SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021—Implementation of Swiss-Wide Diagnostic Screening and Whole Genome SequencingArticle Published on 2021-03-252022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Amplicon sequencing analysed B.1.1.7 B.1.351 Brazil Community COVID-19 described diagnostic epidemiological event Genome implementation Lineage Molecular epidemiology multiple laboratories Mutation N501Y P.1 PCR Phylogenetic analysis positive protocol public health rapid increase recommendation reported researchers SARS-CoV-2 Screening Sequencing South Africa Spread subsequent Surveillance Switzerland the SARS-CoV-2 variant variants of concern VOCs WGS whole genome [DOI] 10.3390/microorganisms9040677 PMC 바로가기 [Article Type] Article
First Identified Cases of SARS-CoV-2 Variant P.1 in the United States — Minnesota, January 2021미국에서 SARS-CoV-2 변종 P.1의 첫 번째 확인 사례 — 미네소타, 2021년 1월Full Report Published on 2021-03-122022-09-10 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, [키워드] Identified P.1 SARS-CoV-2 the United State [DOI] 10.15585/mmwr.mm7010e1 PMC 바로가기 [Article Type] Full Report
Stay-At-Home Orders Are Associated With Emergence of Novel SARS-CoV-2 VariantsInternal Medicine Published on 2021-03-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome association Brazil collected coronavirus coronavirus disease correlated correlation COVID-19 database death decrease demographics determine E484K E484K mutation eight emergence Evidence explain genomic variant GISAID index individual initiative Isolation lack Lineage material Ministry of Health mutants mutations new SARS-CoV-2 novel P.1 pandemic pathogenic positive correlation Prevalence public health reductions in Region regions Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants significantly SII social distancing social isolation Spearman variant variants was measured was obtained while [DOI] 10.7759/cureus.13819 PMC 바로가기 [Article Type] Internal Medicine
Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications새로운 SARS-CoV-2 변이체 B.1.1.7, B.1.351 및 B.1.1.28.1의 구조 기능 분석: 임상, 진단, 치료 및 공중 보건에 미치는 영향Article Published on 2021-03-092022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, 치료법, [키워드] 501Y.V1 501Y.V2 accumulated acute respiratory syndrome Anti-viral antibodies Antibody binding antibody resistance B.1.1.28.1 B.1.1.7 B.1.351 binding Brazil candidate Candidates circulation Clade G clinical COVID-19 COVID-19 vaccines current D614G variant described diagnostic diagnostic sensitivity diagnostic test diagnostic tests Effect epitope followed by functional furin cleavage site higher affinity host receptor Host receptors host tropism Immune escape impacts implication lead lineages Missense modulation molecular molecular dynamics multiple mutation multiple mutations Mutation N501Y N501Y mutation New nucleocapsid ORF8 P.1 Post-vaccine predicted Proteins Public public health public health strategies regions Reinfection resource respiratory roll S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome South Africa Spike protein the S protein therapeutic United Kingdom vaccine delivery variant while [DOI] 10.3390/v13030439 PMC 바로가기 [Article Type] Article
The effect of spike mutations on SARS-CoV-2 neutralizationSARS-CoV-2 중화에 대한 스파이크 돌연변이의 영향Report Published on 2021-03-062022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Abstract active against acute respiratory syndrome acute respiratory syndrome coronavirus Alter Amino acid amino acid changes amino acid substitution amino acids antibodies antibody Antibody Response Antibody responses B.1.1.7 B.1.1.7 variant B.1.351 change changes in collected convalescent sera coronavirus Critical decrease Divergence effective Efficacy ENCODE evaluate highlight Immune escape individual Infection less lineages mild illness monoclonal antibody Multiple mutants mutated Mutation mutations neutralization Neutralizing antibodies neutralizing antibody new SARS-CoV-2 P.1 polyclonal antibodies polyclonal antibody potency produced Protective Protein pseudotype Pseudotyped virus Real-time monitoring recognizing reduced respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 pseudotyped virus SARS-CoV-2 spike SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera serology serum sample serum samples severe acute respiratory syndrome Coronavirus spike mutation Substitution Vaccine vaccine efficacy variant variant spike Variation Viral viral entry [DOI] 10.1016/j.celrep.2021.108890 PMC 바로가기 [Article Type] Report
Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoVSARS-CoV-2 및 SARS-CoV 모두에 대해 교차 중화 활성을 갖는 인간 단일클론 항체인 MW06의 특성화Article Published on 2021-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition ADE alignment angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibody antibody-based therapy Antibody-dependent enhancement antibody-dependent enhancement (ADE) assays authorization B.1.1.7 B.1.351 B.1.617.1 bind caused characterization clinical trial cocktail complex conserved coronavirus coronavirus strains COVID-19 cross-neutralization activity cross-reactive demonstrated disrupt Effect effective effective interventions Emergency use epitope global pandemic Human monoclonal antibody in vitro assays Interaction Intervention mAb mAbs monoclonal antibody mutations neutralization neutralization activity neutralization. neutralizing monoclonal antibodies P.1 Phase 2 Potential Prevent Prophylactic provide RBD receptors recognize respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-related coronavirus severe acute respiratory syndrome Coronavirus spike receptor-binding domain Strains therapeutic efficacy Treatment treatment of COVID-19 variant variants variants of concern widespread [DOI] 10.1080/19420862.2021.1953683 PMC 바로가기 [Article Type] Article