Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responsesSARS-CoV-2 감염의 무증상 사례에 대한 혈청학적 조사는 약하고 감소하는 항체 반응을 보여줍니다Research Article Published on 2021-05-182022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] Analysis antibodies antibody Antibody Response antibody-secreting cell Asymptomatic Asymptomatic case asymptomatic infection asymptomatic subject asymptomatic subjects B-cell breadth carried cellular response conducted contributed courses COVID-19 COVID-19 outbreak cytokine response declined declining decrease disease effective Factor Frequency Humoral immunity IgM and IgG immune response Immunity lymphopenia natural infection Neutralizing antibodies performed population immunity proportion recovered patients Reinfection reveal SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection serological serology Serosurvey significantly lower suggested symptomatic patient Vaccine weak antibody response Wuhan [DOI] 10.1080/22221751.2021.1919032 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 in animals: potential for unknown reservoir hosts and public health implications동물의 SARS-CoV-2: 알려지지 않은 저수지 숙주의 가능성 및 공중 보건 영향Review Published on 2021-05-142022-09-10 Journal: The Veterinary Quarterly [Category] SARS, 변종, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus animal animals bats cats China Contact coronavirus COVID-19 cynomolgus macaques determine Evidence evidence of facilitated ferret ferrets globe hamster Host host range Human human-to-human transmission implication initial instances mammalian mink natural infection populations public health raccoon dogs reported reservoirs respiratory Result rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant severe acute respiratory syndrome coronavirus 2 susceptibility susceptible Transmission transmission of SARS-CoV-2 transmitted Viral white-tailed deer wild animal wildlife reservoir zoos [DOI] 10.1080/01652176.2021.1921311 PMC 바로가기 [Article Type] Review
Infection and Immune Memory: Variables in Robust Protection by Vaccines Against SARS-CoV-2감염 및 면역 기억: SARS-CoV-2에 대한 백신의 강력한 보호 변수Review Published on 2021-05-112022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute phase Against Alter approved Asymptomatic basophils CD4+ CD8+ cells contribute convalescent individual death disease dysregulated eosinophils epitope identify Immune cell immune memory immune protection immune response immune system immunogenic Immunological memory individual individuals Infection inherent initial knowledge long-lasting macrophages maintain memory mild symptoms Monocytes MOST natural infection neutralizing antibody Neutrophils NK cells pandemic pathogen Patient populations progenitor cells protection question raise recent finding reduce SARS-CoV-2 SARS-CoV-2 epitope SARS–CoV-2 severe disease severity Spike protein T cells T memory cell Th17 cell the disease trajectory Vaccine Vaccine design variable [DOI] 10.3389/fimmu.2021.660019 PMC 바로가기 [Article Type] Review
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamstersResearch Article Published on 2021-05-092022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Administered Body weight loss change composed COVID-19 effective Efficacy expected hamster histopathological Immunity immunodominant in vivo less linear linker-immunodominant site lung viral load natural infection Neutralizing antibody response pandemic Pneumonia PROTECT Protective SARS-CoV-2 severe COVID-19 significantly Spike protein subcutaneous injection tested the RBD the SARS-CoV-2 unlikely vaccination Vaccine vaccine candidate [DOI] 10.1080/22221751.2021.1921621 PMC 바로가기 [Article Type] Research Article
Host barriers to SARS-CoV-2 demonstrated by ferrets in a high-exposure domestic setting높은 노출 국내 환경에서 흰 족제비에 의해 입증 된 SARS-CoV-2에 대한 호스트 장벽423 Published on 2021-05-042022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Angiotensin-converting enzyme Antibody assays barrier circulating cleavage Contact coronavirus COVID-19 decrease demonstrated direct contact discrepancy Effect Efficiency environmental exposure Evidence evidence of experiment exposure to Factor ferret ferrets furin Genetic genetic factors genetics Host host adaptation hosts Human hypothese idea Infection Laboratory limit Mutation natural experiment natural infection no evidence of onward transmission positive predicted provide raising respiratory respiratory virus respiratory viruses risk S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 susceptibility SARS-CoV-2 transmission second sequence severe acute respiratory syndrome Coronavirus shown Significance spike Support Surface glycoprotein susceptible symptomatic symptomatic COVID-19 symptomatic disease These data Transmission Viral viral adaptation Virology virus viruses while [DOI] 10.1073/pnas.2025601118 PMC 바로가기 [Article Type] 423
Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workersSARS-CoV-2의 혈청학적 감시: 공중 보건 종사자 집단의 6개월 추세 및 항체 반응Article Published on 2021-05-012022-09-11 Journal: The Journal of Infection [Category] Fulltext, SARS, 진단, 치료기술, [키워드] Abbott antibody Antibody Response Antibody responses assays changed clinical Cohort Course credible interval Critical declined dependent on domain Effect England English Euroimmun FIVE healthcare worker healthy Immunity immunoassays individual Infection large cohort MOST natural infection nucleoprotein occurred positive positive individuals progression proportion Protein public health RBD recruited reduction in Region remained response Roche SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike Seroconversion seropositive Surveillance tested the epidemic threshold trend vaccination [DOI] 10.1016/j.jinf.2021.03.015 PMC 바로가기 [Article Type] Article
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort다민족 COVID-19 코호트에서 연령, 질병 심각도 및 인종이 체액 반응에 영향을 미침Article Published on 2021-04-282022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료법, [키워드] affected age Antibody titer Antibody titers breadth C-terminal Case-control Cohort cohorts Complete Control Coverage COVID-19 COVID-19 pandemic disease severity domain Efficacy epitope epitope coverage Ethnicity expected Factors Genetic gens globe humoral humoral immune response Humoral response immunoassay in some increasing age independent individual individuals influence intrinsically Localization magnitude Microarray Mild motifs natural infection nucleocapsid protein Older Patient Population Protein protein microarray provided quantitation Quantitative quantitative antibody binding Quantitative data regions reported response SARS-CoV-2 antibodies SARS-CoV-2 nucleocapsid protein SARS-CoV-2 viral Sensitivity and specificity Serological assay severe disease significant difference significant differences significant increase significantly significantly higher strength tested the microarray the viral nucleocapsid Vaccine vaccine efficacy Viral viral nucleocapsid protein [DOI] 10.3390/v13050786 PMC 바로가기 [Article Type] Article
Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera초기 유행성 혈청에 의한 우려의 SARS-CoV-2 변종에 대한 중화의 상관 관계Pathogenesis and Immunity Published on 2021-04-282022-09-10 Journal: Journal of Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies B.1.1.7 B.1.351 B.1.351 variant binding characterized clinical feature Cohort concern convalescent COVID-19 convalescent patient COVID-19 pandemic Critical cross-neutralization effective Evidence exacerbate homologous immune responses Immunity immunological Increasing Infection investigated mechanism Mutation N-terminal domain nAb response NAb responses NAb titers natural immunity natural infection neutralization Neutralizing antibodies neutralizing antibody NTD overcome pandemic primary mechanism promote RBD Receptor binding domain reduced reduction in response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly spike gene stimulated subjects susceptibility T cell T cell responses T cells These data Vaccine-induced immunity Vaccines variant variants Virological [DOI] 10.1128/JVI.00404-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacyResearch Paper Published on 2021-04-282022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] acute respiratory syndrome Antibody test appear Applying Biomathematics biostatistics Cohort complement conducted core coronavirus Corporation Critical diagnosed Efficacy elicit epidemiological Epidemiology Evidence finding Follow-up funding genetics Genome sequencing Genomics Immunity incidence incidence rate individual individuals Infection infections International investigated less median moderate MOST natural natural infection PCR positive PCR-positive Program PROTECT Public public health raising random Reinfection SARS-CoV-2 Seven specimen Swab through contact Viral genome sequencing were assessed [DOI] 10.1016/j.eclinm.2021.100861 PMC 바로가기 [Article Type] Research Paper
In vitro cell culture model of human nasal-associated lymphoid tissue (NALT) to evaluate the humoral immune response to SARS-CoV-2 spike proteinsOriginal Article Published on 2021-04-242022-10-28 Journal: Saudi Journal of Biological Sciences [Category] COVID-19, [키워드] absence anti-S IgG antibody concentration Antibody Response Antigen appear candidate vaccine Cell Cell culture cells Cellular immune response co-cultured complete medium concerning coronavirus disease COVID-19 Culture demonstrated effort ELISA enzyme-linked immunosorbent assay evaluate full-length S full-length S protein Germany health authorities humoral immune response IgA IgM in vitro induce intranasally Lymphoid tissue Mild mononuclear cell mucosal natural infection nucleocapsid pandemic pathogenicity Patient Protein Proteins Result RPMI S protein S1 and S2 S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Saudi Arabia scientist secreted separated serious complication severe disease Significant subunit the S protein the SARS-CoV-2 tonsil used to evaluate Vaccine viral antigens Viral protein viral spike virus was used [DOI] 10.1016/j.sjbs.2021.04.051 PMC 바로가기 [Article Type] Original Article