Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunitySARS-CoV-2 변이 스파이크 에피토프의 인식에서 벗어나 T 세포 면역의 전반적인 보존Article Published on 2022-02-092022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Ability to protect Affect African Beta Beta variant CD4 CD4 T cells CD8 CD8 T cell CD8 T cell responses COVID-19 patient detectable dominant Efficacy epitope Epitopes escape explain First wave first-wave immune evasion Immunity immunogenic mounted mutated neutralization neutralizing antibody observation Patient patients peptide peptides preserved proportion PROTECT Recognition recognize Region regions Reinfection residue response retained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 severe disease South spike epitope spike epitopes spike mutation spike mutations T cell T cell response T cell responses T cells tested Vaccine vaccine efficacy variant wild-type Wuhan strain [DOI] 10.1126/scitranslmed.abj6824 PMC 바로가기 [Article Type] Article
A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle푸린을 표적으로 하는 실행 가능한 대안 전략은 SARS-CoV-2 감염 주기를 방해합니다Research Article Published on 2022-02-092022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Activation addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody Response applicability approach binding blockade Cell cellular entry chain cleavage competing coronavirus COVID-19 Critical cycle described disease pathology DNA domain effective Efficacy epitope flexible linker furin Health Hospitalization Host host cell host cells host protease human lung cell human lung cells IgG1 Immunological memory in viral independent Infection infection cycle infections interfere lung cells membrane fusion Mortality occur overcome peptide plug processing producing protease Proteases proteolytic activation Proteolytic processing public health threat remained remains uncertain residue RNA SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viral particles scenario secretory pathway solution spike glycoprotein Spike protein Strategy subsequent targeted therapy targeting the spike protein Transmission Vaccine Viral viral entry Viral transmission virus virus-producing cell virus-producing cells viruses [DOI] 10.1128/spectrum.02364-21 PMC 바로가기 [Article Type] Research Article
Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics developmentResearch article Published on 2022-02-092022-10-05 Journal: Current Research in Structural Biology [Category] 변종, [키워드] ACE-2 receptor amino acid residue amino acid residues amino acid substitution analysed assigned binding complex COVID-19 pandemic COVID-19 therapeutics develop disease Drug design sites epitope Epitope sites human SARS-CoV-2 Human SARS-CoV-2 mutations Interaction Invariant sites monoclonal antibodies mutated Mutation Mutation propensity occur outbreak PDB Protein Protein Data Bank protein sequence Receptor binding domain remained reported residue SARS-CoV-2 spike protein sequence Seven Spike protein Spike protein sequence Spike proteins target the SARS-CoV-2 the spike protein variant variants VoC Wuhan-Hu-1 [DOI] 10.1016/j.crstbi.2022.01.002 [Article Type] Research article
Identification of immunodominant epitopes on nucleocapsid and spike proteins of the SARS-CoV-2 in Iranian COVID-19 patients이란 COVID-19 환자에서 SARS-CoV-2의 뉴클레오캡시드 및 스파이크 단백질에 대한 면역우성 에피토프 식별Article Published on 2022-02-092022-09-11 Journal: Pathogens and disease [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Amino acid amino acids Analysis Antibody Response binding conformational COVID-19 COVID-19 infection COVID-19 patient determine Diagnosis diagnostic Disulfide domain dominant ELISA entire sequence enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes experiment healthy subject identification IgG response immunodominant epitope immunodominant epitopes immunogenic Immunotherapy information life-threatening linear epitopes moderate no significant difference no significant differences nucleocapsid overlapping pandemic Patient pepscan peptide peptide pools peptides Protein RBD RBD of SARS-CoV-2 reactivity Receptor binding domain Receptor-binding domain recombinant RBD protein reduced SARS-CoV-2 SARS-CoV-2 virus sera significant differences significantly lower Spike protein structural proteins target targets the RBD the SARS-CoV-2 Viral was performed western blotting [DOI] 10.1093/femspd/ftac001 PMC 바로가기 [Article Type] Article
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection인간 항체는 베타-코로나바이러스 스파이크 단백질의 보존된 부위를 드러내고 SARS-CoV-2 감염에 대한 보호를 제공합니다Research Article Published on 2022-02-082022-09-14 Journal: Science Translational Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] adopted animal models antibody beta-coronavirus conserved controls coronavirus coronavirus disease CoV COVID-19 COVID-19 infection CoVs cross-neutralizing described description Donor Efficacy epitope exhibit exhibited Fab facilitate helical structure in vivo less lung viral titer mAb molecular basis neutralizing antibody peptide Prophylactic Protective Protective antibody reactivity reagent reduced residue reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S2 Spike protein target therapeutic treat Vaccine design Vaccines weight loss β-CoV β-CoVs [DOI] 10.1126/scitranslmed.abi9215 PMC 바로가기 [Article Type] Research Article
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchySARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다Research Article Published on 2022-02-082022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while [DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article
Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosisReview Published on 2022-02-082022-10-29 Journal: Journal of Nanobiotechnology [Category] COVID-19, [키워드] antibodies antigenic approach Atherosclerosis atherosclerotic cardiovascular disease complex diseases creating current CVD death diffusion Disease progression drug epitope expressed gene delivery lesion limitation limitations Nanobiotechnology Nanoparticles overcome pathological mechanism Perspective pharmacological progression Recombinant protein Side effect target Targeted drug delivery therapy thrombosis unique [DOI] 10.1186/s12951-022-01279-y PMC 바로가기 [Article Type] Review
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article
Leishmaniac Quest for Developing a Novel Vaccine Platform. Is a Roadmap for Its Advances Provided by the Mad Dash to Produce Vaccines for COVID-19?Review Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate adjuvanticity advance antigen-presenting cell APC application approach Cancer vaccine Candidates cationic CD8+ T cells cell inactivation Complete COVID-19 cytosolic DASH Developing disciplinary Diseases effective effectively deliver Efficacy elicit elicited ENhance epitope etiological agent greater highlight Immunity in vitro inactivated inactivation Leishmania Leishmaniasis life-long immunity mechanism MHC molecule microbe Mouse models novel OVA ovalbumin pandemic Patient predicted previous study processed Produce PROTECT provide quest reactive resulting SARS-CoV-2 short-lived shown singlet oxygen spike protein-based vaccine Support suppress susceptible the disease the vaccine these cell Trigger urgency vaccination Vaccine Vaccines whole-cell vaccine platform [DOI] 10.3390/vaccines10020248 PMC 바로가기 [Article Type] Review
Escherichia coli recombinant expression of SARS-CoV-2 protein fragmentsResearch Published on 2022-02-052022-10-29 Journal: Microbial Cell Factories [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] affinity tag Amino acid antibody antigenic antigenic protein approach C-terminal Carbohydrate-binding module CBM9 conserved COVID-19 Degradation E. coli epitope Escherichia coli expressed expression expression of SARS-CoV-2 flexible fusion protein human convalescent sera linker N-terminal overlapping protease Proteases Protective Protein purified Receptor binding domain Recombinant spike protein regions SARS-CoV-2 SARS-CoV-2 protein shown Spike protein supplementary material tested the SARS-CoV-2 [DOI] 10.1186/s12934-022-01753-0 PMC 바로가기 [Article Type] Research