innate immune response – Page 28 – Communicable Diseases Research

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

임상 관리 최적화를 위한 COVID-19 표현형의 인 실리코 역학

Biological Sciences

Published on 2021-01-192022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] 유전자 메커니즘,

A Review of Pathophysiology, Clinical Features, and Management Options of COVID-19 Associated Coagulopathy

Article

Published on 2021-01-142022-10-28
Journal: Shock (Augusta, Ga.) [Category] COVID-19, MERS, SARS,

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

COVID-19 및 Toll-Like Receptor 4(TLR4): SARS-CoV-2는 TLR4에 결합하고 활성화하여 ACE2 발현을 증가시켜 진입을 촉진하고 과염증을 유발할 수 있습니다

Review

Published on 2021-01-142022-09-10
Journal: Mediators of Inflammation [Category] 치료제,

[키워드] ACE2 activate Activation alveolar cell antagonist Antiviral appear ARDS bind binding cause causes causing Cell cell surface cells clinical trial contribute COVID-19 COVID-19 patients Cytokines decrease entry receptor Evidence expressed expression Facilitating heart failure hyperinflammation Immune cell immune cells include increase Infection Inflammation Injury innate immune innate immune response interferons lung Lungs Mortality multiorgan failure multiple-organ myocarditis PAMPs pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogenesis pathogenesis of SARS-CoV-2 pathophysiological Proinflammatory cytokine proinflammatory cytokines promise protein-protein interaction Pulmonary surfactants receptor recognize reported Respiratory failure SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike glycoprotein secrete Sepsis severe COVID-19 significantly spike glycoprotein Spike protein surface tension tension the cell the SARS-CoV-2 the spike protein the strongest therapeutic target TLR4 Treatment Trigger triggers type I interferon type I interferons Viral Viral protein Viral proteins
[DOI] 10.1155/2021/8874339 PMC 바로가기 [Article Type] Review

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

여러 세포 모델 및 임상 샘플에서 SARS-CoV-2에 대한 호스트 미토콘드리아 전사체 반응

Article

Published on 2021-01-082022-09-10
Journal: Scientific Reports [Category] 유전자 메커니즘,

Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections

Article

Published on 2021-01-072022-10-04
Journal: Cell Death & Disease [Category] 진단,

[키워드] Activation administration alleviate anti-inflammatory property biological processe Bronchoalveolar lavage fluid chemokine circulating co-culture co-cultured Concentration correlated counteract COVID-19 patients disease severity Effect Host implication in viral in vitro indicate Inflammation Inflammatory diseases Inflammatory response Influenza inhibiting innate immune response Interleukins lung Lung injury Lymphocytes Macrophage MAPK microenvironment mitigate neutrophil NF-κB signaling Pathways Pneumonia pro-inflammatory cytokine pulmonary inflammation reduced respiratory epithelial cell Respiratory tract diseases respiratory viral infection respiratory viral infections shown significantly Stat1 STAT3 therapeutic therapeutic target transcriptomic virus
[DOI] 10.1038/s41419-020-03283-2 PMC 바로가기 [Article Type] Article

Inactivation of Material from SARS-CoV-2-Infected Primary Airway Epithelial Cell Cultures

Letter

Published on 2021-01-072022-10-30
Journal: Methods and Protocols [Category] COVID-19,

[키워드] acute respiratory syndrome AEC airway airway epithelium BSL-3 BSL-3 laboratory CDC Cell Cell culture center conducted Control coronavirus COVID-19 Culture downstream Effectiveness epithelial epithelial cell evaluated experiment facilitate Factor fixation fixed formalin Guidance heat Heating immunohistochemistry inactivated inactivation Infection initial innate immune response Isolation Laboratory level 3 live SARS-CoV-2 material prevention primary human airway Protein protocol protocols RNA Safe SARS-CoV-2 SDS sodium supernatant tested transfer Treatment Triton X100 ultraviolet UV light Vero E6 Vero E6 cell viral entry virus
[DOI] 10.3390/mps4010007 PMC 바로가기 [Article Type] Letter

Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones

COVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬

Review

Published on 2021-01-012022-09-11
Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 Activation ADAM17 added angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral response Biological canonical cardiovascular disease caused contribute coronavirus COVID-19 COVID-19 pandemic Critical dependent on disease disease pathogenesis disease severity disintegrin epidemiological data exacerbate female females Gender genetics Health highlight increase in increasingly innate immune response innate immune system involved leads Loss male mechanism membrane metalloproteinase Mortality outcomes Pathways plasma positive positive feedback potential mechanism potential mechanisms protective mechanism proteolytic cleavage RAS receptor Renin renin-angiotensin system SARS epidemic SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection severe disease Sex sex differences sex hormone Sex hormones susceptibility the SARS-CoV-2 Viral viral entry worsened
[DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19

SARS-CoV-2는 인간의 장에서 SARS-CoV보다 더 강력한 선천 면역 반응을 유도하고 덜 효율적으로 복제합니다.

Article

Published on 2021-01-012022-09-11
Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 치료기술,

[키워드] Activation alternative route chemokines clinical observation clinical observations coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines dissemination Ex vivo gastrointestinal tract Gene Expression Gut Hong Kong Human human liver immune activation immunohistochemistry indicated infect infected with SARS-CoV-2 Infection Infectious virus Innate innate immune response interferon interferons intestinal epithelium intestinal tissue intestinal tissues intestine kidney tissues less manifestation Particles Patient patients plaque assays pro-inflammatory cytokine pro-inflammatory cytokines processed qRT-PCR replicate replicated Replication replication kinetics reported respiratory response robust SARS-CoV SARS-CoV-2 suggested surgical surgical operation surgical removal tissue tissues type I type I and type III interferons type III Type III interferons virus
[DOI] 10.1016/j.jcmgh.2020.09.017 PMC 바로가기 [Article Type] Article

Spatial and temporal roles of SARS-CoV PL pro -A snapshot

SARS-CoV PL pro -A 스냅샷의 공간적 및 시간적 역할

Review

Published on 2021-01-012022-09-11
Journal: FASEB journal : official publication of the Federa [Category] 치료법,

[키워드] 3CL pro accessory protein accessory proteins Antiviral appear autocleavage C-terminus can not cleave cleaved CoV replication cysteine cysteine protease dilemma domain E3 ubiquitin ligase envelope Factor inhibit inhibitor innate immune response Interaction interferon interferon-stimulated gene ISG15 its target protein its target proteins IκBα membrane motif NF-κB nonstructural protein nsp1 Nsp3 Nsps Nucleocapsid proteins p53 Papain Papain-like protease PLPro polyprotein polyproteins pp1a pp1ab promote protease Protein provide RCHY1 released Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 infections stimulator STING TNF ubiquitin unique Viral Zinc
[DOI] 10.1096/fj.202002271 PMC 바로가기 [Article Type] Review

SARS-CoV-2 infection and the antiviral innate immune response

SARS-CoV-2 감염과 항바이러스 선천 면역 반응

Review

Published on 2020-12-302022-09-10
Journal: Journal of Molecular Cell Biology [Category] SARS, 치료제,

[키워드] Antiviral innate immune response SARS-COV-2 infection
[DOI] 10.1093/jmcb/mjaa071 PMC 바로가기 [Article Type] Review