Antiviral agents – Page 28 – Communicable Diseases Research

Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity

COVID-19 및 자가면역에서의 인터페론 및 기타 사이토카인, 유전학 및 그 이상

Review

Published on 2021-04-012022-09-11
Journal: Cytokine & growth factor reviews [Category] 유전자 메커니즘,

Old drug, new Trick? The rationale for the treatment of COVID-19 with activated protein C

오래된 약, 새로운 트릭? 활성화된 단백질 C로 코로나19를 치료하는 근거

Article

Published on 2021-04-012022-09-11
Journal: Medical Hypotheses [Category] 치료법, 치료제,

[키워드] activated activated protein C adaptive Antiviral agents antiviral treatments apixaban approach Aspirin clinical trial Coagulation consequence convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 therapeutics COVID-19 therapeutics. current described dysregulated immune response evaluated followed by heparin heparins Hope Hypothesis identify immune immune response immunomodulator immunomodulators Infection Inflammatory mechanism monoclonal antibodies Protein protein C researcher steroid Steroids therapeutic interventions therapeutic target Therapies therapy treating COVID-19 patient Treatment
[DOI] 10.1016/j.mehy.2021.110537 PMC 바로가기 [Article Type] Article

Telemedicine Chronic Viral Hepatitis C Treatment during the Lockdown Period in Romania: A Pilot Study

루마니아의 폐쇄 기간 동안 원격진료 만성 바이러스성 C형 간염 치료: 파일럿 연구

Article

Published on 2021-04-012022-09-10
Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료제,

[키워드] Antiviral antiviral agent Antiviral agents approach benefit Characteristics chronic chronic disease Chronic diseases chronic hepatitis chronic hepatitis C COVID-19 COVID-19 outbreak COVID-19 pandemic diagnosed direct antiviral agents disease example HCV Hepatitis hepatitis C implementation less lockdown management medication multidisciplinary approach offer older patient older patients pandemic Patient patients treated Period pilot study Romania Satisfaction satisfaction questionnaire statistically significant difference suggested sustained Telemedicine the patient therapeutic therapy treated were assessed
[DOI] 10.3390/ijerph18073694 PMC 바로가기 [Article Type] Article

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids

Article

Published on 2021-03-312022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] activity Affect Air-liquid interface AMP AMPs antimicrobial antimicrobial peptide Antiviral antiviral activity Antiviral agents antiviral drug antiviral drugs antivirals appear approach Bioavailability candidate caused clinical development COVID-19 cryo-EM cytotoxicity effective epithelial cells examined Factors glycine Herpe host cell membranes HSV-1 in vitro incubated Infection infections LL-37 mechanism membrane disruption molecular feature oligomers peptides Peptoid peptoids potent primary culture Proteases Safe SARS-CoV-2 shown stability treat unique viral envelope viral particle virus viruses Visualization
[DOI] 10.3390/ph14040304 PMC 바로가기 [Article Type] Article

A Multifunctional Peptide From Bacillus Fermented Soybean for Effective Inhibition of SARS-CoV-2 S1 Receptor Binding Domain and Modulation of Toll Like Receptor 4: A Molecular Docking Study

Molecular Biosciences

Published on 2021-03-312022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] Bacillus spp. 6M0J Accessibility ACE2 Amino acid analyzed Antiviral antiviral activity Antiviral agents antiviral peptides Asian Bacillus Bacillus subtilis binding binding interaction cell receptor Combination complex Contact contributed coronavirus 2 country COVID-19 Critical Cytokine storm differentiation docked complex fermented soybean Generalized glycoprotein human Angiotensin-converting enzyme immunomodulation in silico India inhibition Interaction interactions investigated Like modulation molecular docking motif PDB peptide Prophylaxis Protein proteome RBD receptor residue respiratory SARS-CoV-2 SARS-CoV-2 S1 screened selected soybean spike strain the receptor-binding domain the S1 protein TLR4 TLR4/MD2 complex Viral diseases ZDOCK
[DOI] 10.3389/fmolb.2021.636647 PMC 바로가기 [Article Type] Molecular Biosciences

Amantadine Inhibits SARS-CoV-2 In Vitro

Amantadine은 시험관 내에서 SARS-CoV-2를 억제합니다

Brief Report

Published on 2021-03-242022-09-10
Journal: Viruses [Category] SARS, 치료제,

[키워드] administration airway epithelium amantadine analogy antiviral activity antiviral agent Antiviral agents antiviral drug antiviral drugs approved Concentration COVID-19 demonstrated drug treatment drug treatments Efficacy Evidence Face mask Face masks health emergency Hypothesis in vitro infected with SARS-CoV-2 Influenza influenza A inhalation inhibited intranasal intranasal instillation mandatory Measures pandemic protective vaccine protective vaccines SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication separate experiment severity social distancing tested the SARS-CoV-2 therapeutic Vaccine Vero E6 Vero E6 cell VERO E6 cells
[DOI] 10.3390/v13040539 PMC 바로가기 [Article Type] Brief Report

Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

Review

Published on 2021-03-222022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2

스파이크 단백질의 돌연변이와 ACE2의 대립유전자 변이는 SARS-CoV-2에 대한 표적 치료 전략에 영향을 미칩니다

Article

Published on 2021-03-182022-09-11
Journal: Zoological research [Category] SARS, 변종,

[키워드] ACE2 ACE2 expression ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele Amino acid analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antiviral agent Antiviral agents binding caused Chinese clinical Clinical data Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression docking domain drug drug therapy effective English enzyme enzyme-linked immunosorbent assays exhibited genetic data interact Mortality mutant Mutation pandemic Patient peptide Point mutation populations Protein Receptor binding Receptor-ligand docking Renin renin-angiotensin system Research SARS-CoV-2 SARS-CoV-2 pandemic Sequence analysis severe acute respiratory syndrome Coronavirus spike Spike protein Spread Symptom target targeted therapy targets the SARS-CoV-2 the spike protein Transmission treat Treatment treatment of COVID-19 Vaccine variant Variation
[DOI] 10.24272/j.issn.2095-8137.2020.301 PMC 바로가기 [Article Type] Article

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

항바이러스 약물 검사를 통해 DNA 손상 반응 억제제가 SARS-CoV-2 복제의 강력한 차단제임을 확인

Report

Published on 2021-03-182022-09-11
Journal: Cell Reports [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제,

[키워드] Abstract Anti-SARS-CoV-2 Activity antiviral activity Antiviral agents ATR ATR kinase berzosertib block blocked cell type cell types cellular cellular signaling pathway cellular signaling pathways clinical trials Compound compounds coronavirus Coronavirus replication CoV infection COVID-19 Critical Cytopathic effect DDR DNA-damage response pathway drug drug candidate effective epithelial cell epithelial cells exhibited Health Health crisis high-throughput screen highlight host-pathogen interactions human epithelial cells identify inhibited inhibiting inhibitor inhibitors involved Kinase inhibitor kinase inhibitors library MAPK mechanism MERS MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus modulate mTOR mTOR-PI3K-AKT pathway multiple coronaviruses nucleoside analogs Pathways PI3K precipitated Protein protein kinase protein kinase inhibitor protein kinase inhibitors provide Replication respiratory respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown signaling cascades signaling pathway signaling pathways Stage the SARS-CoV-2 therapeutic therapy Treatment treatment of COVID-19
[DOI] 10.1016/j.celrep.2021.108940 PMC 바로가기 [Article Type] Report

Evaluation of the Current Therapeutic Approaches for COVID-19: A Systematic Review and a Meta-analysis

Pharmacology

Published on 2021-03-152022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Antibiotics Antiviral Antiviral agents antivirals applied Arbidol clinical feature Clinical improvement Clinical treatment Combination Corticosteroid COVID-19 COVID-19 mortality COVID-19 patients COVID-19 severity COVID-19 therapeutics COVID-19 treatment current death Dexamethasone Disease progression effective Efficacy and safety higher risk Hospitalization Hydroxychloroquine incidence involved Limited management Meta-analysis Mortality not significant objective outcome performed prevalent raised reduce reduced reducing Remdesivir review ribavirin Safe severe adverse events significantly SMD standardized mean difference treating COVID-19 Treatment treatments of COVID-19 use of corticosteroid use of hydroxychloroquine
[DOI] 10.3389/fphar.2021.607408 PMC 바로가기 [Article Type] Pharmacology