homeostasis – Page 28 – Communicable Diseases Research

Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells

Research Article

Published on 2016-04-202022-10-28
Journal: PLoS ONE [Category] Coronavirus,

Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다

Research Article

Published on 2016-03-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence ACVRL1 analyzed animals Antigen autosomal dominant autosomal dominant disorder auxiliary Bacteria balance blood monocyte blood monocytes C57BL/6 cell line characterized conditions contribute deficiency described develop differentiation disorder dominant dysplasia Endoglin endotoxin ENG explain expressed expression foci function help hemorrhage hemorrhages Hereditary Hereditary hemorrhagic telangiectasia homeostasis human cell human macrophages immune immune response Impaired in vitro in vivo increased survival Infection infection rate Infectious disease Infectious diseases Inflammation internal organs knock-out Laboratory leukemic leukemic cell Lineage Macrophage macrophages malformation mice monocyte monocyte-macrophage Monocytes Mortality mouse macrophages multisystemic patients Peripheral blood peripheral blood monocytes peritoneal macrophage peritoneal macrophages peritonitis Phagocytic activity predisposition Prevalence rare disease receptor recruited Rendu-Osler-Weber syndrome response responsible show Signaling surface antigen syndrome target gene Target genes TGF-β TGF-β1 transmembrane protein triggered type I up-regulation Vascular vessel wall was reduced Weber syndrome wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

Article

Published on 2014-10-072022-11-01
Journal: Virus research [Category] Coronavirus,

[키워드] activated activating Activation anti-apoptotic Apoptosis Apoptotic cell death ATF6 autophagy cause Cell coronavirus Coronavirus infection coronavirus protein cross-talk Degradation disturbance Endoplasmic reticulum ER stress eukaryotic cells Evidence facilitate homeostasis induce infected cells innate immune response Innate immunity Interaction involved knowledge Modification modulate occur pathological conditions pathway Pathways physiological pro-apoptotic pro-inflammatory cytokines pro-inflammatory response Protein protein synthesis Regulation Replication shown signaling pathway signaling pathways transcriptional translation transmembrane unfolded protein response UPR
[DOI] 10.1016/j.virusres.2014.09.016 PMC 바로가기 [Article Type] Article

A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific Abortifacients

RNA-seq 분석을 통해 태생 곤충에서 식별된 매우 다양한 새로운 단백질 패밀리: 체체 파리 관련 낙태 환자의 잠재적 표적

Research Article

Published on 2014-04-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Abortifacient addition African Amino acid amino acid sequence Analysis approaches casein cattle causative agents characterization coding control mechanisms Critical Differential analysis enrichment Factor family fecundity female functional genes encoding Genome genomic homeostasis Human Identified identify indicate insect Interference knockdown lactating lactation lipid metabolism maintenance mammalian mechanism mechanisms metabolism mother s milk novel occur organized Potential progeny Protein protein level protein synthesis Proteins proteome provided reduce reduced reducing Region reproductive resource RNA-Seq RNA-seq data secretion sequence similarity Seven shown similarities sleeping sickness specificity suppression synthesis target to define transcript Transcriptome transcripts Transferrin tsetse tsetse flies tsetse fly unique variant Viviparous were expressed while
[DOI] 10.1371/journal.pgen.1003874 PMC 바로가기 [Article Type] Research Article

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

CNNM2 돌연변이는 저마그네슘혈증 환자의 뇌 발달 장애 및 발작을 유발합니다

Research Article

Published on 2014-04-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accompanied Affect Brain brain development brain malformation brain malformations cation channel cause caused Cell cellular clinical variability CNNM2 Combination cRNA cyclin M2 de novo de novo heterozygous missense mutations demonstrated development Diagnosis disease Effect embryonic explain expressing FIVE gene encoding Genetic genetic cause genetic component genetic disease genetic etiology genetic heterogeneity handling HEK293 cell HEK293 cells heterozygous homeostasis human disease hypomagnesemia identify Impaired IMPROVE in vitro activity increase inheritance injection intellectual disability isoform kidney knockdown loss-of-function Magnesium mammalian Mental mental disability mental retardation Missense mutation mutant mutated Mutation neurodevelopmental impairment neurodevelopmental impairments neurological Neurological diseases occur Pathomechanism Pathomechanisms Patient patients with moderate phenotype Phenotypes physiological Physiology Protein reduced Regulation renal rescued Seizure Seizures shown the disease therapeutic drug Treatment TRPM7 unique wild-type zebrafish
[DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article

Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa

인간 아연 수송체 ZIP4(SLC39A4)의 극단적인 인구 차이는 사하라 사막 이남의 아프리카에서 양성 선택으로 설명됩니다

Research Article

Published on 2014-02-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence accompanied acrodermatitis acrodermatitis enteropathica African allele allele frequencies allele frequency Amino acid Author biological function Cell characterized classical computer simulations Concentration deficiency derived allele difference different directional disease phenotype disease risk DNA Evidence explained expression extreme finding fixation found functional Genetic Health HeLa cells homeostasis hotspot Human human population human populations implication intestinal investigated isoform leucine Local locus membrane Mutation natural selection Neanderthal Non-synonymous overexpression pathogen Pathogens polymorphism Population positive Positive selection Protein Recombination reduced reducing regulated Regulation Research Selection selective sweep significantly SLC39A4 sub-Saharan Africa surface protein Trace element transporter valine variant West Zinc zinc deficiency
[DOI] 10.1371/journal.pgen.1004128 PMC 바로가기 [Article Type] Research Article

Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?

Review

Published on 2012-05-152022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

[키워드] Activation adaptive Against antigenic arterivirus, porcine reproductive and respiratory syndrome virus CD25 CD28 CD4 CD8 Cell cells chronic inflammation Coronaviral coronavirus cytokine described develop disease Express expression form hallmark homeostasis host response IL-10 Immune homeostasis immune response immune tolerance induction Infection interleukin 2 lactate dehydrogenase lactate dehydrogenase-elevating virus maintain mean mouse hepatitis virus natural Other Pathogenesis PROTECT receptor Regulatory Regulatory T cell reproductive responsible subset syndrome T cell T cell subset T helper TGF-β the disease transcription factor Type viral persistence virus
[DOI] 10.3390/v4050833 PMC 바로가기 [Article Type] Review

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Research Article

Published on 2011-10-202022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced
[DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article

MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress

MK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다

Research Article

Published on 2011-08-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream
[DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article