severe cases – Page 28 – Communicable Diseases Research

Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study

COVID-19에 대한 국가 조기 경보 점수(NEWS2) 평가 및 개선: 다중 병원 연구

Multicenter Study

Published on 2021-01-212022-09-10
Journal: BMC Medicine [Category] MERS, 치료기술,

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

K18-hACE2 쥐, 심각한 COVID-19와 유사한 호흡기 질환 발병

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Asymptomatic Author both groups Brain cerebral cortex chemokines clinical manifestation Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis cytokeratin 18 promoter develop disease disease course disease manifestation dose-dependent DPI etiological agent expressing Extrapulmonary hACE2 hippocampus Human human SARS-CoV-2 humanized immunological disease immunological diseases in both group Infection infectious virus titer inoculated inoculation interstitial pneumonia intestinal tract K18 K18-hACE2 mice lethal disease low dose Lower respiratory tract lung Lungs lymphocyte lymphocyte infiltration Macrophage mice Mild mild to moderate moderate disease nasal turbinates Pathogenesis pathology patients Pneumocytes post inoculation progression proinflammatory Pulmonary pathology rapid inflammatory response receptor replication of SARS-CoV-2 reported respiratory Respiratory disease respiratory tract infection resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe case severe cases severe COVID-19 subset Support survival susceptible TCID Th1 Th1 and proinflammatory cytokines/chemokines the SARS-CoV-2 These data Trachea transgenic mice upper and lower respiratory tract upper and lower respiratory tract infection upregulation Viral Viral RNA shedding virus replication virus titers weight loss while
[DOI] 10.1371/journal.ppat.1009195 PMC 바로가기 [Article Type] Research Article

Disease‐duration based comparison of subsets of immune cells in SARS CoV‐2 infected patients presenting with mild or severe symptoms identifies prognostic markers for severity

경증 또는 중증 증상을 나타내는 SARS CoV-2 감염 환자의 면역 세포 하위 집합의 질병 기간 기반 비교는 중증도에 대한 예후 마커를 식별합니다.

Comparative Study

Published on 2021-01-162022-09-12
Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단,

[키워드] absence adaptive adaptive immune cells Adaptive immunity addition Analysis analyzed Antibody titer association B cells CD8 T cells Cell dendritic cells determined by disease disease severity event expression flow cytometry follicular forms Frequency functional healthy subject help Humoral immunity Hyperactivation identification identify IgG IL‐6 Imbalance Immune cell immune cells Immune profile India indicated infected patient Infection innate immune cell Innate immune cells Lower lymphocyte Lymphocytes management material maturation mDC mDCs memory B cell memory B cells Mild modulation Monocytes Multivariate analysis Neutralizing antibody titer neutralizing antibody titers NK cells observation Older age pandemic Pathogenesis Patient patient cohort patients positive presenting PRNT PRNT50 Prognostic marker Prognostic markers receptor Result SARS CoV‐2 SARS‐CoV‐2 SARS‑CoV2 Severe case severe cases severe disease severe symptom severity Spectrum subset Symptoms T cell T cells T helper cells therapy understanding
[DOI] 10.1002/iid3.402 PMC 바로가기 [Article Type] Comparative Study

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

혈액 전사체의 질병 중증도별 호중구 서명은 COVID-19 환자를 계층화합니다

Research

Published on 2021-01-132022-08-07
Journal: Genome Medicine [Category] 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome analyzed Asymptomatic available data blood cell blood transcriptome Blood transcriptomics capture Cell changes in clinical Clinical parameters Clinical presentations Co-expression analysis Cohort Combination control sample COVID-19 COVID-19 patient data-driven death disease severity dissect Donor driver drug candidate drug candidates targeting Drug repurposing drug target dysregulated explained granulocyte granulocyte sample Granulocytes groups Host host responses identify immune immune system independent Infection Inflammatory diseases Mild mild respiratory mild respiratory tract infection Molecular disease phenotypes molecular phenotype molecular subgroup neutrophil neutrophil activation Neutrophil activation-associated signature Neutrophils other diseases parameters Patient performed phenotype Phenotypes predicted provide report respiratory respiratory distress Respiratory failure respiratory tract infection Result RNA-Seq SARS-CoV-2 pandemic Severe case severe cases severe COVID-19 patient Severe patient Stratification stratified supplementary material syndrome systemic immune response Transcriptome transcriptomes Viral viral infections was used Whole blood whole blood transcriptome
PMC 바로가기 [Article Type] Research

Clinical features and natural history of the first 2073 suspected COVID-19 cases in the Corona São Caetano primary care programme: a prospective cohort study

Infectious Diseases

Published on 2021-01-122022-10-28
Journal: BMJ Open [Category] COVID-19, Fulltext, MERS,

[키워드] Ageusia Anosmia arthralgia assist Brazil Care clinical Clinical data Community consecutive patient Corona cough COVID-19 COVID-19 case COVID-19 cases cycle threshold death Diagnosis Epidemiology Fatality rate fatigue feature Fever finding hospital hospitalisation hospitalised Infection Infectious diseases men Mild Most patient myalgia obesity offered Older age older patients Patient platform population-based cohort positive COVID-19 positive patient presenting primary care prospective cohort study public health respiratory diseases RT-PCR SARS-CoV-2 serology serology testing seropositive severe cases Symptom symptom onset tested transcriptase Virological with COVID-19
[DOI] 10.1136/bmjopen-2020-042745 PMC 바로가기 [Article Type] Infectious Diseases

Chest CT features associated with the clinical characteristics of patients with COVID-19 pneumonia

코로나19 폐렴 환자의 임상적 특징과 관련된 흉부 CT 특징

Research Article

Published on 2021-01-102022-09-01
Journal: Annals of Medicine [Category] 진단,

A rapid screening classifier for diagnosing COVID-19

코로나19 진단을 위한 신속한 선별 분류기

Research Paper

Published on 2021-01-092022-09-12
Journal: International Journal of Biological Sciences [Category] MERS, 진단,

[키워드] Accuracy an area applied approach artificial intelligence AUC caused chest X-ray Classifier classifiers clinical feature Clinical features Clinical finding Clinical findings Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CXR deep learning demonstrated diagnosing Diagnosis diagnostic Diagnostic accuracy diarrhea Efficacy extension feature Fever functional fused global pandemic hypercoagulability Influenza less non-severe cases patients with COVID-19 performed Physicians Pneumonia Radiation rationale Safe sensitivity Severe case severe cases specificity with COVID-19
[DOI] 10.7150/ijbs.53982 PMC 바로가기 [Article Type] Research Paper

Pneumococcal Conjugate Vaccine Protection against Coronavirus-Associated Pneumonia Hospitalization in Children Living with and without HIV

폐렴구균 결합 백신이 HIV 감염 여부에 관계없이 아동의 코로나바이러스 관련 폐렴 입원에 대한 보호 효과

Research Article

Published on 2021-01-082022-10-29
Journal: mBio [Category] COVID-19, MERS, 폐렴구균 감염증,

[키워드] age Analysis Bacterial infection C-reactive protein children clinical manifestation collected conjugate coronavirus Coronavirus infection Coronaviruses CoV CoV infection CoVs described develop double-blind Efficacy elevated Endemic fatality Frequency HIV Hospitalization Hospitalized human coronavirus Human immunodeficiency virus human pathogen incidence individual Infection infections inflammatory markers Lower respiratory tract nasopharyngeal aspirate New coronavirus observation outcomes pandemic participated PCR PCV9 pediatric placebo recipients placebo-controlled clinical trial pneumococcal pneumococcal conjugate vaccine pneumococcal vaccine Pneumonia Prevalence Prevent procalcitonin procalcitonin level protection Randomized randomized trial recipient reported respiratory infections risk SARS-CoV-2 screened secondary bacterial infection severe cases Streptococcus pneumoniae Vaccine with HIV
[DOI] 10.1128/mBio.02347-20 PMC 바로가기 [Article Type] Research Article

2019 novel coronavirus disease with secondary ischemic stroke: two case reports

Case Report

Published on 2021-01-052022-10-27
Journal: BMC Neurology [Category] COVID-19,

2019 novel coronavirus disease with secondary ischemic stroke: two case reports

Case Report

Published on 2021-01-052022-10-27
Journal: BMC Neurology [Category] Coronavirus, COVID-19,