Repurposing prolactin as a promising immunomodulator for the treatment of COVID-19: Are common Antiemetics the wonder drug to fight coronavirus?COVID-19 치료를 위한 유망한 면역 조절제로 프로락틴 용도 변경: 일반적인 항구토제는 코로나바이러스와 싸우는 놀라운 약물입니까?Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료제, [키워드] adaptive Adaptive immunity antagonist Antiemetics Autoimmune diseases Blood clinical trial conditions conducted coronavirus Course COVID COVID-19 Critical death Domperidone Dopamine drug elevated evade explained hyperprolactinemia hypoprolactinemia Hypothesis immune function immune modulation immune-stimulatory Immunity immunological immunomodulator Immunotherapy in some induce Infection lactogenic lactogenic hormone lead limit long term Metoclopramide Mild nausea nausea and vomiting observation opportunistic infection outcome pathological condition Patient physiological PRL Prolactin Prophylactic reported repurposing SARS-CoV-2 serum Seven survival the patient therapeutic Treatment vomiting women [DOI] 10.1016/j.mehy.2020.110208 PMC 바로가기 [Article Type] Article
Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patientsArticle Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] adaptive Adaptive immunity age analyzed B cell CD3 CD4 clinically collected comparable COVID-19 COVID-19 patient demonstrated disease onset healthy controls healthy subject healthy subjects hospital Immune cell immune cells Infectious diseases Laboratory laboratory data lymphocyte subpopulation Microbiology monitoring NK cell non-severe patient Patient patients persistent positive Recovered COVID-19 patients recruited reduced SARS-CoV-2 significantly higher significantly increased T cell T cells the SARS-CoV-2 transferred university Wuhan [DOI] 10.1038/s41598-020-73955-8 PMC 바로가기 [Article Type] Article
Landscape of coordinated immune responses to H1N1 challenge in humansResearch Article Published on 2020-10-122023-06-14 Journal: The Journal of Clinical Investigation [Category] Fulltext, 신종인플루엔자, [키워드] Adaptive immunity immunology Infectious disease Influenza Innate immunity [DOI] 10.1172/JCI137265 PMC 바로가기 [Article Type] Research Article
Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemicResearch Highlight Published on 2020-10-062022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Adaptive immunity COVID-19 pandemic domain effective Infectious diseases Vaccines [DOI] 10.1038/s41392-020-00317-1 PMC 바로가기 [Article Type] Research Highlight
A simple protein-based surrogate neutralization assay for SARS-CoV-2Research Article Published on 2020-10-022022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] ACE2 acute respiratory syndrome Adaptive immunity angiotensin-converting enzyme 2 antibody Antigen assays characterized Clinical outcome Cohort Convalescent patients Convalescent plasma therapy coronavirus detect ELISA humoral immune response immune correlate immunoglobulins Infection Infectious disease Interaction live SARS-CoV-2 MOST neutralization Neutralization assay neutralizing antibody Patient performed plaque reduction neutralization platform PRNT pseudotyped public health RBD receptor Receptor binding domain Safe SARS-CoV-2 SARS-COV-2 infection serum and plasma Spike protein Support the patient the RBD the SARS-CoV-2 treatment approaches Vaccination strategies virus while [DOI] 10.1172/jci.insight.142362 PMC 바로가기 [Article Type] Research Article
Kinetics of viral load and antibody response in relation to COVID-19 severityClinical Trial Published on 2020-10-012023-07-06 Journal: The Journal of Clinical Investigation [Category] SARS, [키워드] Adaptive immunity Infectious disease Molecular biology Molecular diagnosis Virology [DOI] 10.1172/JCI138759 PMC 바로가기 [Article Type] Clinical Trial
Naturally activated adaptive immunity in COVID‐19 patientsCOVID-19 환자의 자연 활성화된 적응 면역Original Article Published on 2020-09-252022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] 바이오마커, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity age B cell Blood blood sample Blood samples Care caused CD25 CD4 CD8 T cell CD8 T cells Cell changes in collected coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 demonstrated Evidence expression follicular functional germinal centre groups Health healthy donor immune cell population immune response Immunity immunological characteristics induce information lymphocyte Lymphocytes marker Medical care Most patients Naturally parameter Patient PD‐1 Phenotypes receiving remained respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus Spread T and B cells T cell T cells These data was increased [DOI] 10.1111/jcmm.15771 PMC 바로가기 [Article Type] Original Article
Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunityResearch Article Published on 2020-09-172022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adaptive immunity antibody Antibody detection Antibody Response binding antibody circulating antibody collected coronavirus correlation COVID-19 COVID-19 immunity detection ELISA exhibited Generation Health healthy IgG antibody immune response Immunity immunology implication individual moderate N-protein neutralize Neutralizing antibodies neutralizing capacity nucleocapsid pandemic patients positive Protein Quantitative Receptor binding domain reverse transcription S-RBD SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike sera Seroconversion serological serology assay serology testing serum sample Spike protein the SARS-CoV-2 Viral protein virus infection [DOI] 10.1172/jci.insight.142386 PMC 바로가기 [Article Type] Research Article
Selenium and selenoproteins in viral infection with potential relevance to COVID-19COVID-19와 잠재적 관련성이 있는 바이러스 감염의 셀레늄 및 셀레노단백질Review Published on 2020-09-102022-09-10 Journal: Redox Biology [Category] SARS, 치료제, [키워드] adaptive Adaptive immunity association benefit Chinese patient Chinese patients contribute Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19-associated inflammation Culture cure rate cytokine Cytokine activation doses Ebselen ENhance ER stress evade example explain expression functions Health Host host immunity host response hosts IL-6 immune response Immunity in viral incidence increased expression Infection inhibit SARS-CoV-2 inhibitor involved linear maturation mechanism mediator metabolite morbidity morbidity and mortality Pathogenesis pathogenic pharmacological play roles positive potential benefit potential benefits Prevent Proteases PROTECT Protective provide randomised rationale Recognition Redox-active selenium species reduced reducing required RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 protease Selenium selenoprotein Selenoproteins serum sample serum samples severity significantly significantly higher Trace element Viral viral infections viral pathogenesis virus viruses with COVID-19 [DOI] 10.1016/j.redox.2020.101715 PMC 바로가기 [Article Type] Review
Storm of soluble immune checkpoints associated with disease severity of COVID-19Letter Published on 2020-09-072022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, [키워드] Adaptive immunity COVID-19 disease severity immune Infectious diseases storm [DOI] 10.1038/s41392-020-00308-2 PMC 바로가기 [Article Type] Letter