagulability ICU incidence increased risk intensive care intensive care unit treatment investigated Laboratory low-molecular-weight-heparin male marker mean value observation period outpatients Patient patients died patients treated peak levels Platelet count Prophylaxis proportion prothrombin Prothrombin time receiving required Result retrospective Sensitivity analyses sensitivity analysis significant decrease single-center subsequent Switzerland the disease thrombin thrombin time thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events Thromboembolism Treatment two patients unfractionated heparin university venous ward [DOI] 10.1371/journal.pone.0243409 PMC 바로가기 [Article Type] Research Article
Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patientsCOVID-19로 인해 입원한 환자의 사망 및 중증 질환의 유병률 및 예측인자: 77건의 연구 및 38,000명의 환자에 대한 포괄적인 체계적 검토 및 메타 분석Research Article Published on 2020-12-072022-08-13 Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, SARS, [키워드] 95% CI adjusted adverse outcome adverse outcomes analyzed association China Chronic kidney disease chronic liver disease CKD CLD Comorbidities confidence interval COPD COVID-19 COVID-19 patient death determine diabete diabetes died disease Disease progression Europe fatality Health health screening heart disease heterogeneity Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients hypertension Inclusion inclusion criteria individual Infection Kidney disease male males Meta-analysis morbidity morbidity and mortality objective observational studies observational study Patient patients hospitalized predictor Prevalence Public reduce Relative risk Result risk risk factor Risk factors searched severe disease smoking susceptibility susceptibility to infection systematic review Web of Science [DOI] 10.1371/journal.pone.0243191 PMC 바로가기 [Article Type] Research Article
Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19Article Published on 2020-12-072022-10-04 Journal: Scientific Reports [Category] MERS, 치료법, [키워드] 30-Day mortality 95% CI Admission adverse outcome affected age biochemical blood pressure calculator Characteristics clinical conducted develop development died Diseases external validation feature high mortality hospital hospitalised identification identify increased risk individuals Infectious diseases Intensive International Intervention medical intervention Mortality multivariable logistic regression observation Odds ratio Patient patients Platelet predict Predictive Prognosis respiratory rate retrospective cohort study risk scale sensitivity Sex specificity United Kingdom viral infection were used with COVID-19 [DOI] 10.1038/s41598-020-78505-w PMC 바로가기 [Article Type] Article
Clash of the pandemics – At least 150’000 adults in Switzerland suffer from obesity grades 2 or 3 and are thus at elevated risk for severe COVID-19Research Article Published on 2020-12-072022-10-31 Journal: F1000Research [Category] COVID-19, MERS, [키워드] 95% CI Adiposity adverse outcome affected arising BMI body mass index conducted coronavirus disease courses COVID-19 COVID-19 pandemic elevated GRADE group help include knowledge lack lockdown men and women National NCD obese obesity Pandemics PROTECT public health Result risk Risk factors risk groups SARS-CoV-2 severe COVID-19 suffered Support Switzerland younger people [DOI] 10.12688/f1000research.27819.1 PMC 바로가기 [Article Type] Research Article
A biomarker based severity progression indicator for COVID-19: the Kuwait prognosis indicator scoreCOVID-19에 대한 바이오마커 기반 중증도 진행 지표: 쿠웨이트 예후 지표 점수Article Published on 2020-12-012022-08-31 Journal: Biomarkers : biochemical indicators of exposure, r [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcome age albumin Biomarker calculated calculator calibration Clinical course collected consecutive patient Course COVID-19 COVID-19 disease criterion CRP dataset death defined demonstrated Diagnosis disease severity Final Health Health policy Hospital admission Inclusion independent predictor independent predictors Infection Kuwait logit lymphocyte Mild monocyte Mortality Most patients Patient PCR percentage Pneumonia predict primary endpoint procalcitonin Prognosis prognostic model progression recruited resources respiratory distress risk serum albumin severe COVID-19 severe COVID-19 disease severity syndrome the disease variable with COVID-19 worldwide pandemic Wuhan Wuhan, China [DOI] 10.1080/1354750X.2020.1841296 PMC 바로가기 [Article Type] Article