A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research StudyOriginal Paper Published on 2020-10-192022-10-29 Journal: Jmirx Med [Category] COVID-19, [키워드] 95% CI Accuracy age Algorithm association Asymptomatic asymptomatic patient AUROC build carrier Cell characteristic China Chinese Clinical data Comorbidities Comparative Contact COVID-19 COVID-19 immunity COVID-19 symptom diagnosed differentiator District Effectiveness excluded explanation extreme Factor female growth hospital identify immune immune factor immune factors Immunity immunological individual infect infected with COVID-19 Infectious disease M-CSF machine machine learning machine learning analysis Macrophage male mass vaccinations median age Model objective observation Outbreaks outcome Patient patients patients with COVID-19 point of care positive predict predicted primary care Primary outcome programming public health relationship Research Result RT-PCR SARS-CoV-2 SCGF-β selected Sex single-center statistical statistically significant stem-cell growth factor-beta Symptom symptomatic symptomatic case Testing Therapeutics therapy Treatment treatment for COVID-19 understanding Vaccine were measured were recorded with COVID-19 [DOI] 10.2196/23582 PMC 바로가기 [Article Type] Original Paper
Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case reportCase Report Published on 2020-10-162022-10-28 Journal: BMC Endocrine Disorders [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Admission approach average Bronchoalveolar lavage Care Case report caused chronic condition clinician complications of COVID-19 COVID-19 defined diabete diabetes Diabetic diabetic patient doses Dyspnea dysregulation elevated extreme Glucose help High-dose homeostasis hyperglycemia infected with SARS-CoV-2 Infection insulin insulin resistance intensive care intravenous intubation knowledge management mechanical ventilation support mechanism medical condition mortality rate Myocardial infarction pandemic Patient patient with COVID-19 patients hospitalized patients with COVID-19 patients with diabete plasma positive presenting reduced report reported RT-qPCR SARS-CoV-2 Sepsis severe hypoxemia Switzerland syndrome transfer Transient treated Treatment type 2 diabete type 2 diabetes was performed worsening [DOI] 10.1186/s12902-020-00632-2 PMC 바로가기 [Article Type] Case Report
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age childrenAnalysis Published on 2020-10-152022-10-29 Journal: Scientific Data [Category] Coronavirus, MERS, SARS, [키워드] Adults age Analysis assumed Bacterial Bacterial infection children Course COVID-19 pandemic dataset Diseases extreme groups Health immune function immune senescence implication Infection infections Infectious disease information lowest manifestation Older age outcome reached relative Resilience Risk factors severe disease severity Severity of disease systematic analysis Vaccine vaccine response viral infection [DOI] 10.1038/s41597-020-00668-y PMC 바로가기 [Article Type] Analysis
Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeuticsArticle Published on 2020-10-102022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 유전자 메커니즘, [키워드] activated acute respiratory syndrome Adaptive immune response adipose administration ancestor antiviral drug clinical manifestation compounds connection contributing to Coronavirus disease 2019 coronavirus disease-2019 correlated COVID-19 COVID-19 patients current Cytokine storm Defense distribution event Exhaustion extreme faster fatality favor form gut microbiota immune response immune system Immunopathogenesis Immunotherapeutics inefficient Inflammatory responses innate immune response Interaction knowledge lethal manifestation marker MERS Middle East modulate Mortality NK cell occur patients public health emergency recent recognize respiratory response responses responsible SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 severity of COVID-19 similarity T cell tested the disease Therapeutic approach tissue Transmission Treatment upregulated virus virus entry [DOI] 10.1016/j.intimp.2020.107082 PMC 바로가기 [Article Type] Article
Impact on Air Quality of the COVID-19 Lockdown in the Urban Area of Palermo (Italy)Article Published on 2020-10-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] activity affected Air quality Area average calculated changes in CO–NO2–O3–PM10 Concentration coronavirus disease country COVID-19 decrease evaluate extreme FIVE global pandemic Human human behavior Impact infected individual Italy lockdown National number of infected outbreak produced Quality recorded reductions in Region reported significantly urban Urban environment Wuhan, China [DOI] 10.3390/ijerph17207375 PMC 바로가기 [Article Type] Article
Non-communicable diseases and inequalities increase risk of death among COVID-19 patients in MexicoResearch Article Published on 2020-10-082022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Compound COVID-19 COVID-19 patient death diabetes disease effective extreme Hospitalization hypertension individuals intubation National Non-communicable disease obesity outcome pandemic risk of death SARS-CoV-2 SARS-CoV-2 pandemic synergistic tested [DOI] 10.1371/journal.pone.0240394 PMC 바로가기 [Article Type] Research Article
Effect of Triple Combination Therapy With Lopinavir-Ritonavir, Azithromycin, and Hydroxychloroquine on QT Interval and Arrhythmic Risk in Hospitalized COVID-19 PatientsPharmacology Published on 2020-10-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] analyzed arrhythmia Arrhythmias Azithromycin baseline cardiovascular comorbidities Characteristics clinical feature Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients diabete Effect electrocardiographic extreme greater Hydroxychloroquine identify incidence increase in interval Lopinavir/ritonavir material Patient pharmacological prevalent provided QT interval QTc QTc interval QTC prolongation Result risk SARS-CoV2 stroke therapy torsades des pointes treated Treatment triple combination triple combination therapy was obtained was recorded ΔQTc [DOI] 10.3389/fphar.2020.582348 PMC 바로가기 [Article Type] Pharmacology
Onset of Ketosis-Prone Diabetes in the Setting of COVID-19 InfectionEndocrinology/Diabetes/Metabolism Published on 2020-10-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute infection acute respiratory syndrome antibody association Blood Cell changes in condition coronavirus coronavirus disease COVID-19 COVID-19 infection cross-react Diabetes Mellitus diabetes type 2 diabetic ketoacidosis diabetic ketoacidosis (dka) elevated extreme Hemoglobin A1c hyperglycemia IgG Immunoglobulin induce Infection insulin insulin resistance interfere ketosis prone diabetes laboratory result male mechanism Onset pancreatic PCR peptide Pneumonia polymerase chain positive presenting SARS-CoV-2 setting Stress Trigger type I diabete type II diabete Urine [DOI] 10.7759/cureus.10779 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukastResearch article Published on 2020-10-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 신약개발, [키워드] absence accumulate addition adipocyte adipose allergic rhinitis Anti-viral Antigen association Asthma Bame binding affinity cause Cell clinical trials Combination complications COVID-19 cytokine cytokine release decrease demonstrated disease drug drugs early stage effective elevated enzyme eosinophilia expression extreme greater Human ICU admission IL-1β IL-5 IL5 IL6 IL8 immune response Immune-mediated in silico increased mortality indicate individual Infection inflammatory cells inflammatory disease Injury leukotriene receptor antagonist Local mechanism Montelukast Mortality Multiorgan obesity occurred outcome paracrine Patient patients poor prognosis Pragmatic Prevalence protease reduce Replication resulting risk risk factor Safe SARS-CoV-2 severe COVID-19 severity shown suppress syndrome systemic inflammation the SARS-CoV-2 virus therapeutic therapeutic potential time-consuming tissue tissue damage treat Trigger upper respiratory tract Vaccine virus RNA visceral [DOI] 10.1016/j.mehy.2020.109883 [Article Type] Research article
Lessons learned from early compassionate use of convalescent plasma on critically ill patients with Covid-19Covid-19에 걸린 중환자에게 회복기 혈장을 초기에 동정적으로 사용하여 얻은 교훈Article Published on 2020-10-012022-09-12 Journal: Transfusion [Category] Coronavirus, SARS, 진단, [키워드] acute respiratory syndrome addition caused Clinical course clinical feature compassionate use condition convalescent plasma coronavirus coronavirus disease COVID-19 Critical Critically ill patient Cytokine storm disease onset extracorporeal membrane oxygenation extreme functional IgG Immunoglobulin Laboratory laboratory result lesson management neutralizing antibody Neutralizing antibody titer Patient patients patients with COVID-19 plasma Pneumonia positive produced Radiographic receiving required SARS-CoV-2 standard care tested therapeutic effect transfused Treatment Trial virus was collected with COVID-19 [DOI] 10.1111/trf.15975 PMC 바로가기 [Article Type] Article