Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines
Research Article
[키워드] acute respiratory syndrome
analyzed
antigen-presenting cell
Author
Cell culture
Cell-mediated immunity
cellular
Cellular immune response
coding sequence
coronavirus
Coronavirus infection
coronavirus vaccine
Coronavirus vaccines
Coronaviruses
Culture
deleting
dendritic cell
disease
elicited
Factors
Gene Expression
genetics
Heterologous
homolog
homologous
IFN
immune responses
implication
in vitro
in vivo
interfere
long-lasting
low dose
macrophages
Major
MHV
mice
mouse hepatitis virus
murine model
mutant
mutant virus
non-structural protein
pathogenicity
plasmacytoid dendritic cells
prevention
Protective
protective immune response
Protein
provide
recombinant vaccine
reduced
replicate
Replication
replication-competent virus
restored
retained
SARS-coronavirus
sequence
Spread
T cell response
tissue
Type I IFN
type I interferon
vaccination
Vaccine
viral disease
viral pathogenicity
viral pathogens
virus
wild-type
[DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.0030109 PMC 바로가기 [Article Type] Research Article