Nested pool testing strategy for the diagnosis of infectious diseases전염병 진단을위한 중첩 풀 테스트 전략Article Published on 2021-09-132022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] Assay systems best can be used Definition Diagnosis digital PCR Epidemiology gold gold standard Hierarchical High-throughput screening identify implementation infected individual infected individuals Infectious disease Mathematics and computing pandemic pooling Population screening proceed provide quantification raise RNA RT-qPCR SARS-CoV-2 pandemic shown solution tested the SARS-CoV-2 [DOI] 10.1038/s41598-021-97534-7 PMC 바로가기 [Article Type] Article
A Bioluminescent 3CL Pro Activity Assay to Monitor SARS-CoV-2 Replication and Identify InhibitorsArticle Published on 2021-09-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3CL activity Anti-SARS-CoV-2 Activity Antiviral BAY2402234 Cell cell line cellular chemical screening cleavage site Compound Consensus coronavirus Coronaviruses Critical develop DHODH effective expressing expression firefly luciferase functional highlight identify inactive inhibitor inhibitors of SARS-CoV-2 IPPA-17-A04 NADPH oxidase Nasal Epithelial cells pandemic Prevent Pro protease quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Setanaxib structures therapeutic Therapeutic strategies Vidofludimus viral replication virus was used [DOI] 10.3390/v13091814 PMC 바로가기 [Article Type] Article
The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva인간 혈장 및 타액에서 Molnupiravir 및 대사 산물 β-d-N4-hydroxycytidine의 동시 정량을 위한 새로운 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-09-102022-09-10 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, SARS, 비임상, 치료기술, [키워드] Accuracy Acetate acetonitrile Ammonium Ammonium acetate analyte antiviral therapy caused clinical column concentrations conducted coronavirus Coronaviruses COVID-19 COVID-19 infection EIDD-2801 followed by global pandemic highly pathogenic Human plasma Infection Influenza LC-MS/MS linear m/z metabolite molnupiravir MPV N4-hydroxycytidine NHC Patient patients with COVID-19 pharmacokinetic plasma polar Precision protein precipitation quantification Saliva SRM Treatment validation was performed water [DOI] 10.1016/j.jpba.2021.114356 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 RNA in bivalve mollusks and marine sediments이매패류 연체동물 및 해양 퇴적물에서 SARS-CoV-2 RNA 검출Article Published on 2021-09-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료제, [키워드] addition Analysis analyzed Biomarker Bivalve mollusks capsids CLAM Contact contact with Contamination COVID-19 detection digestive genomic genus Gut information Marine environment Marine life non-infectious organism pandemic virus positive qPCR qPCR assay quantification quantified question ranged regions released RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sediment Sediments significantly higher statistical analysis target regions tissue viability Viral RNA virus wastewater [DOI] 10.1016/j.scitotenv.2021.147534 PMC 바로가기 [Article Type] Article
An integrated framework for building trustworthy data-driven epidemiological models: Application to the COVID-19 outbreak in New York CityResearch Article Published on 2021-09-082022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] acquisition addition adjusted Analysis application assumption available data calibrated COVID-19 COVID-19 outbreak data-driven deaths develop Effect epidemiological Evolution hospitalizations identify include Infection New York City pandemic Pandemics parameter parameters quantification SEIR sensitivity analysis Transmission dynamics Undetermined vaccination website [DOI] 10.1371/journal.pcbi.1009334 PMC 바로가기 [Article Type] Research Article
Integrated Microfluidic-Based Platforms for On-Site Detection and Quantification of Infectious Pathogens: Towards On-Site Medical Translation of SARS-CoV-2 Diagnostic PlatformsReview Published on 2021-09-072022-10-30 Journal: Micromachines [Category] COVID-19, [키워드] acute respiratory syndrome cause contagiousness coronavirus COVID-19 creating criteria current deaths detection diagnostic diagnostics effective Effectiveness eliminated Epidemics equipment evaluate example facilitate Health human population IMPROVE include increasingly infectious pathogens Laboratory limitation medical diagnosis MERS Microfluidics Middle East notable on-site outbreak pandemic Pandemics pathogen Pathogens platform quantification reported Research SARS-CoV-2 syndrome the WHO translate turnaround times [DOI] 10.3390/mi12091079 PMC 바로가기 [Article Type] Review
CT-Based Risk Stratification for Intensive Care Need and Survival in COVID-19 Patients—A Simple SolutionArticle Published on 2021-09-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Admission affected age approach AUC Computed tomography COVID-19 COVID-19 patient COVID-19 patients CT CT scan death developing countries diagnostic evaluated hazard ratio higher risk ICU ICU treatment increase in Infection instantaneous intensive care invasive ventilation lung Lung disease lung involvement Odds ratio pulmonary involvement quantification Resource allocation risk Risk assessment risk factor Risk factors SARS-CoV-2 semi-quantitative Sex significantly simple solution Support [DOI] 10.3390/diagnostics11091616 PMC 바로가기 [Article Type] Article
A Rapid, Isothermal, and Point-of-Care System for COVID-19 DiagnosticsCOVID-19 진단을 위한 신속하고 등온적인 현장 진료 시스템Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular techniques : JBT [Category] SARS, 치료기술, [키워드] applied Chain Reaction Combination Community Contact tracing COVID-19 COVID-19 pandemic Critical detrimental Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostic testing electrical evaluate example Human individual Infection infections Isolation isothermal isothermal amplification Laboratory lack LAMP Loop-mediated isothermal amplification measure mitigate nucleic acid pandemic pandemic progresse platform point-of-care polymerase chain polymerase chain reaction quantification Quantitative quantitative polymerase chain reaction Rapid reducing resource resources robust SARS-COV-2 infection SARS-CoV-2 virus Spread Surveillance System the SARS-CoV-2 virus Thermal energy wastewater [DOI] 10.7171/jbt.21-3203-019 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Wastewater Surveillance for Public Health Action공중 보건 활동을 위한 SARS-CoV-2 폐수 감시Online Report Published on 2021-09-012022-09-10 Journal: Emerging Infectious Diseases [Category] SARS, 치료기술, [키워드] Action acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed applicability Community complement Concentration coronavirus coronavirus disease COVID-19 Disease surveillance Infection knowledge over pandemic promise provided Public public health quantification reported researcher respiratory respiratory infections Responder SARS-CoV-2 SARS-CoV-2 viral RNA SARS-CoV-2 wastewater surveillance severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Surveillance translate Viral viruses wastewater zoonoses [DOI] 10.3201/eid2709.210753 PMC 바로가기 [Article Type] Online Report
Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 의한 기간 태반 감염에 대한 임상 및 시험관 내 증거Clinical Trial Published on 2021-09-012022-09-11 Journal: The American journal of pathology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell clinical consequence coronavirus coronavirus 2 coronavirus disease Defense demise during pregnancy enzyme expression fetus Host immunohistochemistry In situ hybridization Infection mechanism membrane mother Newborn not express Placenta Placental infection Placentas positive control Pregnancy Pregnancy confirmed protease Protein quantification question raise receptor Replication respiratory reverse transcriptase reverse transcriptase PCR SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virions Serine serine 2 severe acute respiratory syndrome Coronavirus supernatant syncytium term TMPRSS2 transmembrane transmembrane protease serine 2 Transmission undetectable Vero E6 vertical transmission virus [DOI] 10.1016/j.ajpath.2021.05.009 PMC 바로가기 [Article Type] Clinical Trial