Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ FailurePharmacology Published on 2020-11-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute lung injury acute respiratory distress adverse event AEs Affect Alpha Anti-inflammatory anti-inflammatory agents ARDS Cancer clinical Clinical course Clinical practice clinical study Compliance complications coronavirus disease COVID-19 COVID-19 patient Cytokine release syndrome dose-dependent dose-escalation double-blind evaluate examined exhibited failure GRADE growth factor healthy histopathological examination Human ICH include Inflammatory cytokine ingredient interleukin-6 intravenous Liver damage Model mortality rate mouse multi-organ dysfunction multi-organ failure Necrosis New niacinamide Patient patients phosphate placebo-controlled platform Pneumonia potent Preclinical Prevent profile Protective Pulmonary edema Randomized reduce respiratory response Riboflavin SAEs Safety safety profile Sepsis Serious Adverse Event Shock show Standard statistical analysis subject subjects survival syndrome Tolerability Treatment was performed [DOI] 10.3389/fphar.2020.594321 PMC 바로가기 [Article Type] Pharmacology
Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related ComplicationsConference abstract Published on 2020-11-042022-10-05 Journal: Blood [Category] 임상, [키워드] Activation Acute kidney injury acute lung injury acute respiratory distress AKI allergic ARDS Autoimmune capillary leak syndrome caused clinical clinical status clinical study CLR Complication complications COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm Diseases disorders double-blind download downstream Efficacy and safety Endothelial cell equity evaluate evaluated Fc receptor figure fostamatinib Hospitalized hospitalized COVID-19 patients Hyperactivation immune complex immune system immune systems Immune thrombocytopenia immunomodulatory effect implicated improvement incidence inhibitor involved kidney kinase LPS lung master regulator metabolite monocyte mouse model Nadeem neutrophil other treatment pathogen pathway Patient patients patients treated phase placebo-controlled plasma Platelets Prevent prevention Progress Protective Randomized receptor reduced reference Result rheumatoid arthritis risk safety profile Signal transduction Standard of care SYK syndrome target targeting the cytokine storm therapeutic strategy Thromboembolic event Thromboembolic events thrombosis tissue damage treated Treatment Van [DOI] 10.1182/blood-2020-141045 [Article Type] Conference abstract
Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution in COVID-19: Case SeriesOtolaryngology Published on 2020-11-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] approach being Clinical improvement Combination component coronavirus Course COVID-19 COVID-19 cases COVID-19 patients described early stage Efficacy entry of SARS-CoV-2 Extract Fork Grapefruit grapefruit seed extract GSE healthcare Inc. Infection initial intranasal medications nasal pathway PCR Potential profiles regulate Replication role safety profile SARS-CoV-2 SARS-CoV-2 virus seed Sery shown solution spray suggested supported Swab test symptomatic the disease Therapeutics Transmission treated Treatment USA viral pathogens virus while Xylitol [DOI] 10.7759/cureus.11315 PMC 바로가기 [Article Type] Otolaryngology
COVID-19 patients with psoriasis and psoriatic arthritis on biologic immunosuppressant therapy vs apremilast in North Spain북스페인에서 생물학적 면역억제제 대 아프레밀라스트에 대한 건선 및 건선성 관절염을 가진 COVID-19 환자Comparative Study Published on 2020-11-012022-09-12 Journal: Dermatologic therapy [Category] 진단, [키워드] acute respiratory distress acute respiratory syndrome anti-inflammatory cytokines apremilast autoimmune condition biologic clinical Clinical data clinically Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 patient Critical Cytokines Dermatology higher risk Hyperinflammatory illnesses immunomodulatory infected with COVID-19 Infection Inflammatory infliximab Lung injury management North outcome Patient patients psoriasis psoriatic arthritis rheumatology safety profile SARS-CoV-2 Seven severity shown Spain Symptoms the cytokine storm therapy Treatment [DOI] 10.1111/dth.13961 PMC 바로가기 [Article Type] Comparative Study
Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19COVID-19 치료에서 레닌-안지오텐신 시스템의 면역 조절제 및 조절제로서의 펜톡시필린의 재배치Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, [키워드] activate adenosine adenosine monophosphate alveolar epithelial cells angiotensin Anti-inflammatory approach AT1R balance cells circulation Concentration COVID-19 cyclic adenosine monophosphate Cytokines damage deleterious effect deleterious effects Endothelium epithelial cells Evidence expression helping highlight immune response immune system immunomodulator IMPROVE in vitro increase Inflammatory cytokine Inflammatory cytokines inhibiting inhibitor Microvascular thrombosis monophosphate mRNA offer patients with COVID-19 Pentoxifylline Prevent Proinflammatory cytokine proinflammatory cytokines Protein protein kinase RAS receptor reduce reduction in Renin renin-angiotensin system repositioning safety profile synthesis Therapeutic treatment thrombosis TNF-α Treatment treatment of COVID-19 turn ventilatory parameters Viral viral clearance [DOI] 10.1016/j.mehy.2020.109988 PMC 바로가기 [Article Type] Article
Comprehensive assessment of side effects in COVID-19 drug pipeline from a network perspectiveResearch article Published on 2020-11-012022-10-05 Journal: Food and chemical toxicology : an international jo [Category] SARS, 신약개발, 치료제, [키워드] adverse event Analysis antiviral therapeutics approach approaches association clinical evidence Clinical practice clinical trials CMap Comprehensive coronavirus disease Course COVID-19 COVID-19 drug drug drugs FDA food gene-set enrichment analysis global public health GSEA human tissue identify labeling lung Network proximity occurred OpenVigil patients with COVID-19 performed Perspective pharmacovigilance provide renal Safe safety profile SARS-CoV-2 Side effect therapeutic agent tissues Toxicity Treatment [DOI] 10.1016/j.fct.2020.111767 [Article Type] Research article
Hepatic Disorders With the Use of Remdesivir for Coronavirus 2019코로나바이러스 2019에 렘데시비르를 사용한 간 장애Multicenter Study Published on 2020-11-012022-09-11 Journal: Clinical gastroenterology and hepatology : the off [Category] Coronavirus, SARS, 비임상, [키워드] Adverse drug reaction adverse event adverse events Aminotransferase antiviral activity available data Bilirubin breath broad spectrum Cell culture cell cultures clinical development clinical trials Cohort studies cohort study compassionate-use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients disorder double-blind drug drug reaction Drug-induced liver injury elevated EMA European Medicines Agency FDA food healthy volunteer healthy volunteers hepatic hepatic enzyme hepatic enzymes hepatotoxicity hospital human coronavirus increase Infection Intravenous remdesivir investigator investigators Liver injury mouse model Mouse models nucleotide Patient patients hospitalized patients with COVID-19 Placebo placebo recipient placebo recipients placebo-controlled clinical trial proportion raised Randomized recipient Remdesivir reported respiratory safety profile Severe acute respiratory syndrome Severe Acute Respiratory Syndrome-associated Coronavirus 2 severe coronavirus disease severe COVID-19 treated Treatment [DOI] 10.1016/j.cgh.2020.07.050 PMC 바로가기 [Article Type] Multicenter Study
The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19Editorial Published on 2020-10-272022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome administration affecting Anti-inflammatory antioxidant Antithrombotic appear Ascorbate ascorbic acid carried China country COVID-19 Critically ill patient decrease decreased mortality deficiency Efficacy effort elevated Evidence functions greater group IMPROVE include indicated Intervention intravenous investigation low-middle-income monotherapy Mortality observational study optimization overlap oxidative stress Patient patients with COVID-19 patients with pneumonia physiological functions plasma pleiotropic Pneumonia Population prevention protocol Randomized controlled trial Randomized controlled trials RCT RCTs reduce Registered Research risk factor Risk factors role safety profile Sepsis severe coronavirus disease severe respiratory infections severely ill patient severity significantly sustained the disease translation Treatment Trial trials Vitamin Vitamin C with COVID-19 [DOI] 10.3390/nu12113286 PMC 바로가기 [Article Type] Editorial
Impact of Janus Kinase Inhibition on the Treatment of Axial Spondyloarthropathiesarticle Published on 2020-10-212024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] axial spondyloarthritis JAK – STAT signalling pathway preclinical efficacy and tolerability safety profile small molecule inhibitor [DOI] 10.3389/fimmu.2020.591176 PMC 바로가기 [Article Type] article
Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious DiseasesMedical Technology Published on 2020-10-212022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] adaptive adjuvants advance Against antigenic approach caused Clinical studies Coronaviruses COVID-19 develop development DNA DNA plasmid DNA vaccine DNA vaccines DNA-launched nanoparticle vaccines Electroporation elicit emerging infectious diseases (EIDs) hosts humans immune response Immunity in vivo Infectious disease intradermal electroporation intranasal vaccines mammal Other preclinical study Rapid recent replicate response safety profile SARS-CoV-2 significantly more synthetic technology the SARS-CoV-2 virus vaccination Vaccine while [DOI] 10.3389/fmedt.2020.571030 PMC 바로가기 [Article Type] Medical Technology