Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-upCOVID-19 생존자의 지속적인 정신병리 및 신경인지 장애: 3개월 추적 관찰 시 염증성 바이오마커의 영향Article Published on 2021-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] MERS, SARS, 바이오마커, [키워드] affected age Anxiety baseline change cognitive Cognitive impairment COVID-19 COVID-19 pneumonia Depression depressive discharge domain dysfunction Effect evaluated executive executive functions fluency Follow-up function functions hospital hospital discharge immune response impairment implication Inflammation Inflammatory biomarker information information processing Insomnia investigated linkage Longitudinal studies lymphocyte male memory mental health neurocognitive neutrophil outbreak Patient patients with COVID-19 performed peripheral lymphocyte persistent physical Platelet platelet counts Pneumonia predicted prospective cohort study Psychiatric psychiatric history psychiatry psychomotor PTSD reflect Self-report questionnaires severity SII survivor Survivors Symptom systemic immune-inflammation index systemic inflammation Treatment verbal Viral viral infection Working memory [DOI] 10.1016/j.bbi.2021.02.021 PMC 바로가기 [Article Type] Article
Expression profiles revealed potential kidney injury caused by SARS-CoV-2: a systematic analysis of ACE2 and clinical lessons learned from this discovery발현 프로필은 SARS-CoV-2로 인한 잠재적인 신장 손상을 나타냈습니다: ACE2의 체계적인 분석 및 이 발견에서 얻은 임상 교훈Research Paper Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 ACE2 distribution ACE2 expression ACE2-positive cell ACE2-positive cells acute renal failure Admission Adults Analysis analyzed assessment assessments Blood urea nitrogen cause caused Cell city Clinical findings collected Collecting duct Comorbidities conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 positive patient creatinine Data analysis dataset EGFR elevated epithelial cells estimated glomerular filtration rate Evidence female filtration rate functions glomerular glomerular filtration rate healthy individuals hospital induce Infection infection site kidney kidney damage Kidney function Kidney injury kidney tissue Laboratory laboratory findings males nitrogen novel Novel coronavirus novel coronavirus disease organ organs pathophysiology Patient patients Pneumonia positive cells profile renal failure renal function reported retrospective RNAseq RNAseq data SARS-CoV-2 scRNA-seq data selected sequencing data serum creatinine single-cell Single-cell RNA sequencing systematic analysis the patient the SARS-CoV-2 Transcriptome transcriptome analysis urea urea nitrogen viral loads Wuhan Wuhan, China [DOI] 10.18632/aging.202224 PMC 바로가기 [Article Type] Research Paper
LUX: Smart Mirror with Sentiment Analysis for Mental ComfortArticle Published on 2021-04-292022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, MERS, SARS, [키워드] affective computing Analysis CNN Comfort COVID-19 dataset deep learning emotional English functions implementation include Korean lack Mental mental health Mirror Neutral NLP provide Raspberry Pi resulting sentiment analysis significant difference SmaRT smart mirror [DOI] 10.3390/s21093092 PMC 바로가기 [Article Type] Article
The Unfolded Protein Response and Autophagy on the Crossroads of Coronaviruses Infections코로나바이러스 감염의 교차로에서 펼쳐진 단백질 반응과 자가포식Review Published on 2021-04-282022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] addition autophagy autophagy machinery balance calcium cell death cellular cellular components cellular response Chloroquine component components conserved coronavirus Coronavirus infection CoV debatable debate Degradation drug Each Efficacy Endoplasmic reticulum environmental condition environmental conditions eukaryotic cell eukaryotic cells function functions generate highlighting homeostasis host-pathogen interaction in some include increasingly Infection infections instance integrated stress response involved matter mechanism modulate molecular interaction molecular mechanism molecular mechanisms niclosamide outcome pathway Pathways Perturbation perturbations promote Protein redox status replicative respond response SARS-CoV-2 pandemic signaling pathway spermine Stress suggested Support survival therapeutic options Topic Transcription translation unfolded protein response UPR Vesicle Viral viral infections viral replication virus viruses [DOI] 10.3389/fcimb.2021.668034 PMC 바로가기 [Article Type] Review
Interferon lambda in inflammation and autoimmune rheumatic diseases Reviews Published on 2021-04-272022-10-05 Journal: Nature reviews. Rheumatology [Category] 치료제, [키워드] Adaptive immune response addition Antiviral antiviral cytokine Autoimmune Autoimmune diseases Autoimmunity blockade Blood complex contribute Critical danger signals described Effect epithelial Evidence functions IFNα and IFNβ IFNλ immune dysregulation Immunity Infection Inflammation Inflammatory inhibit interferon Laboratory parameters modulate Pathogenesis pathogenic review rheumatic disease Rheumatic diseases Systemic autoimmune diseases systemic lupus erythematosus tissue tissue damage treatment strategy type I interferon type III interferon viral replication [DOI] 10.1038/s41584-021-00606-1 [Article Type] Reviews
Maternal natural killer cells at the intersection between reproduction and mucosal immunityReview Article Published on 2021-04-262022-10-31 Journal: Mucosal Immunology [Category] COVID-19, MERS, [키워드] Cell Contact COVID-19 fetal fetoplacental functions growth help homeostatic Immune cell immune cells Immunity Infection Influenza Intersection Local Macrophage malaria Maternal maternal tissue microenvironment mucosal natural killer natural killer cell NK cell NK-cell pathogen Placenta Pregnancy respond response systemically toxoplasmosis uterine vasculature [DOI] 10.1038/s41385-020-00374-3 PMC 바로가기 [Article Type] Review Article
Texas Public Agencies’ Tweets and Public Engagement During the COVID-19 Pandemic: Natural Language Processing ApproachOriginal Paper Published on 2021-04-262022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, [키워드] absence agency belief benefit build Characteristics characterized communication Community conducted content analysis COVID-19 COVID-19 pandemic creating disease disseminate dissemination Engagement function functions Government Health Health Belief Model IMPROVE information language Linear regression Local media morbidity and mortality National natural natural language processing objective pandemic predict predicted preventative measure processing promote provide provided Public public engagement public health public health agencies Public Health Agency responsible Result Self-efficacy severity social media Strategy susceptibility Twitter [DOI] 10.2196/26720 PMC 바로가기 [Article Type] Original Paper
Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches기계 학습 접근 방식을 사용하여 COVID-19의 심각도와 그 전사 프로그램의 세포 궤적 조사Article Published on 2021-04-242022-09-10 Journal: Genes [Category] MERS, 유전자 메커니즘, [키워드] Algorithm applied BALF Bronchoalveolar lavage fluid cellular change Complement pathway COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity deep learning disease severity driver Drivers function functions GATA3 Gene Expression identify Infection machine learning machine learning algorithm Machine learning algorithms Macrophage macrophages marker mechanism MITF pathway Program RNA sequencing SARS-CoV-2 virus SARS-CoV-2 virus infection severity single cell RNA-seq single-cell Single-cell RNA sequencing T cells the disease the SARS-CoV-2 virus tissue Trajectories trajectory trajectory inference transcription factor transcription factors transcriptional transcriptomic virus infection [DOI] 10.3390/genes12050635 PMC 바로가기 [Article Type] Article
Impact of COVID-19 Testing Strategies and Lockdowns on Disease Management Across Europe, South America, and the United States: Analysis Using Skew-Normal DistributionsOriginal Paper Published on 2021-04-212022-10-29 Journal: Jmirx Med [Category] COVID-19, [키워드] adopted Analysis approach Brazil caused changed confirmed case confirmed cases country COVID-19 COVID-19 infection COVID-19 outbreak COVID-19 pandemic Data analysis death deaths demonstrated displaying early stage effective Effectiveness Europe European European country evaluate examined example explain Factor First wave Forecast functions Germany greater highest Impact Infectious disease initial intensive care Isolation Italy liberal Local lockdown measure Metrics modeling mortality rate objective outbreak pandemic parameter parameters Portugal positive predicted prediction Probability Result skew-normal distributions South America spread of COVID-19 Strategy Switzerland Symptoms Testing Testing strategy the United State The United States Transmission transmission rate United Kingdom Variation [DOI] 10.2196/21269 PMC 바로가기 [Article Type] Original Paper
Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma회복기 혈장 내 다작용성 SARS-CoV-2 항체 마커Research Article Published on 2021-04-202022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC addition analyzed antibody Antibody Response antibody-dependent cellular cytotoxicity Antiviral antiviral activity Antiviral effect Better binding blood donor Blood donors Cell Characteristics complement Complement activation contribute convalescent convalescent individual convalescent plasma convalescent plasma samples coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Diversity Donor Efficacy eligible evaluate evaluated exhibited expand Features fraction function functional functional antibody response functions high accuracy Humoral response humoral responses IgA IgG individuals Intervention Mutation neutralization neutralizing capacity offer phagocytosis plasma plasma sample plasma samples reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapy treatment for COVID-19 validation cohort variant Viral viral neutralization [DOI] 10.1128/mBio.00765-21 PMC 바로가기 [Article Type] Research Article